DAPOXETINE

[johnjuanb1]

Dapoxetine for premature ejaculation.

Journal
Drug Ther Bull. 2014 Mar;52(3):30-3. doi: 10.1136/dtb.2014.3.0240.

ABSTRACT
Premature ejaculation, also referred to as rapid or early ejaculation, is a poorly understood disorder with no single, widely-recognised, evidence-based definition. Studies based on patient self-reporting indicate that premature ejaculation is a common complaint with estimated prevalence ranging from 4%-39% of men in the general community.(1) However, a lack of an accurate validated definition has made comparison of the results of such studies difficult.(2) In addition, perception of normal ejaculatory latency varies by country and differs when assessed by the patient or their partner.(3) ▾Dapoxetine (Priligy-A. Menarini Farmaceutica Internazionale SRL), a short-acting selective serotonin reuptake inhibitor (SSRI) is the first drug to be licensed in the UK for on-demand management of diagnosed premature ejaculation.(4) In this article we review the evidence for dapoxetine and discuss some of the challenges associated with its introduction.

 

[johnjuanb1]

Dapoxetine: an evidence-based review of its effectiveness in treatment of premature ejaculation.

AuthorsMcCarty E, et al. Show all Journal
Core Evid. 2012;7:1-14. doi: 10.2147/CE.S13841. Epub 2012 Jan 19.

ABSTRACT
Premature ejaculation (PE) is a major issue in male sexual health. The global prevalence of PE is estimated to be between 20% and 40%, making it the most common sexual dysfunction in men. PE causes distress and reduced quality of life for patients and has a negative impact on interpersonal relationships. Historically, it has been treated with cognitive therapy, behavioral methods, and off-label use of selective serotonin reuptake inhibitors usually used to treat depression and other psychological disorders. Dapoxetine is a selective serotonin reuptake inhibitor specifically designed to treat PE. This paper reviews the current evidence for use of dapoxetine in the treatment of PE in adult men. There is substantial evidence that dapoxetine 30 mg or 60 mg taken "on-demand" results in a significant increase in intravaginal ejaculatory latency time when compared with placebo. Patient-reported outcomes are clearly improved relative to placebo following dapoxetine therapy, indicating greater control over ejaculation, more satisfaction with intercourse, less ejaculation-related distress, and, importantly, significantly reduced interpersonal difficulty. These data were supported by consistent reports of improvement in Clinical Global Impression of change in PE following treatment with dapoxetine. Further studies are needed to evaluate long-term efficacy and health economics. The unique pharmacology of dapoxetine makes it ideal for on-demand dosing, and the clinical evidence shows dapoxetine to be an efficacious and tolerable treatment for lifelong and acquired PE.

 

[SAGE74]

Is there a drug that makes u nut faster! It takes me forever to nut, it sucks!

 

[johnjuanb1]

Is there a drug that makes u nut faster! It takes me forever to nut, it sucks!

Hahahaha nice!!! Not sure on that. Maybe the cure is a tighter vagina?

 

[SAGE74]

Hahahaha nice!!! Not sure on that. Maybe the cure is a tighter vagina?

U might be right, or a bigger dick.

 

[johnjuanb1]

Perhaps this is the problem???

 

[johnjuanb1]

It's been so long since I've had a girlfriend I will definitely be trying this one out when I get one. There's nothing more embarrassing than being a one minute man. And you know she'll tell all her girlfriends.

 

[Elvia1023]

I told my mate about this and he wants it bad. He always says when he gets a new girl it is over very quick.

I take a small dose of citalopram for anxiety. It's probably not even needed now but I like it. Plus it causes no bad side effects and I can't be bothered with the withdrawal. That's an SSRI like Dapoxetine and let me tell you I literally have full control. I could go on for 3 hours straight if I wanted to. The big difference though between the two is dapoxetine is absorbed and eliminated rapidly in the body. Therefore it's not suitable for anxiety etc but used solely for premature ejaculation. I imagine for some PE could ruin their confidence and sex life so this really is a miracle drug and could change lives. Not even exaggerating there as we all know how important sex is and if you feel insecure about sex it must have a massive effect on confidence, dating and general happiness.

 

[johnjuanb1]

It's definitely better to look like a man in control when having sex, then like a 13 year boy getting his first sexual experience.

 

[johnjuanb1]

This study show it's safe to stack dapoxetine with tadalafil or sildenafil.

Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors.

AuthorsDresser MJ, et al. Show all Journal
Int J Impot Res. 2006 Jan-Feb;18(1):104-10.

Affiliation
Abstract
Potential pharmacokinetic interactions between dapoxetine, a serotonin transporter inhibitor developed for the treatment of premature ejaculation (PE), and the phosphodiesterase-5 inhibitors tadalafil and sildenafil, agents used in the treatment of erectile dysfunction (ED), were investigated in an open-label, randomized, crossover study (n=24 men) comparing dapoxetine 60 mg, dapoxetine 60 mg+tadalafil 20 mg, and dapoxetine 60 mg+sildenafil 100 mg. Plasma concentrations of dapoxetine, tadalafil, and sildenafil were determined by liquid chromatography-tandem mass spectrometry. Tadalafil did not affect the pharmacokinetics of dapoxetine, whereas sildenafil increased the dapoxetine AUCinf by 22%; these effects were deemed not clinically important. Dapoxetine did not appear to affect the pharmacokinetics of tadalafil or sildenafil. Most adverse events were mild in nature. Thus, dapoxetine has no clinically important pharmacokinetic interactions with tadalafil or sildenafil, and the combinations are well tolerated.

PMID 16307008 [PubMed - indexed for MEDLINE]

 

[Snuka]

Who carries Dapox now? I have used it from a couple of sponsors a couple of years ago and forgot who they were. Both were legit and definitely worked real well.

 

[Elvia1023]

I would definitely go with tadalafil over sildenafil but that's just me

This study show it's safe to stack dapoxetine with tadalafil or sildenafil.

Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors.

AuthorsDresser MJ, et al. Show all Journal
Int J Impot Res. 2006 Jan-Feb;18(1):104-10.

Affiliation
Abstract
Potential pharmacokinetic interactions between dapoxetine, a serotonin transporter inhibitor developed for the treatment of premature ejaculation (PE), and the phosphodiesterase-5 inhibitors tadalafil and sildenafil, agents used in the treatment of erectile dysfunction (ED), were investigated in an open-label, randomized, crossover study (n=24 men) comparing dapoxetine 60 mg, dapoxetine 60 mg+tadalafil 20 mg, and dapoxetine 60 mg+sildenafil 100 mg. Plasma concentrations of dapoxetine, tadalafil, and sildenafil were determined by liquid chromatography-tandem mass spectrometry. Tadalafil did not affect the pharmacokinetics of dapoxetine, whereas sildenafil increased the dapoxetine AUCinf by 22%; these effects were deemed not clinically important. Dapoxetine did not appear to affect the pharmacokinetics of tadalafil or sildenafil. Most adverse events were mild in nature. Thus, dapoxetine has no clinically important pharmacokinetic interactions with tadalafil or sildenafil, and the combinations are well tolerated.

PMID 16307008 [PubMed - indexed for MEDLINE]

 

[johnjuanb1]

Who carries Dapox now? I have used it from a couple of sponsors a couple of years ago and forgot who they were. Both were legit and definitely worked real well.

Clock on the banner in my signature. Superior carries it.

 

[johnjuanb1]

Dapoxetine lengthened normal ejaculation time by about 300% at a dose of 30mg taken one hour before intercourse, and about 400% at a dose of 60mg.

 

[johnjuanb1]

A benefit-risk assessment of dapoxetine in the treatment of premature ejaculation.

AuthorsHutchinson K, et al. Show all Journal
Drug Saf. 2012 May 1;35(5):359-72. doi: 10.2165/11598150-000000000-00000.

Affiliation
Abstract
Premature ejaculation (PE) is considered to be the most common sexual problem affecting men, despite the likelihood that it is under-diagnosed. It is a complex condition with many physical and psychological components, making management complicated. It is important to develop treatments for PE as it adversely affects quality of life for individuals and partners. Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that has been developed principally for the treatment of PE. It is considered more suitable for the treatment of PE than other SSRIs as it can be used as an 'on demand' treatment to be taken a few hours before an expected sexual encounter, reducing the possibility of adverse effects. Dapoxetine may represent a breakthrough in the treatment of PE as it is the first drug to be licensed for this indication. This review attempts to present a balanced benefit-risk assessment of dapoxetine by examining the evidence from phase III clinical trials, focusing on its efficacy in prolonging intravaginal ejaculatory latency time (IELT), patient sexual satisfaction and safety in patients with PE. The benefits and risks of other therapies that are used to treat PE off-licence are also reviewed. There has only been one study to date that directly compares dapoxetine to another therapy, paroxetine, for this indication. It was found that dapoxetine is most effective at a dose of 60 mg in increasing IELT compared with placebo. All studies have also found that dapoxetine is well tolerated as an 'on-demand' therapy and with continual dosing; however, there are little data regarding possible long-term adverse effects. Findings of the dapoxetine development programme demonstrated that dapoxetine is associated with vasovagal-mediated (neurocardiogenic) syncope. No other associated significant cardiovascular adverse events were identified. Further research is needed to directly compare dapoxetine with other therapies and to investigate the outcomes of dapoxetine used in conjunction with behavioural therapies, and other non-pharmaceutical therapies.

 

[Knight9]

Have you used it JJ? Why don't the reps use it and report back? Just a thought. And yes I have used it.

Not attacking you...just the copy and paste jobs get old and the reps should have first hand experience with the stuff. I was striving to make that happen at one point.

Sent from my SM-N900V using Tapatalk

 

[Elvia1023]

Have you used it JJ? Why don't the reps use it and report back? Just a thought. And yes I have used it.

Not attacking you...just the copy and paste jobs get old and the reps should have first hand experience with the stuff. I was striving to make that happen at one point.

Sent from my SM-N900V using Tapatalk

Anything I recommend I try to use first (common sense). Too many recommend stuff with a concrete opinion but have never used it. JJ is just providing studies so guys can learn. Many readers don't want to research themselves and it keeps the threads bumped up. So for anyone interested when they click on the thread they have a lot of info so I think it is only a good thing.

I can always help guys out with dosing stuff (I haven't used) due to research but they could themselves if they spent 30 mins researching a subject. For something like this I simply don't need it so would never use it. Plus I use something very similar so this would be OTT. Being blunt sometimes it can hard for me to (you know what) so adding this would not make sense. My best mate really does want this though so I may get it for him so he can try it out. So sure reps should use what they recommend but we can't use everything we sell. All that combined plus the fact JJ has not got any action for a long time!

 

[Pbfanatic321]

I've used it from a sponsor on here and yes it works. Take it about an hour to an hour and a half before you have sex and you don't bust. Only problem is, which is weird, is my dick gets soft even though I take cialis as well. I think the dapoxetine makes you lose some feeling and that's why my dick gets soft. I don't know, its weird.

 

[raw33man]

for me, no matter what, I cum fast the first round... the second round I can actually control myself and decide when I want to cum ! Ain't that cool ?

So I take prami in order to get my wood up faster after I bust the first time

 

[johnjuanb1]

I've used it from a sponsor on here and yes it works. Take it about an hour to an hour and a half before you have sex and you don't bust. Only problem is, which is weird, is my dick gets soft even though I take cialis as well. I think the dapoxetine makes you lose some feeling and that's why my dick gets soft. I don't know, its weird.

If it starts going soft it's her fault damn it! Bahahahaha