"Losartan often failed to control blood pressure all day, but this information was not widely known. I recommended to members that they check their blood pressure 12 to 15 hours after taking losartan and many reported back that they needed to take it twice daily."
with 150/100 you definitely want to take losartan twice daily. if your diastolic/bottom number is that high on a regular basis you better be on another bp med.
nothuman turned me on to telismartin. he wrote
"Improves insulin sensitivity, enhances mitochondrial activity, improves endothelial function, fat loss, and increases longevity. 40mg daily (split 20mg morning and night) " and here are two links he posted:
Best Drug To Treat Hypertension - Life Extension
https://thinksteroids.com/steroid-profiles/telmisartan/
P.S.
losartan is also used to slow long-term kidney damage in people with type 2 diabetes who have high blood pressure.