New 2016 Tadaifil Study- reduces VAT(visceral fat) by restoring insulin sensitivity

[johnjuanb1]

Tadalafil reduces visceral adipose tissue accumulation by promoting preadipocytes differentiation towards a metabolically healthy phenotype: Studies in rabbits.
Maneschi E, et al. Mol Cell Endocrinol. 2016.

Abstract

Development of metabolically healthy adipocytes within dysfunctional adipose tissue may represent an attractive way to counteract metabolic syndrome (MetS). In an experimental animal model of high fat diet (HFD)-induced MetS, in vivo,long- and short-term tadalafil treatments were able to reduce visceral adipose tissue (VAT) accumulation and hypertriglyceridemia, and to induce the expression in VAT of the brown fat-specific marker, uncoupling protein 1 (UCP1). VAT preadipocytes (PAD), isolated from the tadalafil-treated HFD rabbits, showed: i) a multilocular morphology; ii) an increased expression of brown fat-specific genes (such as UCP1 and CIDEA); iii) improved mitochondrial structure and dynamic and reduced superoxide production; iv) improved insulin sensitivity. Similar effects were obtained after in vitro tadalafil treatment in HFD rPAD. In conclusion, tadalafil counteracted HFD-associated VAT alterations, by restoring insulin-sensitivity and prompting preadipocytes differentiation towards a metabolically healthy phenotype.

Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

 

[Capin]

I really could use summ cialis!

 

[RamboStallone]

Tadalafil has soo many benefits. It should be part of every males daily arsenal.

Thanks for sharing JJ.

 

[AmM]

Tadalafil reduces visceral adipose tissue accumulation by promoting preadipocytes differentiation towards a metabolically healthy phenotype: Studies in rabbits.
Maneschi E, et al. Mol Cell Endocrinol. 2016.

Abstract

Development of metabolically healthy adipocytes within dysfunctional adipose tissue may represent an attractive way to counteract metabolic syndrome (MetS). In an experimental animal model of high fat diet (HFD)-induced MetS, in vivo,long- and short-term tadalafil treatments were able to reduce visceral adipose tissue (VAT) accumulation and hypertriglyceridemia, and to induce the expression in VAT of the brown fat-specific marker, uncoupling protein 1 (UCP1). VAT preadipocytes (PAD), isolated from the tadalafil-treated HFD rabbits, showed: i) a multilocular morphology; ii) an increased expression of brown fat-specific genes (such as UCP1 and CIDEA); iii) improved mitochondrial structure and dynamic and reduced superoxide production; iv) improved insulin sensitivity. Similar effects were obtained after in vitro tadalafil treatment in HFD rPAD. In conclusion, tadalafil counteracted HFD-associated VAT alterations, by restoring insulin-sensitivity and prompting preadipocytes differentiation towards a metabolically healthy phenotype.

Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Do you know what dosage was used for this study?

 

[FrancisK]

I really could use summ cialis!

Is that your buns Capin??

 

[Capin]

No no bunnies I'm a cat person.
I do use cialis 10mg eod on non training days
Viagra 50mg b4 my workouts
Cialis for phat loss hhmmmm gonna have to see some real world human results.
Kause I'm oneathose mofos that gotta CIT b4 I believe it

 

[johnjuanb1]

Do you know what dosage was used for this study?

You can buy the full text here.
Tadalafil reduces visceral adipose tissue accumulation by promoting preadipocytes differentiation towards a metabolically healthy phenotype: Studies in rabbits

The abstract doesn't mention the rabbit dosage.

 

[willswheels]

JJ...

I have the article in a PDF... It's 21 pages and too large to attach. PM me if you want it.

Will

 

[AmM]

You can buy the full text here.
Tadalafil reduces visceral adipose tissue accumulation by promoting preadipocytes differentiation towards a metabolically healthy phenotype: Studies in rabbits

The abstract doesn't mention the rabbit dosage.

Thanks man!

 

[Massive G]

18 -24 month study

Eur Urol. 2004 Mar;45(3):339-44; discussion 344-5.
Long-term safety and tolerability of tadalafil in the treatment of erectile dysfunction.
Montorsi F1, Verheyden B, Meuleman E, Jünemann KP, Moncada I, Valiquette L, Casabé A, Pacheco C, Denne J, Knight J, Segal S, Watkins VS.
Author information
Abstract
OBJECTIVE:
To assess the long-term safety and tolerability of tadalafil for patients with erectile dysfunction (ED).

PATIENTS AND METHODS:
This was a multicentre, open-label, 24-month extension trial involving 1173 men with ED. The mean age was 57 (range 23-83) years and 74.8% of patients were taking concomitant medications for comorbid conditions, including diabetes mellitus in 30.5% of men and hypertension in 29.5%. These patients had participated in 1 of 5 previous 8-week or 12-week randomised, double-blind, placebo-controlled tadalafil studies. In the present trial, the starting 10mg dose of tadalafil could be increased to 20mg if the patient could not achieve satisfactory intercourse or reduced to 5mg for an adverse event that was persistent, intolerable and judged by the investigator to be related to tadalafil.

RESULTS:
Four hundred ninety-three (42.0%) men completed 24 months of treatment. In addition, a further 234 (19.9%) completed 18 months of treatment due to a sponsor decision to reduce the study duration. The total tadalafil exposure was 1676.0 patient-years. Tadalafil was safe and well tolerated. Headache (15.8%), dyspepsia (11.8%), nasopharyngitis (11.4%), and back pain (8.2%) were the most common treatment-emergent adverse events. The rate of discontinuations due to adverse events for this 18-24-month study was 6.3% and the rate for any individual event was <1%. Serious adverse events occurred in 8.6% of patients. No consistent pattern of serious adverse events assessed as causally associated with tadalafil administration was observed. None of the four deaths that occurred during the study was assessed as tadalafil related. There were no clinically significant laboratory or electrocardiographic findings or changes in vital signs in mean baseline-to-endpoint analysis attributable to tadalafil. Tadalafil administration was not causally associated with drug-induced hepatotoxicity, neutropenia, thrombocytopenia, or renal dysfunction.

CONCLUSION:
Tadalafil at doses of 5, 10, or 20mg taken as needed up to once daily for 18 to 24 months was safe and well tolerated. These findings support the long-term use of tadalafil in the clinical management of erectile dysfunction.

 

[Elvia1023]

One of the best drugs in the world just got better. Whilst I wouldn't go out and buy tadalafil for fat loss it's good to know it could be helping with it. Obviously I go out and buy it for the other 5 things it is amazing for

There only negative for me for tadalafil is frequent usage gives me nosebleeds. By frequent usage I men eod or ed for 1 week. The nose bleeds aren't bad but still occur. I have tested this out many times and it is 100% the tadalafil. Dbol does the same but x10. Nothing else gives me nosebleeds from my knowledge. Obviously this is just for me and most would not experience the same.

 

[johnjuanb1]

One of the best drugs in the world just got better. Whilst I wouldn't go out and buy tadalafil for fat loss it's good to know it could be helping with it. Obviously I go out and buy it for the other 5 things it is amazing for

There only negative for me for tadalafil is frequent usage gives me nosebleeds. By frequent usage I men eod or ed for 1 week. The nose bleeds aren't bad but still occur. I have tested this out many times and it is 100% the tadalafil. Dbol does the same but x10. Nothing else gives me nosebleeds from my knowledge. Obviously this is just for me and most would not experience the same.

Now if only they can tweak the molecular structure a bit to give you a Pringles can sized ding dong. Fat women around the world would be satisfied. :star-;ars:star-;ars

 

[stroker93]

Tried to buy some at your store but says everything is "Out of Stock"

 

[johnjuanb1]

Tried to buy some at your store but says everything is "Out of Stock"

I sent you a pm

 

[Massive G]

The only problem I have with cialis is the flushing. It's like niacin to me, but with out the itching and other sides. Once in a while I'll get stuffed up, but for the most part it's very tolerable -unlike viagra- very bad sides or levitra which is weak.
Face gets red as a beet, but then again so does the other head, and even though I am not on heavy doses - my prostrate gets inflamed and the cialis helps with that as well.
I was concerned about long term damage, that's why I searched the article.

It is also marketed as a drug to treat pulmonary hypertension as brand name Adcirca.

Pulmonary Hypertension Treatment Tadalafil (Adcirca) - Pulmonary Hypertension Association

 

[johnjuanb1]

The only problem I have with cialis is the flushing. It's like niacin to me, but with out the itching and other sides. Once in a while I'll get stuffed up, but for the most part it's very tolerable -unlike viagra- very bad sides or levitra which is weak.
Face gets red as a beet, but then again so does the other head, and even though I am not on heavy doses - my prostrate gets inflamed and the cialis helps with that as well.
I was concerned about long term damage, that's why I searched the article.

It is also marketed as a drug to treat pulmonary hypertension as brand name Adcirca.

Pulmonary Hypertension Treatment Tadalafil (Adcirca) - Pulmonary Hypertension Association

I never get any side effect from tadalifil even at 37.5mg
I guess that's an individual thing.

 

[Massive G]

I never get any side effect from tadalifil even at 37.5mg
I guess that's an individual thing.

Well hopefully you get at least "one" side effect!

I always love the story of viagra.
sildenafil citrate was being tested by pfizer as a possible life saving heart medication, was designed to get blood flow to the heart very very quickly after a heart attack.

during clinical trials the one side effect that got everyone's attention and changed the course of the world - the male pill was launched and created a revolution.
Let's just say they switched gears quite quickly on the label claim they were testing for.

 

[johnjuanb1]

Well hopefully you get at least "one" side effect!

I always love the story of viagra.
sildenafil citrate was being tested by pfizer as a possible life saving heart medication, was designed to get blood flow to the heart very very quickly after a heart attack.

during clinical trials the one side effect that got everyone's attention and changed the course of the world - the male pill was launched and created a revolution.
Let's just say they switched gears quite quickly on the label claim they were testing for.

They made a fortune and the stock in the company that sold caverject bottomed out. A guy I knew lost 3 million dollars over night by being heavily invested in caverject. Who wants to inject your penis when you can take a pill.
I love tadalifil. I have 20mg under my tongue right now getting ready for the gym.

 

[johnjuanb1]

Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice.
Varma A, et al. PLoS One. 2012.

Abstract

BACKGROUND: Insulin resistance impairs nitric oxide (NO) bioavailability and obesity promotes a state of chronic inflammation and damages the vascular endothelium. Phosphodiesterase-5 inhibitors restore NO signaling and may reduce circulating inflammatory markers, and improve metabolic parameters through a number of mechanisms. We hypothesized that daily administration of the PDE-5 inhibitor, tadalafil (TAD) will attenuate inflammation, improve fasting plasma glucose and triglyceride levels, body weight, and reduce infarct size after ischemia/reperfusion injury in obese, diabetic mice.

METHODS: Twenty leptin receptor null (db/db) mice underwent treatment with TAD (1 mg/Kg) or 10% DMSO for 28 days. Body weight and fasting plasma glucose levels were determined weekly. Upon completion, hearts were isolated and subjected to 30 min global ischemia followed by 60 min reperfusion in a Langendorff model. Plasma samples were taken for cytokine analysis and fasting triglyceride levels. Infarct size was measured using computer morphometry of tetrazolium stained sections. Additionally, ventricular cardiomyocytes were isolated and subjected to 40 min of simulated ischemia and reoxygenation. Necrosis was determined using trypan blue exclusion and LDH release assay and apoptosis was assessed by TUNEL assay after 1 h or 18 h of reoxygenation, respectively.

RESULTS: Treatment with TAD caused a reduction in infarct size in the diabetic heart (23.2 ± 1.5 vs. 47.8 ± 3.7%, p<0.01, n = 6/group), reduced fasting glucose levels (292 ± 31.8 vs. 511 ± 19.3 mg/dL, p<0.001) and fasting triglycerides (43.3 ± 21 vs. 129.7 ± 29 mg/dL, p<0.05) as compared to DMSO, however body weight was not significantly reduced. Circulating tumor necrosis factor-α and interleukin-1β were reduced after treatment compared to control (257 ± 16.51 vs. 402.3 ± 17.26 and 150.8 ± 12.55 vs. 264 ± 31.85 pg/mL, respectively; P<0.001) Isolated cardiomyocytes from TAD-treated mice showed reduced apoptosis and necrosis.

CONCLUSION: We have provided the first evidence that TAD therapy ameliorates circulating inflammatory cytokines and chemokines in a diabetic animal model while improving fasting glucose levels and reducing infarct size following ischemia-reperfusion injury in the heart.

PMID 23028874 [PubMed - indexed for MEDLINE] PMCID PMC3448606

 

[jolter604]

Good stuff