I don't see how it works if it doesn't cross the blood-brain barrier. With a bunch of gaba floating around peripherally, but little on the CNS I think you can get some weird effects. I took it and felt weak, tired, and sick after a few days. I take clonazepam, I wonder if there is growth hormone benefit from that, or baclofen, phenibut, gabapentin, etc. If benzos and taking it supplementary increases GH, shouldn't heavy drinking increase it? Then there are the opiods. They have a reputation for increasing GH. Can kratom do that?