I dont even know where to begin. Half these users are trolls which is why I used the term object rather than subject. Someone may have experience issues with high blood pressure that is not even close to the same thing as any increase in blood pressure is pragmatic.
First off i'm shocked you constantly have worries of adrenal insufficiency and yet demonize mineralocorticoids. Suppress mineralocorticoids and you impair glucocorticoids, and then chain of dysfunction continues from there. Profusion is not so simple that it's one size fits all, hypotension is just as problematic if not more than hypertension. Almost nothing in a vacum is the byproduct of high blood pressure; not heart disease, not renal disorder, not vascular disease, etc. On the other hand; poor profusion, lack of lymph or vascular function, poor blood volume, etc etc all have direct mechanism to lower quality of life. I'm FAR healthier both in quality of life and biomarkers with my systolic BP close to 120-140 than at 90-110. Theres not a day that goes by where I dont have a fight with an ER doctor about forcing a patients BP into the shitter, they dont listen, everything gets fucked, wash and repeat.
The only clear cut thing you can say IMO/IME about BP is that if your pulse pressure is abnormal than you have a problem.