• All new members please introduce your self here and welcome to the board:
    http://www.professionalmuscle.com/forums/showthread.php?t=259
Buy Needles And Syringes With No Prescription
M4B Store Banner
intex
Riptropin Store banner
Generation X Bodybuilding Forum
Buy Needles And Syringes With No Prescription
Buy Needles And Syringes With No Prescription
Mysupps Store Banner
IP Gear Store Banner
PM-Ace-Labs
Ganabol Store Banner
Spend $100 and get bonus needles free at sterile syringes
Professional Muscle Store open now
sunrise2
PHARMAHGH1
kinglab
ganabol2
Professional Muscle Store open now
over 5000 supplements on sale at professional muscle store
azteca
granabolic1
napsgear-210x65
advertise1
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
ashp210
UGFREAK-banner-PM
esquel
YMSGIF210x65-Banner
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store

Take NAC with HCG!

Kaladryn

Featured Member / Kilo Klub
Featured Member
Kilo Klub Member
Registered
Joined
Jul 28, 2009
Messages
6,318
Anyone taking hCG should definitely add NAC to their program to prevent Leydig desensitization (always a problem when using HCG).

Differential modulation of apoptotic gene expression by N-acetyl-l-cysteine in Leydig cells stimulated persistently with hCG in vivo

The present study was designed to investigate the molecular mechanisms of NAC action in vivo under repeated hCG stimulation to adult rats. Leydig cell refractoriness led to a significant decline in serum testosterone and intracellular cAMP by day 30 of chronic hCG intervention which improved significantly following NAC co-administration. It inhibited the rise in lipid peroxidation, improved the activity of antioxidant enzymes along with intracellular glutathione and total antioxidant capacity in the target cells.

I edited out the dosage amounts because they do not apply to humans, you can see them in the original study, I wouldn't use this study as a dosing guide...
 
Last edited:
How about glutathione instead? Should work, ya?
 
How about glutathione instead? Should work, ya?

That is a pretty complex question I don't really have the knowledge to answer. Extracellular glutathione doesn't necessarily lead to intracellular glutathione for example.

There are great reasons to use glutathione besides this, so adding NAC on top of it would probably be reasonable.
 
For the sake of replication of a human equivalent dose of each would be, per this observation/study:

NAC• (150 mg/kg bw twice/week)

hCG• (100 IU/rat/day)

R=Rat

H=Human


Human equivalent dose of each:

NAC 300mg(6R/37H)=648>•90.718=4413.3081mg or roughly 4.4 grams twice per week. (Less total mg than average over a weeks time)

hCG 100ius(6R/37H)=16.216>•90.718=1471.1027ius or roughly 1.5ml of hCG daily. Yikes!:eek:
 

Attachments

  • image.jpg
    image.jpg
    25.6 KB · Views: 546
Last edited:
For the sake of replication of a human equivalent dose of each would be, per this observation/study:

NAC• (150 mg/kg bw twice/week)

hCG• (100 IU/rat/day)

R=Rat

H=Human


Human equivalent dose of each:

NAC 300mg(6R/37H)=648>•90.718=4413.3081mg or roughly 4.4 grams twice per week. (Less total mg than average over a weeks time)

hCG 100ius(6R/37H)=16.216>•90.718=1471.1027ius or roughly 1.5ml of hCG daily. Yikes!:eek:

Edit correction: for whatever reason I calculated 300mg of NAC.

Correction is as follows:

150mg(6/37)•90.718=2206.654mg or roughly 2.2grams.

Add in: 90.718 is figurative of a 200 pound man. 90.718kg=200 pounds.
 
How about glutathione instead? Should work, ya?

it doesn't go into the reason behind NAC so we don't really know if glut could be subbed.

NAC dose do things different the regular glut.

I took NAC for many years at high doses.

when we first got glut I tried that.
I used both for a while.
after some time I found that for general use they sort of felt redundant and I could get by with a minimum amount of glut and save the NAC for specific periods of time.

NAC is great for lung and breathing issues and if you get sick.

I also think if one were going to use orals that the combo of NAC and glut would be superior to either alone.

the last time I used orals, I used 600+ mg glut wk and like 1500mg NAC ed. I didn't have blood work done but felt great and no sides on up 300mg drol ed.
 
it doesn't go into the reason behind NAC so we don't really know if glut could be subbed.

NAC dose do things different the regular glut.

I took NAC for many years at high doses.

when we first got glut I tried that.
I used both for a while.
after some time I found that for general use they sort of felt redundant and I could get by with a minimum amount of glut and save the NAC for specific periods of time.

NAC is great for lung and breathing issues and if you get sick.

I also think if one were going to use orals that the combo of NAC and glut would be superior to either alone.

the last time I used orals, I used 600+ mg glut wk and like 1500mg NAC ed. I didn't have blood work done but felt great and no sides on up 300mg drol ed.

interesting i feel like ive been sucking for air and have been seeing a doc about the issue. i have some NAC kicking around I may add in the mean time.
 
By chance do you have routine phlebotomies, or the opposite?

Anyone in your family have emphysema or COPD?

interesting i feel like ive been sucking for air and have been seeing a doc about the issue. i have some NAC kicking around I may add in the mean time.
 
Nothings been found yet but i feel like we spent to much time just trying some inhalers before going to a specialist.

I still hope its i added to much weight and wasnt doing much cardio so im also working on dropping 20lbs and been doing cardio per my cardiologist.

Oh i did go to a cardiologist first we had ekg stuff and an echo done focusing on heart first. Had a stress test done where he said i did well he put me in a low dose beta blocker. I like this doc first guy who didnt try to scare me away from lifting but said if i could lean out to 240 and do my cardio in 140-145 hbpm range id work on heart health better. My bp would avg 128/75 before and now its 120/65. He was saying he liked his lifters on a low dose cause of the pressure us lifters put ourselves under during training.

It made sense to me and i feel better.

Now onto more cardio in mean time. Sorry for rambling but theres some smart people in the boards so if anyone wants to chime in plz do.
 
How's your red blood cell count? Do you or have you had multiple blood lettings (phlebotomy)? I'm leading up to looking more specifically at what your ferritin and saturation % is. Have they checked this?

I would ask if your cardiologist if s/he could pull a panel call A1AD (alpha 1 antitrypsin deficiency).
 
Last edited:
Edit correction: for whatever reason I calculated 300mg of NAC.

Correction is as follows:

150mg(6/37)•90.718=2206.654mg or roughly 2.2grams.

Add in: 90.718 is figurative of a 200 pound man. 90.718kg=200 pounds.

You type and sound(not littraly sound) the exact same as my O Chem2 teacher, never really understood what he was talking about either, but somehow manged to learn a ton from him.
.. Keep up the good work,it really is appreciated!!
 
Nothings been found yet but i feel like we spent to much time just trying some inhalers before going to a specialist.

I still hope its i added to much weight and wasnt doing much cardio so im also working on dropping 20lbs and been doing cardio per my cardiologist.

Oh i did go to a cardiologist first we had ekg stuff and an echo done focusing on heart first. Had a stress test done where he said i did well he put me in a low dose beta blocker. I like this doc first guy who didnt try to scare me away from lifting but said if i could lean out to 240 and do my cardio in 140-145 hbpm range id work on heart health better. My bp would avg 128/75 before and now its 120/65. He was saying he liked his lifters on a low dose cause of the pressure us lifters put ourselves under during training.

It made sense to me and i feel better.

Now onto more cardio in mean time. Sorry for rambling but theres some smart people in the boards so if anyone wants to chime in plz do.

240 lean is still pretty lean. How tall are you?
 
interesting i feel like ive been sucking for air and have been seeing a doc about the issue. i have some NAC kicking around I may add in the mean time.

depends on what is causing it. if my lungs feel like dirty or have a lot of shit in them then the NAC would be the way to go.

NAC can hinder endurance due to lowering lung pressure and a cpl other things.

so goes both ways.
 
BTW, I purposely left out dosing information because dosage is moot.

Desensitization of leydig cells is the number one problem with taking HCG. Any amount of NAC should help with this to a small extent, I would not use a unreasonable amount. I also would not go over 200-300iu of HCG per dose, and give yourself at least 72 hours between doses.
 
definitely agree on your last post...
leydig cell desentization only happens with huge doses of HCG all at once.

ive not yet seen any scientific evidence showing that amounts like 250-500iu twice a week cause any desensitization...

i dont understand why anyone would blast HCG in high dosages anyway.
it makes zero sense physiologically imo. the body is just not used to these amounts.

i agree that these guys blasting HCG the oldschool way would probably be better off using NAC.
 
Oral glutathione is poorly absorbed, It needs to be inhaled, injected, or as a dermal cream. Hence the need for NAC, which will convert. Stop wasting your money. Can add milk thistle as well, which has the side effect of stopping anxiety. . . .
 
Oral glutathione is poorly absorbed, It needs to be inhaled, injected, or as a dermal cream. Hence the need for NAC, which will convert. Stop wasting your money. Can add milk thistle as well, which has the side effect of stopping anxiety. . . .

well that why WE inject!!!!

:p:p:p
 
BTW, I purposely left out dosing information because dosage is moot.

Desensitization of leydig cells is the number one problem with taking HCG. Any amount of NAC should help with this to a small extent, I would not use a unreasonable amount. I also would not go over 200-300iu of HCG per dose, and give yourself at least 72 hours between doses.
I've been saying <500iu hCG per dose 3 times a week for so long I can't even remember. Maybe they'll listen to you.

I see 1000iu sometimes even more like 2000iu or the big 5000iu on here all the time and I just shake my head because those guys can probably forget ever going "off".
 
definitely agree on your last post...
leydig cell desentization only happens with huge doses of HCG all at once.

ive not yet seen any scientific evidence showing that amounts like 250-500iu twice a week cause any desensitization...

i dont understand why anyone would blast HCG in high dosages anyway.
it makes zero sense physiologically imo. the body is just not used to these amounts.

i agree that these guys blasting HCG the oldschool way would probably be better off using NAC.

Agreed.
 

Staff online

Forum statistics

Total page views
558,071,244
Threads
135,760
Messages
2,768,736
Members
160,343
Latest member
12cc
NapsGear
HGH Power Store email banner
your-raws
Prowrist straps store banner
infinity
FLASHING-BOTTOM-BANNER-210x131
raws
Savage Labs Store email
Syntherol Site Enhancing Oil Synthol
aqpharma
yourmuscleshop210x131
hulabs
ezgif-com-resize-2-1
MA Research Chem store banner
MA Supps Store Banner
volartek
Keytech banner
musclechem
Godbullraw-bottom-banner
Injection Instructions for beginners
Knight Labs store email banner
3
ashp131
YMS-210x131-V02
Back
Top