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Metformin with leucine...

Hulkbulk8

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Jan 3, 2013
Messages
679
I have read just about every article on PM about Metformin and all the benefits this drug offers. Very impressed! I see a lot of folks asking about it blunting mTor and lowering testosterone and effecting protein synthesis in a negative way.

I have a script for HRT so not worried about the testosterone issue. Why can't you just take a gram or two of leucine with each pill of metformin to counter the blunting of protein synthesis mtor?

I only take 500mgs twice a day but have been thinking about lowering my dose to 250mg with carb meals of 50g and with 100g carb meals I will do 500mgs

Would this lessen the negative impact on the mtor protein synthesis issue while still getting the benifits of metformin??

Any thoughts??
 
I've always figured mtor inhibition by metformin is negligible due to a bodybuilder diet so high in leucineyour
 
In theory, Leucine would help inhibit the decrease in mTOR via Metformin.

Another benefit of adding Leucine with Metformin is Leucine helps improve insulin sensitivity more-so than Metformin alone (rat study).
 
Sounds good. I would recommend 5g leucine per serving.
 
Does the dosing sound right....

50g carbs - 250mg metformin
100g carbs - 500mg metformin
150g+ carbs - 750-1g metformin

The most I will take is 1g metformin
 
Does the dosing sound right....

50g carbs - 250mg metformin
100g carbs - 500mg metformin
150g+ carbs - 750-1g metformin

The most I will take is 1g metformin

That seems to work, but...

Metformin builds up in your system(liver) so dose/timing is a bit overrated..hence the guys that take Met while on a keto diet.
 
My opinion is that if you're that worried about mTOR being affected and it ruining your size gains then DON'T TAKE METFORMIN! Easy solution.
 
But with the added leucine this should take care of that issue with mTOR.
I will just stick with smaller doses of metformin. The health benefits of this drug are amazing.

I also never feel that pump feeling folks talk about when they take metformin with a meal. There muscles become very full.
 
I make sure to take 5g of leucine with every meal anyway so I've already been doing this inadvertently. Only time I can't have the leucine is when I'm out and not home to put the teaspoon of leucine powder in my mouth.
 
I make sure to take 5g of leucine with every meal anyway so I've already been doing this inadvertently. Only time I can't have the leucine is when I'm out and not home to put the teaspoon of leucine powder in my mouth.

I'm goin to give this a try soon.
 
I make sure to take 5g of leucine with every meal anyway so I've already been doing this inadvertently. Only time I can't have the leucine is when I'm out and not home to put the teaspoon of leucine powder in my mouth.

I did this a while back and ended up gaining some good weight while on just HRT test. I lost some of my cuts though, could have been due to diet. Does leucine cause fat gain if you take with each meal? It's spikes insulin I noticed.
 
I make sure to take 5g of leucine with every meal anyway so I've already been doing this inadvertently. Only time I can't have the leucine is when I'm out and not home to put the teaspoon of leucine powder in my mouth.

what could ever go wrong carrying a baggie of white powder while you're out away from home?
 
That seems to work, but...

Metformin builds up in your system(liver) so dose/timing is a bit overrated..hence the guys that take Met while on a keto diet.

yeah op Hulkbulk8 it builds up and may take months for you to see full effects begin to take shape. stick with your original dose - don't cut it in half would be my vote.
 
I make sure to take 5g of leucine with every meal anyway so I've already been doing this inadvertently. Only time I can't have the leucine is when I'm out and not home to put the teaspoon of leucine powder in my mouth.
Good Shit bro. If you don't mind me asking what brand of leucine do you use? Some today but they want it like $20 for 60 mg...
yeah op Hulkbulk8 it builds up and may take months for you to see full effects begin to take shape. stick with your original dose - don't cut it in half would be my vote.


Sent from my SM-G935V using Tapatalk
 
don't worry about mTor for .5g of met . Take some citrulline instead..check this out and this is legit came out couple months ago

**broken link removed**
 
don't worry about mTor for .5g of met . Take some citrulline instead..check this out and this is legit came out couple months ago

**broken link removed**

That shit is hard to understand. Can someone dumb it down for me:D
 
Good Shit bro. If you don't mind me asking what brand of leucine do you use? Some today but they want it like $20 for 60 mg...



Sent from my SM-G935V using Tapatalk



I've used both Allmax and True Nutrition
 

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