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I see posts every day about people complaining about all types of pain from a variety of causes such as joint pain, tendons, strains etc. I am not the type to immediately suggest meds..they should mostly be a last resort but ive seen some xrays for guys on here with severe joint issues and its either pain control or joint replacement so sometimes meds should be discussed.
Many guys take nsaids for the pain and they are certainly a decent option for many however id suggest looking into etoricoxib. Its not FDA approved but then again neither is tren and you guys dont have a problem with that lol. Its used overseas because of the whole vioxx issues from like 2004.
If you recall there was a bunch of nonsense about vioxx in the early 2000's and Merck took it off the market and wouldnt bring it back even after the FDA panel had voted to bring it back with a warning. This is not a thread to get into the full discussion on cox-2 inhibitors and cardiac risk but i personally think that you will find that with any cox-2 inhibition that doesnt have anti platelet activity its just more apparent when you have like 300:1 selectivity like vioxx did. Theere have been numerous studies looking into this and basically it comes down to primarily decrease cox2 induced prostaglandin production in the vessels. Some earlier studies thought it might be due to the 1-2 ratio but i believe its due to decreased cox2 in the vessels which would mean ANYTHING that decreases cox-2 would potentially have a similiar effect ( except ASA due to platelet). So before someone starts saying well what about this that reduced inflammation...well look at the MOA..does it work on cox 2 or upstream from it...then it probably has the potential for similar effects in the vessels although less pronounced if its inhibiting it less. But if its inhibiting it less then its also having less effects on inflammation which is your desired effect.
I see a lot of guys taking nsaids but it may be worth looking into a selective cox-2 inhibitor like etoricoxib as this is a bodybuilding forum. I was in the camp of believing that most of the nsaid negative effects on protein synthesis was due to cox-2 inhibition but ive read quite a few papers over the last few years showing thats its actually cox-1 and not cox-2 that is expressed in muscle building process.
So benefits of selective cox-2 inhib would be GI mucosa protection and less inhibition of protein synthesis in skeletal muscle. Ive seen some studies showing 50% decrease in protein synthesis if taking high dose nsaidsbut then studies looking at just cox2 didnt really show any decrease. You will see get decreased renal blood flow so i dont believe its much different then taking nsaids with respect to kidney function.
For many guys with somewhat chronic pain 30-60mg daily would be like taking 2000mg of advil a day with respect to pain relief ( depending on the studies it varies).
For more acute pain 90-120mg would be like taking 2400+ mg of advil a day but ofcourse without the cox1 inhibition negative effects.
Those above comparisons vary from study to study so just look up etoricoxib efficacy and ibuprofen etc
As with anything that reduces cox2 you get renal mac densa and loop effects and can get some Na retention/edema in a small percent of people like 4% but this is true or any nsaid as well.
I personally use it for a herniated disc in my neck. Works within a few hours and lasts 24 hours. I have had labs while taking it and nothing has changed at a 60mg dose taken for a week and i dont get any sides but everyone is different.
I made this post as i get the question often about antinflammatory meds and what people should use. Ill leave all the natural stuff to other people. My go to meds are for mild issues ( but signfiicant enough to take something) is naproxen, moderate etoricoxib 60mg, severe ( but i know what is causing it so im not just masking something) either toradol 10mg q4-6 hour or etoricoxib 90-120mg. I dont like taking prednisone for joint/musculoskeletal issues.
Please look into the meds before taking them. Please only consider taking them for known issues or for an issue ur 99% sure is inflammatory in etiology but knee pain from arthritis, bursitis, nerve root inflammation, tenosynovitis etc. Dont have like severe abdominal pain and take this.
Celebrex doesnt really seem to work that well in bodybuilders its just not strong enough for our pain in many situations. I was dissapointed that vioxx never came back to the market but most of the world has access to etoricoxib so its worth looking into.
Many guys take nsaids for the pain and they are certainly a decent option for many however id suggest looking into etoricoxib. Its not FDA approved but then again neither is tren and you guys dont have a problem with that lol. Its used overseas because of the whole vioxx issues from like 2004.
If you recall there was a bunch of nonsense about vioxx in the early 2000's and Merck took it off the market and wouldnt bring it back even after the FDA panel had voted to bring it back with a warning. This is not a thread to get into the full discussion on cox-2 inhibitors and cardiac risk but i personally think that you will find that with any cox-2 inhibition that doesnt have anti platelet activity its just more apparent when you have like 300:1 selectivity like vioxx did. Theere have been numerous studies looking into this and basically it comes down to primarily decrease cox2 induced prostaglandin production in the vessels. Some earlier studies thought it might be due to the 1-2 ratio but i believe its due to decreased cox2 in the vessels which would mean ANYTHING that decreases cox-2 would potentially have a similiar effect ( except ASA due to platelet). So before someone starts saying well what about this that reduced inflammation...well look at the MOA..does it work on cox 2 or upstream from it...then it probably has the potential for similar effects in the vessels although less pronounced if its inhibiting it less. But if its inhibiting it less then its also having less effects on inflammation which is your desired effect.
I see a lot of guys taking nsaids but it may be worth looking into a selective cox-2 inhibitor like etoricoxib as this is a bodybuilding forum. I was in the camp of believing that most of the nsaid negative effects on protein synthesis was due to cox-2 inhibition but ive read quite a few papers over the last few years showing thats its actually cox-1 and not cox-2 that is expressed in muscle building process.
So benefits of selective cox-2 inhib would be GI mucosa protection and less inhibition of protein synthesis in skeletal muscle. Ive seen some studies showing 50% decrease in protein synthesis if taking high dose nsaidsbut then studies looking at just cox2 didnt really show any decrease. You will see get decreased renal blood flow so i dont believe its much different then taking nsaids with respect to kidney function.
For many guys with somewhat chronic pain 30-60mg daily would be like taking 2000mg of advil a day with respect to pain relief ( depending on the studies it varies).
For more acute pain 90-120mg would be like taking 2400+ mg of advil a day but ofcourse without the cox1 inhibition negative effects.
Those above comparisons vary from study to study so just look up etoricoxib efficacy and ibuprofen etc
As with anything that reduces cox2 you get renal mac densa and loop effects and can get some Na retention/edema in a small percent of people like 4% but this is true or any nsaid as well.
I personally use it for a herniated disc in my neck. Works within a few hours and lasts 24 hours. I have had labs while taking it and nothing has changed at a 60mg dose taken for a week and i dont get any sides but everyone is different.
I made this post as i get the question often about antinflammatory meds and what people should use. Ill leave all the natural stuff to other people. My go to meds are for mild issues ( but signfiicant enough to take something) is naproxen, moderate etoricoxib 60mg, severe ( but i know what is causing it so im not just masking something) either toradol 10mg q4-6 hour or etoricoxib 90-120mg. I dont like taking prednisone for joint/musculoskeletal issues.
Please look into the meds before taking them. Please only consider taking them for known issues or for an issue ur 99% sure is inflammatory in etiology but knee pain from arthritis, bursitis, nerve root inflammation, tenosynovitis etc. Dont have like severe abdominal pain and take this.
Celebrex doesnt really seem to work that well in bodybuilders its just not strong enough for our pain in many situations. I was dissapointed that vioxx never came back to the market but most of the world has access to etoricoxib so its worth looking into.
