GHRP and CJC 1295 no dac Versus GHRP and BPC 157

[boxer cam]

So it seems GHRP and CJC are the go to combo. But what does the body utilize better, the extra bit of GH release that CJC adds or is the enhanced GH receptor expression from BPC 157 of more benift. Obviously if cost wasn't a factor, then all 3 would be best bet to cover all base's.

100 mcg of BPC 157 and 100 mcg of GHRP both 3 times a day, with the BPC 157 taken about 45 minutes before the GHRP is more cost affective than the 100/100 GHRP/CJC 3 times a day. But what has more affect.

Has anyone tried this type of protocol or got a option to share? Thanks.

 

[johnjuanb1]

I would stick with stacking a GHRP with a GHRH unless someone does serum HGH blood blood to prove a GHRP stacked with BPC157 tests as high.

 

[boxer cam]

I would stick with stacking a GHRP with a GHRH unless someone does serum HGH blood blood to prove a GHRP stacked with BPC157 tests as high.

Indeed GH serum blood test would be great to see if BPC 157 has any affect on the size of the pulse produced by GHRP, but in this combo I'm questioning more the use of BPC 157 to use the same pulse more effectively. Is there a blood test for the receptors?

Thanks for replying, I read a lot of your post and you have amazing knowledge.

 

[boxer cam]

So looking at it another way. Take the CJC versus BPC out of the equation and look at the benefits of dosing BPC 157 with both GHRP and CJC.

If BPC 157 is capable of enhanced receptor expression, then surely we should be seeing protocols of the following.

100 mcg GHRP/100 mcg CJC no dac/100 mcg BPC157 three times a day, with the BPC injected about 45 minutes before the other two.

It would be interesting to find out if BPC 157 is affecting other receptors, other than the GH receptor. If it has affect on the GHRHR or GHSR, then the benefits could be on the release as well.

 

[DORIAN*]

So looking at it another way. Take the CJC versus BPC out of the equation and look at the benefits of dosing BPC 157 with both GHRP and CJC.

If BPC 157 is capable of enhanced receptor expression, then surely we should be seeing protocols of the following.

100 mcg GHRP/100 mcg CJC no dac/100 mcg BPC157 three times a day, with the BPC injected about 45 minutes before the other two.

It would be interesting to find out if BPC 157 is affecting other receptors, other than the GH receptor. If it has affect on the GHRHR or GHSR, then the benefits could be on the release as well.

What makes you think BPC 157 would have any effect on GH receptors?

 

[johnjuanb1]

What makes you think BPC 157 would have any effect on GH receptors?

They proved it affects HGH receptors inside a rat tendon, or something like that.

Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts.
Chang CH, et al. Molecules. 2014.
Show full citation
Abstract
BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat. From the result of cDNA microarray analysis, growth hormone receptor was revealed as one of the most abundantly up-regulated genes in tendon fibroblasts by BPC 157. BPC 157 dose- and time-dependently increased the expression of growth hormone receptor in tendon fibroblasts at both the mRNA and protein levels as measured by RT/real-time PCR and Western blot, respectively. The addition of growth hormone to BPC 157-treated tendon fibroblasts dose- and time-dependently increased the cell proliferation as determined by MTT assay and PCNA expression by RT/real-time PCR. Janus kinase 2, the downstream signal pathway of growth hormone receptor, was activated time-dependently by stimulating the BPC 157-treated tendon fibroblasts with growth hormone. In conclusion, the BPC 157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon.

 

[DORIAN*]

I think if a study conclusively states something then it is likley the truth but at the same time it is only 1 study. This study sounds promising but at the same time it is only showing it in tendon fibroblasts isolated from the Achilles tendon,,, plus in rats. Hopefully it does increase the effectiveness of hgh but it still may not do that in muscle or other areas. Although if it is doing it in the tendon chances are it is doing it elsewhere. But that doesn't mean it would increase the effectiveness of GHRP-2 as an example. I think more testing definitely needs to be done before we can state conclusively it will make hgh and peptides more effective.

They proved it affects HGH receptors inside a rat tendon, or something like that.

Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts.
Chang CH, et al. Molecules. 2014.
Show full citation
Abstract
BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat. From the result of cDNA microarray analysis, growth hormone receptor was revealed as one of the most abundantly up-regulated genes in tendon fibroblasts by BPC 157. BPC 157 dose- and time-dependently increased the expression of growth hormone receptor in tendon fibroblasts at both the mRNA and protein levels as measured by RT/real-time PCR and Western blot, respectively. The addition of growth hormone to BPC 157-treated tendon fibroblasts dose- and time-dependently increased the cell proliferation as determined by MTT assay and PCNA expression by RT/real-time PCR. Janus kinase 2, the downstream signal pathway of growth hormone receptor, was activated time-dependently by stimulating the BPC 157-treated tendon fibroblasts with growth hormone. In conclusion, the BPC 157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon.

 

[boxer cam]

I think if a study conclusively states something then it is likley the truth but at the same time it is only 1 study. This study sounds promising but at the same time it is only showing it in tendon fibroblasts isolated from the Achilles tendon,,, plus in rats. Hopefully it does increase the effectiveness of hgh but it still may not do that in muscle or other areas. Although if it is doing it in the tendon chances are it is doing it elsewhere. But that doesn't mean it would increase the effectiveness of GHRP-2 as an example. I think more testing definitely needs to be done before we can state conclusively it will make hgh and peptides more effective.

Therein lies the problem with BPC 157. We are yet to fully understand it's mechanisms. We have the one report that is specific to one area. Human trials for its intended use for the stomach, that show positives to other organs like the liver. Then we have many people backing it's use for joint healing.

It does leave the door open for the possibility of it's use for more than just healing. Testing and time will tell us the answer like always.

 

[johnjuanb1]

Therein lies the problem with BPC 157. We are yet to fully understand it's mechanisms. We have the one report that is specific to one area. Human trials for its intended use for the stomach, that show positives to other organs like the liver. Then we have many people backing it's use for joint healing.

It does leave the door open for the possibility of it's use for more than just healing. Testing and time will tell us the answer like always.

It definitely has great possibilities. It would make sense that anything that speeds of healing of muscle tissue would build muscle faster. Weight lifting tears muscle tissue. BPC157 speeds up the repair of the tissue. New tissue gets added. The premise is as basic as weight lifting itself.

 

[boxer cam]

At what level do we get saturation of the growth hormone receptors. We have growth hormone receptors all over our body, that use growth hormone for all different uses. But we are mainly interested in what it does for muscle, correct?

So that would mean that even know we can use high levels in our body, not all would be used for the purpose of muscle gain. If we were to increase GH receptor expression locally in the muscles that we are going to workout. Then would that not focus growth hormone to our goal of muscle gain. At the moment it is seems that BPC 157 is the peptide most suited for the job.

Obviously further research is needed and also the confirmation of how much of the effects of BPC 157 are local or systematic. Even know the affects of BPC 157 seem to build up over time, if the positive effects on receptor expression happen immediately after injection. Then there would still be benefit to timed injections.

Surely the abnormal growth seen by 10-20iu a day HGH injections show us that at high levels it attaches to unwanted receptors, as this abnormal growth is not seen at lower levels.

Which bring me back to my original idea. That adding BPC 157 to GHRP to give growth hormone more receptor activity in the muscles, could be as affective as elevating higher levels of GH. Still all three (GHRP, BPC 157 and CJC) should be better again.