Does metformin decrease high hematocrit?

[warlock]

Diabetes Care. 2012 Apr;35(4):731-7. doi: 10.2337/dc11-1299.

Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study.
Diabetes Prevention Program Research Group
Collaborators

Author information

Abstract

OBJECTIVE:
Metformin produced weight loss and delayed or prevented diabetes in the Diabetes Prevention Program (DPP). We examined its long-term safety and tolerability along with weight loss, and change in waist circumference during the DPP and its long-term follow-up.

RESEARCH DESIGN AND METHODS:
The randomized double-blind clinical trial of metformin or placebo followed by a 7-8-year open-label extension and analysis of adverse events, tolerability, and the effect of adherence on change in weight and waist circumference.

RESULTS:
No significant safety issues were identified. Gastrointestinal symptoms were more common in metformin than placebo participants and declined over time. During the DPP, average hemoglobin and hematocrit levels were slightly lower in the metformin group than in the placebo group. Decreases in hemoglobin and hematocrit in the metformin group occurred during the first year following randomization, with no further changes observed over time. During the DPP, metformin participants had reduced body weight and waist circumference compared with placebo (weight by 2.06 ± 5.65% vs. 0.02 ± 5.52%, P < 0.001, and waist circumference by 2.13 ± 7.06 cm vs. 0.79 ± 6.54 cm, P < 0.001 in metformin vs. placebo, respectively). The magnitude of weight loss during the 2-year double-blind period was directly related to adherence (P < 0.001). Throughout the unblinded follow-up, weight loss remained significantly greater in the metformin group than in the placebo group (2.0 vs. 0.2%, P < 0.001), and this was related to the degree of continuing metformin adherence (P < 0.001).

CONCLUSIONS:
Metformin used for diabetes prevention is safe and well tolerated. Weight loss is related to adherence to metformin and is durable for at least 10 years of treatment.

https://www.excelmale.com/showthread.php?9777-Metformin-decreases-high-hematocrit

 

[nothuman]

Doesn't decrease mine at all unfortunately, and I use 1500mg daily.

 

[chainheart]

metformin may lower hematocrit in non AAS users. i have used metformin for many years and it has had no effect in lowering my hematocrit.

 

[LEX]

metformin may lower hematocrit in non AAS users. i have used metformin for many years and it has had no effect in lowering my hematocrit.

Bingo.

 

[Stewie]

I posted this in Nelson's post on Facebook.

I've used metformin for quite some time. I haven't noticed any significant lowering effects on my HH.

I would believe testosterone's effects on ethroprotien synthesis, metformin would have no significant effect on one's HH.

The study design is looking at obese T2D. These individuals may of had improvement with hypoxia episode's, thus a reduction in ethroprotien synthesis. OSA is highly seen in obese individuals.

That's my personal hypothesis.

Dr. Saya agreed with my opinion.