HGH half life and negative feedback loop

[FranJ]

Greetings!

Like many hormones wich are triggered by the HPTA growth hormone has a negative feedback loop, at high levels of the hormone it will blunt the natty release of it.

What do we know of HGH about this? Usually people inject it first thing in the morning to avoid this negative feedback loop, but do we really know the true half life of HGH? I've read from 4h to 12h...

Does that mean that injecting in the afternoon would blunt our night HGH pulse? it's dose dependent?

I'd like to clarify this point since internet is full of 'broscience' in this topic.

 

[Knight9]

Hgh takes 4 hrs to run its course/be metabolized.

 

[FranJ]

Hgh takes 4 hrs to run its course/be metabolized.

Hmmm, so that means that after 4 hours we will produce rest of pulses?

For instance, if you pin 4iu at 8.00PM you should get night pulse.

 

[Knight9]

Hmmm, so that means that after 4 hours we will produce rest of pulses?

For instance, if you pin 4iu at 8.00PM you should get night pulse.

I wouldn't pin it at 8 pm unless that happened to be pre workout.

I'm not quite sure what you're so concerned about because endogenous GH production is near nil compared to exogenous. Inject your GH pre or post workout, before bed, or upon waking.

 

[Press]

Hmmm, so that means that after 4 hours we will produce rest of pulses?

For instance, if you pin 4iu at 8.00PM you should get night pulse.

i could be wrong but i think it would be very minimal. you would be better off taking ipamorelin/cjc no dac for a better pulse.

 

[FranJ]

I wouldn't pin it at 8 pm unless that happened to be pre workout.

I'm not quite sure what you're so concerned about because endogenous GH production is near nil compared to exogenous. Inject your GH pre or post workout, before bed, or upon waking.

My main concern is to make the most of natural and synthetic GH.

I read somewhere that the negative feedback loop lasts 24h after some time using exogenous GH, if you are using some kind of chinese crap GH you are probably blunting your natural pulses and injecting a really small amount that doesn't make any difference.

Would be great to know exactly how does this feedback loop affects HPTA in regards to GH.

 

[Knight9]

My main concern is to make the most of natural and synthetic GH.

I read somewhere that the negative feedback loop lasts 24h after some time using exogenous GH, if you are using some kind of chinese crap GH you are probably blunting your natural pulses and injecting a really small amount that doesn't make any difference.

Would be great to know exactly how does this feedback loop affects HPTA in regards to GH.

If you wanted to make the most out of natural and synthetic, you'd probably use peptides when appropriate and pharma gh other times. Worrying about 24hr negative feedback is not necessary.

 

[FranJ]

By the way, even at 2iu ED your IGF levels get elevated, so that probably means that our natty production is totally blunt, I may be wrong.

 

[FranJ]

If you wanted to make the most out of natural and synthetic, you'd probably use peptides when appropriate and pharma gh other times. Worrying about 24hr negative feedback is not necessary.

Alright mate, thanks for your tips !