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One of the first questions many have regarding SARMs is “Do SARMs cause hair loss?”
All SARMs can cause hair loss.
The extent to which they can cause it is based upon their own inherent tissue selectivity and androgenicity.
There is no SARM as of now that is completely selective for anabolic to androgenic activity in the body.
Some dosage for every SARM no matter which it is will induce prostate growth, which in turn will likely have an effect on the hair follicles on your head, facial hair growth, and other virilization side effects.
Typically, if somebody starts losing hair on SARMs it is the result of telogen effluvium, or using a high dosage of SARM way beyond what the probable therapeutic dosage would be established at.
While SARMs can cause hair loss, they can also prevent hair loss.
At least in theory they can prevent hair loss, as there is no clinical study to assess this specifically.
Anecdotally, if you reverse engineer how SARMs work you can see how they're going to play out in a hair loss prevention context.
SARMs were created to replace the therapeutic anabolic benefits of testosterone on muscle tissue and bone.
The dosage at which many SARMs in clinical development fulfill and hit that threshold of therapeutic activity not only suppress the endogenous production of testosterone, but they compete with Testosterone and DHT for the androgen receptor (AR).
By suppressing systemic Testosterone levels in the body and competing with Testosterone and DHT for the androgen receptor, androgenic activity in the body is substantially decreased.
This reduces prostate size and can potentially also reduce hair loss.
SARMs Usage In Humans To Prevent Hair Loss?
The more tissue selective of a compound used on a research subject, the more efficacious it is for potential hair loss prevention.
Let's just say you have a SARM with 500 to 1 anabolic to androgenic ratio of selectivity.
Testosterone’s anabolic to androgenic ratio is 1 to 1.
With the SARM, you could theoretically keep muscle tissue and bone maintenance at therapeutic levels while simultaneously nuking testosterone and DHT via the suppression of natural testosterone level in the body.
The SARM would also occupy androgen receptors with a greater affinity than Testosterone and DHT, which would prevent AR mediated androgenic activity to a large extent.
Concurrently while those two things are happening, you indirectly reduce hair follicle miniaturization.
Lower androgen index = decreased prostate size = decreased hair loss.
Therefore, the answer to the question “do SARMs cause hair loss” is both yes and no.
All SARMs can cause hair loss.
The extent to which they can cause it is based upon their own inherent tissue selectivity and androgenicity.
There is no SARM as of now that is completely selective for anabolic to androgenic activity in the body.
Some dosage for every SARM no matter which it is will induce prostate growth, which in turn will likely have an effect on the hair follicles on your head, facial hair growth, and other virilization side effects.
Typically, if somebody starts losing hair on SARMs it is the result of telogen effluvium, or using a high dosage of SARM way beyond what the probable therapeutic dosage would be established at.
While SARMs can cause hair loss, they can also prevent hair loss.
At least in theory they can prevent hair loss, as there is no clinical study to assess this specifically.
Anecdotally, if you reverse engineer how SARMs work you can see how they're going to play out in a hair loss prevention context.
SARMs were created to replace the therapeutic anabolic benefits of testosterone on muscle tissue and bone.
The dosage at which many SARMs in clinical development fulfill and hit that threshold of therapeutic activity not only suppress the endogenous production of testosterone, but they compete with Testosterone and DHT for the androgen receptor (AR).
By suppressing systemic Testosterone levels in the body and competing with Testosterone and DHT for the androgen receptor, androgenic activity in the body is substantially decreased.
This reduces prostate size and can potentially also reduce hair loss.
SARMs Usage In Humans To Prevent Hair Loss?
The more tissue selective of a compound used on a research subject, the more efficacious it is for potential hair loss prevention.
Let's just say you have a SARM with 500 to 1 anabolic to androgenic ratio of selectivity.
Testosterone’s anabolic to androgenic ratio is 1 to 1.
With the SARM, you could theoretically keep muscle tissue and bone maintenance at therapeutic levels while simultaneously nuking testosterone and DHT via the suppression of natural testosterone level in the body.
The SARM would also occupy androgen receptors with a greater affinity than Testosterone and DHT, which would prevent AR mediated androgenic activity to a large extent.
Concurrently while those two things are happening, you indirectly reduce hair follicle miniaturization.
Lower androgen index = decreased prostate size = decreased hair loss.
Therefore, the answer to the question “do SARMs cause hair loss” is both yes and no.
