This is some info i found last night while looking around, it looks interesting.
"ATD (1,4,6-Androstatriene-3,17-dione)
The majority of testosterone (approximately 98%) that is transported in the blood is bound to protein carriers, such as sex hormone binding globulin (SHBG) and albumin. Therefore, only a small amount of testosterone (approximately only 2%) is actually free, or bioactive. When testosterone is bound, it cannot exert its anabolic activity at the receptor site. In order for testosterone to be useful, it must be unbound; this is referred to as “Free-Testosterone”. Therefore, the desired goal for optimal muscle building and male performance is to increase Free-Testosterone. Free-Testosterone can also be converted to estrogen via the aromatase enzyme. Therefore, inhibiting the aromatase enzyme’s activity will result in increasing the amount of testosterone, in particular, the free, bioactive testosterone.
ATD or 1,4,6-Androstatriene-3,17-dione is a potent irreversible aromatase inhibitor. It inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral tissue. By reducing the production of estrogen, circulating estrogen levels drop, which in turn indirectly increases testosterone levels.
ATD provides benefits far beyond simply controlling estrogen in your body. Through its control over the androgen negative feedback loop testosterone production is restarted much faster. And the faster you recover your natural testosterone production the easier it is to keep muscular gains.
In addition to ATD’s benefits for post cycle therapy studies have shown that employing ATD during AAS use maintains significant HPTA function. This means reduced testicular atrophy and faster post-cycle recovery. This is something that you simply can’t get from estrogen control alone.
ATD can also be used by the natural athlete to increase testosterone production. In studies increases of up to 400% in testosterone have been seen. This is equivalent to injecting 400-600mg per week of testosterone enanthate or cypionate. This means continued growth for the natural athlete without the problems and side effects usually associated with injecting testosterone.
Dosing:
For increased Testosterone levels: Take 1ml each evening with dinner (1ml is 25mg). Do not exceed the recommended dose.
ATD may be taken in conjunction with Ostarine (Ostarine is best taken at a dose of 1ml per day, half an hour before a workout) which will further boost testosterone levels and aid in muscle development.
For Post Cycle Therapy: Take 1ml (1ml is 25mg) daily during the last two weeks of a cycle and then for an additional three weeks following the end of the cycle then 1ml every other day for one week."
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