Hey guys I have been following these forums for quite some time and I have learned a lot from the information provided here. I recently came across this really interesting article and I was wondering what you guys think about this natural herbal supplement. I wonder if this can be beneficial on TRT by itself Trt + HCG or in combination with some kind of fertility protocol for those who are trying to conceive. I meant to come back and add more to my post its a shame you went ahead and just banned me without any warning, allowing me to elaborate in any way or hearing me out. If I went against the rules i apologize but I felt like this could be beneficial to some of you and be able to help guys who are struggling in this area and I wanted to post this because it may be able to help some people. There's other information out there on this and you could just look it up for yourself I just want to get the information out there so you guys can come to your own conclusions.
"In the present study, we evaluated the protective effect of icariin on Sertoli cell injury and explored the possible mechanism(s)
in vivo and
in vitro. Dietary administration of icariin for 4 months significantly ameliorated the age-related decline in testicular function
by increasing testicular and epididymal weights and indices, sperm count and sperm viability, testicular testosterone and estradiol concentrations, and seminiferous tubule diameters and heights. In addition, icariin protected age-related Sertoli cells from injury as evidenced by an analysis of Sertoli cell number, ultrastructure, and function. Such changes were accompanied by upregulation of ER
α and Nrf2 signaling in Sertoli cells. Parallel
in vitro studies also demonstrated that icariin inhibited untoward effects on the TM4 mouse Sertoli cell line with concomitant upregulation of ER
α and Nrf2 signaling. Conversely, ER
α siRNA reversed icariin-mediated protection of Sertoli cell injury. Our data suggest that icariin effectively ameliorates age-related degeneration of testicular function by alleviating Sertoli cell injury
via the ER
α/Nrf2 signal-transduction pathway. Thus, mitigating Sertoli cell damage
via the ER
α/Nrf2 signaling pathway likely represents a promising strategy for the prevention of age-related testicular dysfunction."
If you want to look at the study for yourselves this is it and there are others out there for those of you who are actually interested in looking at the science. From the information above you can see that there was growth in the areas specifically where the sperm is produced and transported as well as improvements in the sperm itself.
Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a flavonoid from Epimedium, has been reported to exhibit anti-aging e...
www.frontiersin.org