Best thing I did was get the calcium score scan. Father died at 47 from heart disease/diabetes. Out of 12 kids, he and 9 siblings died before age 50. Two made it to 70's.
So bad health on that side is rampant. (Ma's sode has great genes/longevity). Ive been on statins since age 40 (14 years) because of my familial problem. (LDL and Trig's off the charts high). Been training since 1978, and only jumped on TRT when I turned 50 back in 2016. (38 years of natty training). I scored a pretty high 500 on that calcium test which "could" mean severe atherosclerosis. When I went in for much more testing (nuclear stress test, etc) they found I am fine, and its just the plaque that calcified, and didn't rupture. (Statins do their job in familial issues like mine). My ejection fraction is 65% which is near the top I believe. No blockages, etc.
So my usage is newish but I do experiment lightly. My normal cruise is 125 mg a week of Test-Eth. A couple times a year I will bump it to 250 a week and add a minor 10 mg of Var per day. (Like 2 "eight week" mini-blasts (for me at least) if you would). With my age and light usage, I actually feel those "mini-blasts" and gain (minimally) from them. Ill stop that soon and just keep low TRT dose Im sure, but those mini blasts dont seem to upset my bloods, etc. (As I get older, Ill just stick with low dose test/TRT). (My cardiologist is fine with my small usage as he knows I'm health conscious, I monitor every 12 weeks (bloods) and can discuss all blood-work related numbers with him and know a lot, like most of us here who do bloods and understand them).
Not happy about the calcium, but it could be much worse. Its more of arterial stiffening I guess, and I have since upped my cardio big-time, and take some health supps to support heart-health.
A pic of what happens in issues like mine.