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LGD-4033

johnjuanb1

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The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men.

AuthorsBasaria S, et al. Show all Journal
J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):87-95. doi: 10.1093/gerona/gls078. Epub 2012 Mar 28.

ABSTRACT

BACKGROUND:
Concerns about potential adverse effects of testosterone on prostate have motivated the development of selective androgen receptor modulators that display tissue-selective activation of androgenic signaling. LGD-4033, a novel nonsteroidal, oral selective androgen receptor modulator, binds androgen receptor with high affinity and selectivity. Objectives. To evaluate the safety, tolerability, pharmacokinetics, and effects of ascending doses of LGD-4033 administered daily for 21 days on lean body mass, muscle strength, stair-climbing power, and sex hormones.

METHODS: In this placebo-controlled study, 76 healthy men (21-50 years) were randomized to placebo or 0.1, 0.3, or 1.0 mg LGD-4033 daily for 21 days. Blood counts, chemistries, lipids, prostate-specific antigen, electrocardiogram, hormones, lean and fat mass, and muscle strength were measured during and for 5 weeks after intervention.

RESULTS: LGD-4033 was well tolerated. There were no drug-related serious adverse events. Frequency of adverse events was similar between active and placebo groups. Hemoglobin, prostate-specific antigen, aspartate aminotransferase, alanine aminotransferase, or QT intervals did not change significantly at any dose. LGD-4033 had a long elimination half-life and dose-proportional accumulation upon multiple dosing. LGD-4033 administration was associated with dose-dependent suppression of total testosterone, sex hormone-binding globulin, high density lipoprotein cholesterol, and triglyceride levels. follicle-stimulating hormone and free testosterone showed significant suppression at 1.0-mg dose only. Lean body mass increased dose dependently, but fat mass did not change significantly. Hormone levels and lipids returned to baseline after treatment discontinuation.

CONCLUSIONS:LGD-4033 was safe, had favorable pharmacokinetic profile, and increased lean body mass even during this short period without change in prostate-specific antigen. Longer randomized trials should evaluate its efficacy in improving physical function and health outcomes in select populations.
 
New SARM JJ?
Im a bit leary of these will have to wait to see results from real world application.
 
Anybody carry this yet??


Sent from my iPP using Tapatrash
 
Nice, I'm waiting for one of the PH companies to make this. They're already making MK-2866 as a PH type supplement over here (with flashy names and packaging...but it's Ostarine, plain and simple) and I'm stocking up. This one should be even better...
 
Anybody carry this yet??


Sent from my iPP using Tapatrash

SuperiorPeptide carries it. We have a buy two, get one free deal. Look below at my signature for the buy two, get one free discount code and click on my banner.
 
Nice, I'm waiting for one of the PH companies to make this. They're already making MK-2866 as a PH type supplement over here (with flashy names and packaging...but it's Ostarine, plain and simple) and I'm stocking up. This one should be even better...

This is the newest on the market and gaining popularity fast.
 
do we need full fledge PCT after?
 
do we need full fledge PCT after?

With LGD it is a good idea, as it is suppressive. It's not as suppressive as AAS in general, but you will still need some help with recovery if you want to recover as quickly as possible.
 

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    Blue-Eyed Devil

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