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IP'S PGCL

allbeef

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Okay Bro's,

Lets take some of the mystery out of IP's PGCL.

First let me tell you that if you don't know, I have been a friend of IP
now for many years. I also would have been equally willing to post
negative or neutral comments about PGCL had I found the first results to
be dissappointing or the experience dangerous. This is a subjective post
and you must recognize, as I do, that this is pretty much uncharted
territory and no physician in his right mind would approve of these
methods for determining PGCL's effect or safety in bodybuiding MEN. The
literature on prostoglandins in bodybuilding is very limited. I was
greatly helped by articles on Basskiller and Mesomorphosis. You will note
in the literature reviews, that many times the dosing information is
choppy and you are not sure exactly which prostoglandin the author may be
referring to or which prostoglandin PGCL really is ( stronger or weaker ).
There is a ton of vetinary information out there on the drug that is used
to bring on heat and to induce labor in elephants, cattle, and pigs. But
it is hard to find information on fat metabolism, muscle growth, and
dosages in males.

IP's PGCL: It's ( PG-CL ) and each powder amp is 500 mcg or 1/2 mg.

THE PRICE: Pretty pricey although when one actually considers the
dramatic physique altering effects that occur with the drug and mild to
moderate workouts, it may be very cost effective. Certainly, when placed
side by side to HGH, PGCL appears to eliminate fat, at a rate many times
that of HGH. One of the most limiting factors of PGCL use appears to be as
spoken about elsewhere; the fact is that users get burned out with being a
pin cushion and to a lesser degree with the diarrhea that is induced by
the drug. Now IP tells me it can be taken at far lower frequencies ( 1
amp every two weeks ) and still be effective. This would truly make the
drug dirt cheap. In fact, IP is very concerned about the risks of dosing
schedules as high as mine, although I am very comfortable with the startup
schedule and dosages I used for the reasons given in this report. However,
if it can be shown to be equally effective when taken at lower dosages or
frequencies, then obviously that is preferred. AGAIN: This is pretty
UNCHARTED TERRITORY and use this drug at YOUR OWN RISK and ONLY
if you are a MAN! I would personally not use it if I was attempting to start
a family now or in the near future. It is one thing to take the risk on for
yourself, but I cannot see how you can in good conscience risk the health
of your baby to-be.

THE DOSAGE: I found that 1/4cc PGCL is a nice volume to shoot into a muscle
with an insulin syringe 29guage X 1/2 needle. You could use more or less
volume, but becuase there may be a small bite to the injection, it is
rather shallow injection, and there are more small nerves at shot
locations then you are use to with gear sticks, 1/4cc feels about right.
You clearly get the effects of the drug in what, appeared to me, to be
like-manner as when I used 3/4cc of PGCL. Besides, 1/4cc makes it easy to
split up in dosages that are suggested for a 220lb male ( approximately
37mcg ). Now I usually get bacteriostatic water from the lab supply store
to mix stuff with but I was lazy and I picked up Sterile Normal Saline Eye
Wash from the pharmacy section of the grocery store. IP has you buying
distilled water and microwaving it, which is cheap and can be easily done.
I just don't like gallon jugs as they quickly become breeding grounds for
bugs. So I used sterile normal saline and you can use sterile water.
Doesn't appear to matter although I am not an expert if you hadn't
noticed, LOL. You have many ways to get 12 insulin syringes filled at 1/4
cc from 1 amp of powdered PGCL to give you a shot with approximately
40mcg of drug in it. I personally use a clean one ounce drink shot glass that
has been submerged in ISOPROPYL ALCOHOL 91% for 5 minutes and then air
dried. With a sterile 3cc syringe, draw up just over 3cc of saline or water.
Break the top off the amp ( happy to report these Chinese glass amp tops break
easily as they are supposed to ) and put 2 cc in the amp and allow powder
to mix into solution. Then withdrawl everything out of amp with syringe and
you should be left with a syringe that has just over 3 cc's PGCL solution in it.
Shoot the 3cc's PGCL solution into the shot glass and draw up 12 insulin syringes
with 1/4cc ( or ml) PGCL each. You now have 12 shots available from one 500mcg
amp each. Each shot will have approximately 40 mcg's of PGCL which is the
recommended dose ( as far as I can find ) of PGCL for a 220lb MALE.

STORAGE: I kept the amps and the readied syringes in a refrigerator.
However, in reviewing the vetinary literature, I found that the drug in
solution may be kept in a dark place at room temperature. Obviously,
keeping the drug refrigerated for elephants in Africa would be a
challenge.

SHOOTING PGCL: Well it takes a little getting used to as it did the first
time you nailed yourself with a 1 1/2 inch 22 or 23 guage needle. It does
have a small bite at first and it varies depending on the muscle region
you are hitting as there are differences in where pain receptors are
between shot locations. But the worst pain that ( which isn't very bad ) is
the pain that you already know when you lay the needle close enough to a
nerve that the solution volume excerts pressure and you feel alittle pain
with inject. Thats why 1/4cc is a good shot volume as it isn't putting a
whole lot of volume pressure out at the point of inject. About every 10th
injection I did get a small ( dime-size ) bruise from needle/shot trauma.
This was ususually associated with jerking the syringe around or
repositioning the needle in the muscle using my left non-dominat hand.
You will find the bicep an easier muscle to hit the the tricep, DUH!. I
never aspirate back, but everyone will tell you you should.

THE DOSING SCHEDULE: I am just going to tell you what I did. I based my
inject sites, frequency, and dosage on what little literature was
available. BEAWARE::: It appears that I may be using well over twice the
necessary amount of drug needed. I shot ( two 40 mcg. injects ) 2 - 3
times a day ( 4 - 6 total shots ) depending on whether I was working that
day or not. On days that you are working you may have to scale back the
shots, or not do them at all, as the need to use the bathroom in quick
order is there everytime you inject. ON WORK DAY: I would do 1 shot at
work at a time when I knew that 20 minutes to 1 -1/2 hours after I
injected I could spend 1 - 3 ( 5 - 10 minutes breaks ) on the shitter
stinking the place up. I would then shoot some time after dinner being a
lttle sensitive to others in the house as far as smell and splatter ( if
you know what I mean!! ). ON NON WORK DAYS: I would do 2 shots,
3 times a day at times that made sense as far as ingestion of food and availability
of toilet. Now it is clearly a very fast acting drug and there is some
literature from bodybuilders suggesting shooting 5 times a day as the
anabolic effect may be as short as only 2 hours. May be my 6 shots on NON
WORK days should be spread out and limited to 5 shots total. But I am
afraid the logistics, as far as toilet use, and other tolerance issues,
make me comfortable with my shot schedule ( again that is ( 2 ) 40mcg
shots, 3 times a day where they make sense )

THE SHOT PAIN/SORENESS: You will read about having 64 possible shot
locations and the need to rotate the shots between muscles, locations and
workout days. I am going to tell you my experience is different. I am 6
days into it and shooting only my biceps and triceps. I did shoot my
chest once, my quads once and my calves once and the bowels moved about
the same degree with each location. It maybe becuase I am actually
hitting my system with 80 mcg with each inject session so proxcimity to
the guty may be a mute point as the shits going to roll ( or slip out of
you!! ) anyhow. I experience muscle soreness for about as long as the drug
remains active which I would guesstimate at 1-3 hours. I have experienced
nothing debilitating as far as muscle pain and I can inject the muscle
over and over again. I can work the muscle moderately hard, get a great
pump, without any consideration of whether I shot the muscle that day or
not. Now your experience may be different as I know from experience with
shooting IP's oils forever it seems that while I rarely ever had
sensitivity some guys would get tremendous adverse reactions at the
injection site. DO YOU UNDERSTAND: That I shoot two shots into the
identical areas of the bilateral muscle with every shot episode. So during
the 1 -3 sessions a day, I shoot one bicep or tri area and then try to
shoot immediately the same area on the other arm. Thats how I get 80mcg's
of drug with every inject session.

WHAT ELSE AM I ON: I am on HRT and don't cycle anymore as I can't
grow on cycles that include up to 2 grams of test a week. I am over 50 and my
test levels are managed by a physician who uses lozenges to keep me at a
level of someone about 30. You will never grow on HRT, but if you time it
right sometime after 40 when your muscle mass starts to dwindle, get on it
and you may blunt the muscle loss. How long??? we will find out!!! I
also take armidex and procepia, but that is really it. Oh I am doing PWO
slin and Maxy Waize just to augment the muscle fullness if I can. Only on
workout days. I do 75mg -100 mg of ephedrine HCL preworkout and I have
noticed a blunted effect of ephedrine since being on PGCL. I would say 30%
less of a boost.

THE SHOT LOCATIONS: Like I said above, I am not rotating muscles beyond
the two I have chosen to experiment on. My Biceps and my Triceps. I am
only doing the lateral head of the triceps for reasons that will become obvious
to you when you go to hitting the tricep muscle by yourself.

*********************************************************
THE SIDE EFFECTS:

Your experience may be different and my experiment may be dangerous for
some MALES. In fact, IP is very concerned about the risks of dosing
schedules as high as mine although I am very comfortable with the schedule
and dosages I used for the reasons given in this report. However, if it
can be shown to be equally effective when taken at lower dosages or
frequencies then obviously this is preferred. AGAIN: This is pretty
UNCHARTED TERRITORY and use this drug at YOUR OWN RISK and ONLY
if you are a MAN! I would personally not use it if I was attempting to start
a family now or in the near future. It is one thing to take the risk on for
yourself, but I cannot see hopw you can in good conscience risk the health
of your baby to-be.

THE SCARIEST EFFECT: Was on the first or second day of use when doing
shrugs, on about the 4th set the area around my adam's apple started to
tighten up. Now the first thought is that the airway could close down as
with anaphalactic shock. I stopped the exercise and the sensation quickly
subsided. That was the only time I experienced that feeling. PGCL is a
smooth muscle constrictor and today I think I may have just triggered some
smooth muscle in my neck or possibly the lower windpipe to contract.
Understanding it doesn't make it any safer, if your airway should close
off, you won't be worrying about muscle size anymore.

NAUSEA: Truthfully, it was only the first day that I almost felt ( when
the drug was peaking in my system, around 1 hour or so ) like vomiting.
I didn't, it never got to the point of heaves. That 1st and 2nd day was
one of fatique and a feeling of sickness mostly when the drug was peaking.

THE SHITTER: This is probably the biggest nuisance, but may also be one
of the most beneficial aspects of the drug. You will need a bathroom for
diarrhea 1 - 3 times within the 1st 20 min to 1 1/2 hours after injecting
the dosages I used. The drug causes spontaneous abortions in females
through smooth muscle contractions. In men this drug causes you to
spontaneously abort much of what you have in your GI track, as well as,
your bladder through the same mechanism. It doesn't seem to get better,
it happens everytime, and there were a couple times that I would have shit
my pants ( at work ) if I did not have a toilet readily available. The good
news is ( despite a puckered asshole, LOL ) you develop a tolerance and it
becomes a fairly easy thing to manage, but how many times can you admit
to your family in a week period, you have the runs? Seems a little weird!!

BODYTEMP: You read about sweating and increase in body temperature when
people are describing the effects when drug is peaking in your system. In
my experience I had a consistent drop in body temperature 36.3 - 36.9
degrees celcius when peaking ( at about 1 hour or when you are compelled
to the bathroom ). Much of the day my hands and feet where cold and so it
appears to me that I peripherally shut down due to vasoconstriction of
blood vessels in my hands and feet. It may be a compensatory reaction to
the sudden loss of water volume intravascularily through the massive
shifting of water into the GI tract causing, near-explosive, diarrhea.
Just speculation as is all of this report.

SITE PAIN / MUSCLE SORENESS: As noted above: small bite with injection,
soreness for me while drug levels were high and nothing that prevents me
from working that muscle or re-hitting the site.

CRAMPING: Some cramping thats confined to the hands mostly every
day once or twice that subsides. I attributed this to electrolyte loss from
diarrhea and diuresis.

BRUISING: Like I said above, small, dime-size, bruises about every 10th
inject from muscle trauma I speculate was cuased by me jerking the syringe
and needle around with my non-dominant hand.

*********************************************************

THE RESULTS:

WEIGHT LOSS: In 5 days, I lossed 9 lbs. Much of this was water, but it was
also significantly fat. Vascularity has been brought out by a reduction of
the fat sheath on arms and legs. Belt size shortened about 1 inch.

ARM SIZE: In 5 days, approximately 1 inch, added to my Bicep/tricep
measurement post workout of the arms. About 18 to 19 inches with the
muscle staying fuller throughout day. Come on,,, I am over 50, how big did
you think I would be??? bigger than most!!

HORNYNESS: Some users of prostoglandins report increase in Libido. I
would say mine was enhanced slightly, but this maybe more of a placebo
effect. In younger men this effect maybe more pronounced or it may not
have any effect on libido.

PURELY SPECULATION / BABBLING

What makes this drug so interesting for rapid weight loss is that you are
emptying the gut periodically throughout the day and depriving the body of
calories and electrolytes. However unlike caloric restrictive diets
of say, less that 1000 calories a day, you are able to eat normally ( if
not overeat ) and not suffer through the psychological pain of strict
dieting. You may also prevent the re-setting of the metabolism that occurs
when the body thinks you are depriving it. But I am convinced, that in
addition to diuresis, the drug is causing food in the small intestine to
not get fully absorbed, but be evacuated out of the body. Whether there
is actually increased fat metabolism occuring ( the burning up or
"killing" ) of fat cells that one reads about from prostoglandins I can't
tell. I do not see heat occuring which would lead me to believe that my
metabolism was increased. I do see one of the most pain free and profound
weight loss through diuresis and decreased nutritional absorbtion that I
have ever experienced, or heard of. If you are a fighter trying to make
weight, take 80 mcgs of PGCL, and within 2 hours you maybe as much as 5
pounds lighter. One gallon of water weighs 8 lbs and I didn't weigh it,
LOL, but that first shot/shit was about 1 /2 gallon of pretty toxic stuff.
I would certainly consider gatoraid/pedi-lite drinks throughout day if
in fact, we agree there is a serious loss of electrolites ocurring. There
is obvious muscle swelling due to inflamation of the muscle. How can this
be anabolic?? It is fluid! It must be stretching fascia? But is it
anymore stretching than if I was on 2 grams of test?? Time will tell. I
have 5-6 more amps to do in my arms. What are the health consequenses in
men?? Hell I don't know, but in rats given tons of the drug, it appears
that any negative effects subsided with discontinuation of the drug.
Tolerance issues: most people seem to tolerate and learn to manage the
shitter, but it appears that 2 months is the maximum that people want to
be a pincushion or to just manage the logistics associated with PGCL. My
intuition tells me that I will do 8 amps into my Biceps and Tris and then
take a break and evaluate the longer term effects. I think a 10amp
package for $250 from China and 500mg of test a week will get you a 1-2
month bridging cycle between steroid use. IP tells me he may bring this
price down and both he and the remailers will be stocking up on PGCL in
the next couple weeks.


IN SUMMARY: I have done DNP and could not tolerate it beyond day two. It
was probably the most frightening experience along with just the
discomfort from heat. DNP is nasty stuff and frommy perspective the kind
of stuff physiologically that if you show up in the ER with serious side
effects, they aren't going to have a clue other than ice packs as to how
to treat you. In other words they are as apt to turn the negative effects
up as much as turn them down. It wouldn't surprise me if death occurs
occaissionally with DNP use. I have used as much as 700ius of HGH over a
few months and while I did recognize fat loss, it came at a significant
price.

No this is very interesting stuff that I think warrants a try without more
than base test, and without HGH. It is cool stuff in that you can
painlessly diet and ( with a little site pain ) manipulate muscle size all
within a matter of days.

I do not know if the muscle swelling will occur in people with little or
no muscle mass. I suspect that like steroids, there won't be much of a
size increase without mass.

Well did I seem biased??? I hope not!! I am IP's friend, but money has
never motivated me to compromise Truth. In fact I paid full price for the
product which is extremely rare for me. This is all subjective and in the
end I only hope I have just provided some helpful information that will
allow you to safely experiment with this very unique drug. For God's
sake people, do you realize I am reporting all this after only 5 days or
2-3 amps 1mg - 1.5 mg PGCL. I will give you the full, blow to blow,
through 5 more amps so that this is not just some great beginning followed
up without an ending reported.


Allbeef
 
Last edited:
Thanks for the report bro. Been looking at this stuff for a while now. Have only talked with a few that have used it, and all of them have been very happy/surprised with it. Will look forward to your future reports.
 
Good thread!! Your thread is pretty muc right on with how I felt when useing it. I only used it once though. I dont know if I would ever use it again because with my job it would just make it pretty hard.
 
So, was it really worth it? Im looking into ordering some now, mainly for fat loss, site enhancement and muscle hardness it claims to bring.
 
Grunt76 said:
Thanks for the detailed report. This is PGF2a, aka Dinoprost Thromethamine, aka lutalyse, right?
I sure hope not, Lutalyse is $8 for 150mg. PG-CL is $200 for 4mg.

Very nice write up allbeef. If possible could you find out exactly which prostaglandin this is that IP is selling?

In chemistry PG is the abbreviation for prostaglandin, then different compounds are shown by adding an alphabetic letter to indicate the type of ring structure. A number is then subscripted to show the number of hydrocarbon skeleton double bonds.

Known prostaglandins are:

Prostaglandin A1
Prostaglandin A2
Prostaglandin B1
Prostaglandin B2
Prostaglandin C1
Prostaglandin C2
Prostaglandin D1
Prostaglandin D2
Prostaglandin E1
Prostaglandin E2
Prostaglandin E3
Prostaglandin F1alpha
Prostaglandin F2alpha
Prostaglandin F2beta
Prostaglandin F3alpha
Prostaglandin G2
Prostaglandin H2
Prostaglandin I2
Prostaglandin J2
 
What about subq. injections to kill the fat cells?...it works or is only speculation?
 
Koevoet said:
I sure hope not, Lutalyse is $8 for 150mg. PG-CL is $200 for 4mg.

Very nice write up allbeef. If possible could you find out exactly which prostaglandin this is that IP is selling?

In chemistry PG is the abbreviation for prostaglandin, then different compounds are shown by adding an alphabetic letter to indicate the type of ring structure. A number is then subscripted to show the number of hydrocarbon skeleton double bonds.

Known prostaglandins are:

Prostaglandin A1
Prostaglandin A2
Prostaglandin B1
Prostaglandin B2
Prostaglandin C1
Prostaglandin C2
Prostaglandin D1
Prostaglandin D2
Prostaglandin E1
Prostaglandin E2
Prostaglandin E3
Prostaglandin F1alpha
Prostaglandin F2alpha
Prostaglandin F2beta
Prostaglandin F3alpha
Prostaglandin G2
Prostaglandin H2
Prostaglandin I2
Prostaglandin J2


Well IP himself claims that its a synthetic version of some sort, and is 50 times more potent than regular PGF-2a, which would explain concentration and price pretty much. Besides lutalyse is already a solution, it is not 150 mg of pure PGF-2a in there, whereas in the IP amps what you get is pure PGCL which you dissolve yourself.
 
Last edited:
vadim_b1 said:
Well IP himself claims that its a synthetic version of some sort, and is 50 times more potent than regular PGF-2a, which would explain concentration and price pretty much. Besides lutalyse is already a solution, it is not 150 mg of pure PGF-2a in there, whereas in the IP amps what you get is pure PGCL which you dissolve yourself.
I care less about the marketing, what is the chemistry behind it?

While Lutalyse is in a solution that in and of itself is meaningless, you get 150mg of dinoprost tromethamine in that solution, which is equilalent to 150mg of dinoprost, which happens to be the name for synthetic PGF2a.

So a single 30ml bottle of Lutalyse contain 150mg of synthetic PGF2a.

So now what exactly is PGCL, and why does it cost almost 1000 times more than PGF2a?
 
Koevoet said:
I care less about the marketing, what is the chemistry behind it?

While Lutalyse is in a solution that in and of itself is meaningless, you get 150mg of dinoprost tromethamine in that solution, which is equilalent to 150mg of dinoprost, which happens to be the name for synthetic PGF2a.

So a single 30ml bottle of Lutalyse contain 150mg of synthetic PGF2a.

So now what exactly is PGCL, and why does it cost almost 1000 times more than PGF2a?
Bumping these very good and valid questions. Interest is real.
 
Hey Guys

Those are great comments and reasonable price concerns. I think there is a lot of information about fat and PGF2a which should apply. I also thought the price was high, but a little looking around tonight led me to believe otherwise. Unless I am wrong about the drug ( which I could be ) IP's claim of potency above PGF2a may be well founded.

--------------------------------------------------------------------------

I have an email out to IP. I am not an expert and it is pretty obvious that there aren't many experts around. But I do think I have identified the drug. I just want to get IP's response before I go much farther.

**********************************************************
What it appears it is not: LUTALYSE® (dinoprost tromethamine)
--------------------------------------------------------------------
IF I AM CORRECT:

PG-CL is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. PG-CL is the optically active, 15(R) enantiomer of PG-CL is responsible for the majority of its biological activity. PG-CL is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2α. The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 µg/kg and 270 µg/kg in hamsters and rats, respectively.


AND THE PRICING:

Now you may find it a little cheaper, but this is pricing from a CAYMEN CHEMICAL COMPANY and a review of other chemical suppliers worldwide doesn't show it getting a whole lot cheaper. You can bet IP gets it cheaper than anyone.


PG-CL
Size Price
1 mg $37.00
5 mg $167.00
10 mg $296.00
50 mg $1,295.00
Pricing updated 2007-03-26.
Prices are subject to change without notice.
-------------------------------------------------------------------------

Off Ironman Board: The Only Post in Thread 2004: Talking about topical Application of PGF-2a

PGF-2a kills fat cells

( Note Allbeef: PG-CL is a synthetic analog of prostaglandin F2α (PGF2α).)
------------------------------------------------------------------------
Prostaglandin F2alpha is a potent inhibitor of adipocyte precursor differentiation and a physiological negative modulator of adipocyte function (ie triglyceride accumulation) through stimulation of transforming growth factor-alpha mRNA expression. It initiates a cascade of effects in the adipoctes which have physiological importance to reducing the size and it appears number of mature cells,long after PGf-2a is cleared from the system

Mature adipose cells only shrink in size in response to restricted caloric intake or increased metabolic demand. Before now the only method of reducing the number of fat cells was liposuction. It now appears that Pgf-2a applied topically can have the same same effecst as diet and liposuction. Pgf-2a can reduce the size of mature adipocytes and the number of mature adipocytes through negative modulation and reversing the process of differentiation.

It is important to remember that dinoprost tromethamine does not burn the released fatty acids, aerobic exercise and or T3 will take care of that. PGF-2a only changes the way fats are stored and the formation and function of adipose tissue. As well I find that about half of the time I feel a tickle in the back of my throat and sometimes I have a full out coughing fit. This says to me that I have applied a good dosage.

Here are some studies that support PGF-2a and negative modulation of adipose tissue.

Endocrinology 1995 Aug;136(8):3222-9

Prostaglandin F2 alpha stimulates transforming growth factor-alpha expression in adipocyte precursors.

Lepak NM, Serrero G.

W. Alton Jones Cell Science Center, Inc., Lake Placid, New York 12946, USA.

Transforming growth factor-alpha (TGF alpha) and prostaglandin F2 alpha (PGF2 alpha) are potent inhibitors of adipocyte differentiation. We demonstrate here that TGF alpha messenger RNA (mRNA) is expressed in freshly isolated fat pads and in primary culture of adipocyte precursors cultivated in defined medium before and after differentiation. We show that PGF2 alpha stimulated TGF alpha mRNA expression in a dose-dependent manner. PGF2 alpha also stimulated TGF alpha production in the culture medium of adipocyte precursors in primary culture. PGF2 alpha stimulated TGF alpha mRNA expression in both undifferentiated and differentiated cells. 9 alpha,11 beta-PGF2 alpha, which also inhibited adipose differentiation, stimulated TGF alpha mRNA expression similarly to PGF2 alpha, whereas other PGs had no effect on TGF alpha mRNA expression. The time-course experiment indicates that the stimulation of TGF alpha mRNA expression by PGF2 alpha is observed within 6 h of exposure to PGF2 alpha and is inhibited by treatment of the cells with actinomycin D. The effect of PGF2 alpha on TGF alpha expression did not require activation of protein kinase C and was fully reversible. As both TGF alpha and PGF2 alpha are inhibitors of adipose differentiation, it is suggested that stimulation of TGF alpha expression by PGF2 alpha could represent an amplification mechanism to modulate adipocyte precursor differentiation and adipocyte function within the adipose tissue.

Int J Obes Relat Metab Disord 1996 Mar;20 Suppl 3:S58-64 R

Endocrine and paracrine negative regulators of adipose differentiation.

Serrero G, Lepak N.

W Alton Jones Cell Science Center, Inc, Lake Placid, NY 12946, USA.

Obesity which is characterized by an abnormal adipose tissue development is a first degree public health hazard in industrialized countries. One important aspect in the study of adipose tissue development is to investigate the hormonal control of proliferation and differentiation. Any qualitative or quantitative change in these hormones or their receptors can result in abnormalities in the process of proliferation and/or differentiation possibly leading to obesity. Therefore, it is important to identify these factors and investigate their mechanism of action. We have concentrated our efforts in the study of factors triggering differentiation (positive regulators) and also of factors inhibiting differentiation (negative regulators). The present paper provides evidence of the importance of EGF/TGF-alpha and of PGF2 alpha as differentiation inhibitors for adipocyte precursors in primary culture. Data presented here also demonstrate that TGF-alpha is expressed in adipose tissue and that its expression is specifically stimulated by PGF2 alpha, thus suggesting the existence of an amplification mechanism between two differentiation inhibitors within the adipose tissue. The importance of these two types of differentiation inhibitors in the regulation of adipose tissue development is discussed.


Allbeef
 
Ok...I bought 8 amps just yesterday...I think will wait a pair of weeks for delivery...

About usage for this period I think will do something totally different from you...in the next 2 months I can't train and eat like I want due to some work and family issues,so I will concentrate my goal only in reducing bodyfat...in fact if subq inj of pgcl can kill fat cells I think will achieve great results even if I don't train or diet...

I will start with low doses...I think not more than 50 mcg daily splitted in 2 times(when I can reach without problems bathroom...so the hour can probably change everyday)and half on each side so that fat reducing will be simmetrical...

I will inject it in middle section to reduce total fat and my love handles..and probably in glutes...I know is strange but I gain fat like a pussy...thighs and glutes...now I am totally not lean and pretty fat in all my body,but even when I am dieting and get lean,when I have good ripped abs my glutes and thighs are still fat...so I will give a try in the glutes because this part have the highest amount of fat and if works maybe do in thighs too...

Do you have some advice about???
 
PGF2a Transdermal?

Could this product be used to make a transdermal with say isopropyl alcohol & propylene glycol? Sorry, I'm not a fan of atomic shitz! I have also heard that the transdermal is much easier on the GI sides.
Have a contest coming fairly soon and wouldn't mind killing some fat cells here and there:D
 
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Ive ordered 12 amps too, so expect some feedback from me too in a while.
 
allbeef said:
Those are great comments and reasonable price concerns. I think there is a lot of information about fat and PGF2a which should apply. I also thought the price was high, but a little looking around tonight led me to believe otherwise. Unless I am wrong about the drug ( which I could be ) IP's claim of potency above PGF2a may be well founded.

IF I AM CORRECT:

PG-CL is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. PG-CL is the optically active, 15(R) enantiomer of PG-CL is responsible for the majority of its biological activity. PG-CL is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2α. The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 µg/kg and 270 µg/kg in hamsters and rats, respectively.
I believe I see where I was confused. PG-CL is not a prostaglandin itself, it is a racemic analog of PGF2a which explains the increased potency and price.

Very interesting. Having used PGF2a, I am looking forward to trying some PG-CL myself.
 
Koevoet said:
I believe I see where I was confused. PG-CL is not a prostaglandin itself, it is a racemic analog of PGF2a which explains the increased potency and price.

Very interesting. Having used PGF2a, I am looking forward to trying some PG-CL myself.

Koevoet, what were your results like when you were using the pgf2a?
 

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