Technically there is no scientific proof of LR3 saturation and we have just been going off bro science this whole time. But many feel they get desensitized when running higher doses. Therefore lower doses like 20mcg lr3 maybe optimal long term. But what I’m wondering is if there could be any saturation with DES. Say maybe 25-50mcg post workout on workout days only. Maybe 3-4x a week. Could this be run year long with no saturation issues?