For those who might have missed this post before and for those who would like to know a little more about Kratom and the possible health benefits.
One of the most unique, and baffling, aspects of kratom effects is its ability to offer different results depending on dose. This action is caused by the vast array of different alkaloids typically found in Mitragyna speciosa which all have varying active dose ranges. We know more about some alkaloids than others and, owing to the lack of scientific study, there may be more alkaloids yet to be discovered that we do not know much about.
Here is a list of known kratom effects based on alkaloids:
Ajmalicine (Raubasine):
Cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer. Also found in Rauwolfia serpentina.
Akuammigine:
Ciliaphylline:
antitussive, analgesic.
< 1% of total alkaloid content found in Kratom leaf.
Corynantheidine:
μ -opioid antagonist
< 1% of total alkaloid content found in Kratom leaf.
Corynoxeine:
Calcium channel blocker.
< 1% of total alkaloid content found in Kratom leaf.
Corynoxine
A and B: Dopamine mediating anti-locomotives.
< 1% of total alkaloid content found in Kratom leaf.
Epicatechin:
Antioxidant, antiaggregant, antibacterial, antidiabetic,
antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant,
antiviral,
Could potentially help prevent cancer
9-Hydroxycorynantheidine:
Partial opioid agonist
7-hydroxymitragynine:
Analgesic, antitussive, anti diarrheal;
primary psychoactive in Kratom
about 2% of total alkaloid content found in Kratom leaf.
Isomitraphylline:
Immunostimulant, anti-leukemic.
< 1% of total alkaloid content found in Kratom leaf.
Isomitrafoline:
< 1% of total alkaloid content found in Kratom leaf.
Isopteropodine:
Immunostimulant
Isorhynchophylline:
Immunostimulant.
< 1% of total alkaloid content found in Kratom leaf.
Isospeciofoline:
< 1% of total alkaloid content found in Kratom leaf.
Mitraciliatine:
< 1% of total alkaloid content found in Kratom leaf.
Mitragynine:
Indole alkaloid. Analgesic, antitussive, anti diarrheal, adrenergic, antimalarial,
possible psychedelic (5-HT2A) antagonist.
Roughly 66% of total alkaloid content found in Kratom leaf.
Mitragynine oxindole B.
< 1% of total alkaloid content found in Kratom leaf.
Mitraphylline:
< 1% of total alkaloid content found in Kratom leaf.
Mitraphylline:
Oxindole alkaloid. Vasodilator, antihypertensive, muscle relaxer, diuretic, antiamnesic, anti-leukemic, possible immunostimulant.
<1% of total alkaloid contents in Kratom leaf.
Mitraversine
Paynantheine:
Indole alkaloid. Smooth muscle relaxer.
8.6% to 9% of total alkaloid contents in Kratom leaf.
Rhynchophylline:
Vasodilator, antihypertensive, calcium channel blocker,
antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic.
< 1% of total alkaloid content found in Kratom leaf.
Speciociliatine:
Weak opioid agonist.
0.8% to 1% of total alkaloid content of Kratom leaf, unique to Kratom
Speciofoline
Speciogynine:
Smooth muscle relaxer.
6.6% to 7% of total alkaloid contents of Kratom leaf.
Speciophylline:
Indole alkaloid. Anti-leukemic.
<1% of total alkaloid contents of Kratom leaf.
Stipulatine
Tetrahydroalstonine:
Hypoglycemic, anti-adrenergic (at alpha-2)
The above findings are mean values based on data from several studies. Kratom alkaloid content will vary markedly between strains and therefore kratom effects will likewise vary accordingly. Alkaloid content will vary between different locations around central Asia and will even vary dependent on the time of year the leafs are harvested. Having said this, we work with our suppliers to introduce new techniques to mitigate these differences which results in a similarly potent product all year round.
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