Buy Needles And Syringes With No Prescription
M4B Store Banner
intex
Riptropin Store banner
Generation X Bodybuilding Forum
Buy Needles And Syringes With No Prescription
Buy Needles And Syringes With No Prescription
Mysupps Store Banner
IP Gear Store Banner
PM-Ace-Labs
Ganabol Store Banner
Spend $100 and get bonus needles free at sterile syringes
Professional Muscle Store open now
sunrise2
PHARMAHGH1
kinglab
ganabol2
Professional Muscle Store open now
over 5000 supplements on sale at professional muscle store
azteca
granabolic1
napsgear-210x65
advertise1
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
ashp210
UGFREAK-banner-PM
esquel
YMSGIF210x65-Banner
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store

Using Melanotan II to mediate HGH induced insulin resistance

johnjuanb1

Featured Member / Sponsor Rep
Featured Member
Kilo Klub Member
Registered
Sponsors
Joined
Mar 6, 2009
Messages
25,969
Insulin resistance is an ongoing battle for those of us using HGH. Melanotan II has been shown to increase insulin sensitivity and reduce insulin resistance


Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats.
Banno R, et al. FEBS Lett. 2007.
Show full citation
Abstract
In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats.
Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.
 
Three things:

1) I think you mean 'ameliorate' rather than mediate?

2) When they say the effect on insulin sensitivity (IS) is significant, they probably mean statistically significant. So whether the effect is practically relevant is hard to say without reading the study.

3) Based on this abstract, MT2 increases IS of fat cells rather than muscle cells? That doesn't seem very desirable. Usually when discussing improvements in IS we think of higher glucose uptake in muscle cells (e.g. via GLUT4) or decreased glucose production in the liver.

So if you really are concerned with your IS, stick to the proven methods: Intermittent fasting, low carb days, Metformin, Cinnamon, Taurine, cardio.
 
Three things:

1) I think you mean 'ameliorate' rather than mediate?

2) When they say the effect on insulin sensitivity (IS) is significant, they probably mean statistically significant. So whether the effect is practically relevant is hard to say without reading the study.

3) Based on this abstract, MT2 increases IS of fat cells rather than muscle cells? That doesn't seem very desirable. Usually when discussing improvements in IS we think of higher glucose uptake in muscle cells (e.g. via GLUT4) or decreased glucose production in the liver.

So if you really are concerned with your IS, stick to the proven methods: Intermittent fasting, low carb days, Metformin, Cinnamon, Taurine, cardio.

No low carb days for me. No international fasting. I’m on a lean bulk.
Metformin made me feel like total shit!
I use taurine Pre and post workout.
I’m using IGF1-LR3 to help insulin sensitivity.
Just looking for more options.
 
No low carb days for me. No international fasting. I’m on a lean bulk.

Metformin made me feel like total shit!

I use taurine Pre and post workout.

I’m using IGF1-LR3 to help insulin sensitivity.

Just looking for more options.



How is the lr3 working.


Sent from my iPhone using Tapatalk
 
How is the lr3 working.


Sent from my iPhone using Tapatalk

I used it 4 days in a row. Now I’m off from IGF-LR3 for 4 days.
I noticed the fullness was insane for the first 2 days then slightly less on day 3, and less day 4. This makes me think at high doses it’s best to use IGF1-LR3?maybe 1 on, 3 off, or 2 on, 5 off. I use MK-677 every night, and HGH/insulin on non-IGF1 Days. I want to always get that crazy muscle fullness from IGF1 so I’ll play with the protocol until i have my body figured out.
 
I used it 4 days in a row. Now I’m off from IGF-LR3 for 4 days.

I noticed the fullness was insane for the first 2 days then slightly less on day 3, and less day 4. This makes me think at high doses it’s best to use IGF1-LR3?maybe 1 on, 3 off, or 2 on, 5 off. I use MK-677 every night, and HGH/insulin on non-IGF1 Days. I want to always get that crazy muscle fullness from IGF1 so I’ll play with the protocol until i have my body figured out.



What dose u running it at


Sent from my iPhone using Tapatalk
 
What dose u running it at


Sent from my iPhone using Tapatalk

100mcg twice a day so far. I think I’ll run it on off days. I find IGF1 tightens me up while Meditrope HGH bloats me heavy. I like the heavy bloat on lifting days for strength. I did IGF1 on the weekend and no hgh/slin. My weight was 215Lbs 2 days ago. I did hgh/slin Monday, Tuesday, and today. I weighed 226Lbs today. I think using IGF1-LR3 on off days will keep me growing/keep my insulin sensitivity up.
 
Last edited:
100mcg twice a day so far. I think I’ll run it on off days. I find IGF1 tightens me up while Meditrope HGH bloats me heavy. I like the heavy bloat on lifting days for strength. I did IGF1 on the weekend and no hgh/slin. My weight was 215Lbs 2 days ago. I did hgh/slin Monday, Tuesday, and today. I weighed 226Lbs today. I think using IGF1-LR3 on off days will keep me growing/keep my insulin sensitivity up.



I’m going to give it a try. I have been fight mine. 10iu Gh 6 days a week. I can keep sensitive. Have to run slin


Sent from my iPhone using Tapatalk
 
Intracerebroventricular injections = in spinal fluid.

Sent from my SM-N920P using Tapatalk
 
I take it with meals John, 600 mg berberine HCL. I'm on the MK-677 train and planning on insulin, but not injecting HGH or insulin now.
 

Forum statistics

Total page views
558,058,924
Threads
135,758
Messages
2,768,694
Members
160,343
Latest member
12cc
NapsGear
HGH Power Store email banner
your-raws
Prowrist straps store banner
infinity
FLASHING-BOTTOM-BANNER-210x131
raws
Savage Labs Store email
Syntherol Site Enhancing Oil Synthol
aqpharma
yourmuscleshop210x131
hulabs
ezgif-com-resize-2-1
MA Research Chem store banner
MA Supps Store Banner
volartek
Keytech banner
musclechem
Godbullraw-bottom-banner
Injection Instructions for beginners
Knight Labs store email banner
3
ashp131
YMS-210x131-V02
Back
Top