19nor + HGH = What?

[Aburaihan]

Ive read that tren has a positive effect of igf1.

But see on bloodwork, tren can be the cause of a low igf reading?

Tren and gh synergy or no?

 

[MyNameIsJeff]

You have to distinguish between IGF1 signalling in the target tissue and IGF1 serum levels. Trenbolone increases muscle cells' responsiveness to IGF-I but decreases IGF1 production in the liver. These two effects seem to cancel each other out, so that IGF1 mRNA levels are unchanged following trenbolone only treatment.

With Tren + Estradiol treatment on the other hand, IGF-1 mRNA levels do increase. This is likely due to greater IGF-1 production in the liver. Note that Estrogen is an important factor for IGF-1 production in the liver. Furthermore, Estrogen serum levels and signalling in a target tissue like the liver is decreased by androgens. Hence, a corresponding increase in estrogen levels is needed to maintain IGF-1 production in the presence of Trenbolone, thereby leading to increased IGF1 mRNA levels.

See https://www.researchgate.net/public..._and_androgen_receptor_messenger_ribonucleic_ and a couple other papers that Im too lazy to dig up right now.