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25mg MK677 bloodwork FAQ = 4iu pharm grade HGH (used 25mg mk677 for 6 months out of the year for 5 years straight with 7 bloodworks)

tregar

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Smont said:
There is no amount of mk that will make it comparable to gh because they don't do the same thing. They have a few things in common but more things that make them completely different.
I've taken 25mg MK66 powder in morning with coffee for 6 months out of the year, for 5 years now, and I've taken at least 7 blood works over the years (cost me nothing as it goes on my pre-loaded $1800 medical card), MK677 is highly effective for 8 months, when it then starts to dip a bit from the peak, it only looses slight effectiveness at that point as it is a derivative of GHRP-6. At that point (6 months, a little bit sooner than 8 months) is when I go off. I will then switch to peptides (remain effective indefinitely, but expensive) at that point for the next 6 months.

1) Smont is correct in that it will not help you loose fat like HGH, BUT it has just as great if not greater nitrogen retention as 4iu of HGH, you can fast for long periods like I do (I eat in an 8 hour window, on a keto diet, and fast from 3pm till 7am next morning with cardio during the fast to maintain my 220lbs at 12% body fat), and never loose any muscle...just keeps piling on week after week). I also notice a 25 to 35% increase in strength over the many months I use it, compared to placebo, or the months I have not used it at all (no mk677, no peptides, nada). The studies on older folks also showed a 25% increase in strength in all leg press exercises in those who used it as well as compared to non-users.

I actually went back on the mk677 at 25mg several days ago, gonna use for at least 6 months (July 2022 till end of January 2023)....will go back on the peptides after a long 6 month mk677 run.

I alternate the two every 6 months so the mk677 stays 100% effective, go on the peptides for 6 months, then back on mk677...mk677 never loses any effectiveness this way. The peptides I use (100mcg mod grf 1-29 + 100mcg ipamorelin) x 3 times a day never loose effectiveness. I take one shot in morning, one before or after workout (before cardio on non workout days) and one shot before bed. Peptides can be used for life and never loose any effectiveness as this combo is NOT a derivative of GHRP-6. MK677 is dirt cheap compared to the peptides (around 120 a month for x 3 times a day for 30 days, and gives me very similar levels to the mk677)...I always save big time money on the 6 months I am on MK677 compared to the peptides.

mase 1 said:
I notice great muscle fullness on mk677. Do you notice a difference with ghrp/ipamorelin in regards to comparing muscle fullness?
Yes, there is muscle fullness on the peptides, but the fullness on mk677 is even greater, like a dianabol feeling, super great nitrogen retention too. Really great mk677 pumps, very full indeed. The mk677 gives me the HGH of 4.0iu, I've done bloodwork on both mk677 and 4iu of pharm grade HGH, both the same.

Benefits of MK677 I've noticed:
1) releases your own natural stored up HGH in your brain that you still make plenty of when you are older, but due to the body programming the body for death as you get older, it does not release these huge stored up amounts anymore...MK677 puts the breaks on somatostatin so that these youthful levels of HGH can be released. Unlike HGH, MK677 is way less expensive, and you never have to worry about your body's natural production of HGH being shut down or diminished for very long periods of time which has been shown to happen if you take HGH daily for year or more straight. Even the brain's natural production of HGH has been shown to NOT HAPPEN if you take HGH during morning hours, studies show the night time HGH pulses are still suppressed.
2) great nootropic effect on the brain = improved mood
3) great sleep with longer time in REM sleep, better muscle building during sleep
4) better energy all day.
5) Skin looks younger due to greater collagen production,
6) recover quicker from injuries and minor cuts
6) increased lubrication of joints in gym due to same collagen increase
7) nails and hair grow very fast. No lethargy at all for me, zero.
8) truly do feel like an 18 year old on it. Best nootropic imho.

I'm on a year round keto diet, so the water retention in the face is very minimal, and goes away completely along with the minor hunger pains after 2 to 3 weeks. Then it's smooth sailing. Mk677 sends my igf-1 from 225 to 370 or so igf-1.

Daily 25mg takes me to the HGH output of a gifted 18 year old.

Update: 2 days after being on 25mg a day mk677, feel great! crystal clear clarity in the brain, zero brain fog, feel great pump all day, increased endurance in gym and cardio on off day, really great mood, mega pumps during workout, great sleep, love the stuff! Will use from June 23, 2022 till end of December 2022 (6 months).
----------------------------------------------
25mg MK677 bloodwork FAQ = 4iu pharm grade HGH (used 25mg mk677 for 6 months out of the year for 5 years straight with 7 bloodworks)

Year 2018:
------------
pic 1) 4-6-2018, baseline igf -1 = 227 ng/ml------------------------------------------baseline [227, high] (age 48, ref is 67 to 205 ng/mL)
pic 2) 4-11-2018, 2 days on 4iu of Chinese pharm grade gh = 380 ng/ml----increase of 153 points
washout period of 2 weeks off HGH
pic 3) 4-25-2018, 2 weeks on mk677 only = 372 ng/ml----------------------------increase of 145 points
pic 4) 9-7-2018, 6 months on mk677 only = 322 ng/ml----------------------------increase of 95 points
pic 5) 11-2-18, 8 months on mk677 only = 304 ng/ml--------------------------------------increase of 75 points

Start of new year 2019:
------------------------
pic 6) 3-18-19, 4 weeks on mk677 only = 327 ng/ml-------------------------------------increase of 100 points, (2-22-19 thru 3-18-19)

Start of new year 2020:
-------------------------
pic 7) 2-3-2020, 2nd baseline igf-1 reading = 229 ng/ml-----------------------------------baseline [229, high] (age 50, ref is 67 to 205 ng/ml)

Notice how using MK677 for many years, did nothing to hurt my normal IGF-1, it read completely normal when I came off it for several weeks.

372 ng/ml igf-1 is equivalent to 4.0 iu pharm grade GH from China, as 95 point raise per each 1iu of hgh for me (2 weeks)
322 ng/ml igf-1 is equivalent to 3.4 iu pharm grade GH from China, as 95 point raise per each 1iu of hgh for me (6 months)
304 ng/ml igf-1 is equivalent of 3.2 iu pharm grade GH from China, as 95 point raise per each 1iu of hgh for me (8 months)
327 ng/ml igf-1 is equivalent of 3.5 iu pharm grade GH from China, as 95 point raise per each 1iu of hgh for me (4 weeks)

So, in conclusion, being on mk677 for 2 weeks is similar to being on 4iu of Chinese pharm grade GH, for me anyhow, as the bloodtest proves it. Being on mk677 for 6 months is similar to being on 3.4iu of Chinese pharm grade GH. The Chinese pharm grade HGH I used was Supertropin (used in China to treat dwarfism).

This is an incredible raise in igf-1 for my current age of 52 as reference is 67-205 for my age group, and the mk677 for 2 weeks brought me beyond the high range for a young adult in their early 20's.

I couldn't be happier, this helps explain the increases in strength at the gym, as well as the fast recovery from workouts. Cardio on off days is a breeze. Not to mention mega pumps in the gym, a feeling of fullness all day in muscles, nootropic effects on brain of improved mood for me, enhanced energy all day, great sleep, zero lethargy for me everyday using it (I'm lucky in that aspect). I've even had rare days of less sleep due to schedule, and I still felt like a million bucks the next day being on mk677 as it gives you such great sleep with pleasant enhanced dreams many nights. As I am on a keto diet year round, there is minimal water retention in the face, both the minimal retention of water in face and hunger pains die down to zero after around 2 weeks on it, then it is smooth sailing.

I've continued to take bloodwork every few months, and this 372 igf-1 then falls to around 325 igf-1 (equivalent to 3.4iu HGH) for the rest of the 8 months, still remaining at 325 by the 7 month, when it starts to fall slightly to 300 around month 8, but I get off after 6 months, as that is how long it remains 100% effective without dipping at all from the peak (6 to 7 months it reamains 100% effective). I've taken blookwork every 1 of the 4 years I have used it....my baseline was at 225 the 2nd year I took it (after being off mk677 for 6 months)...it once again took me to the exact same high levels of 4iu pharm grade HGH year after year, each of the 4 years, remains 100% effective year after year, and your baseline never changes from normal.

--> The reason for the fall from 372 to 325 igf-1 is due to a "feedback loop" the body puts in place after being on mk677 for 3 weeks, in order to keep the levels from raising to high, the body will only maintain it at the HGH of around an 18 year old max.

My only concern is that maybe around 25% of people (like myself) never experience any lethargy on MK67, zero lethargy...however from the reviews I have read the other 75% of people do experience lethargy on it, in which case I would recommend NOT using it, it's just not worth it if it makes you tired. Find something else to use like peptides or HGH then.

MK677 should bring you to the high level of a young adult if you are already at the high end for an older adult.
Older folks (59-225ug/L)
young adult (116-358 ug/L)
pic 1.JPG
pic 2.JPG
pic 3.JPG
pic 4.JPG
pic 5.JPG

pic 6.JPG
pic 7.JPG
 
Books to read on HGH "Grow young with HGH" by Dr. Ronald Klatz (5 stars, excellent) and "Human Growth Hormone, research and clinical practice" (has MK677 studies on dogs) by Roy Smith, Ph.D and Michael Thorner, MD.

I go to waterpark with wife, her sister and teenage daughters once weekly with summer pass (where I used to lifeguard for many years), and a couple of times I've been stopped by groups of teenagers with workout questions, two weeks ago, a group of 4 teenagers stopped me and all said "woooahhh" in unison as they gazed at me and asked me questions....totally freaked me out, another time I was asked to take a pic with a group of girls, not used to attention. I blame the mk677 for helping to add dense muscle along with my normal 200mg testosterone cypionate TRT therapy weekly. You can increase your strength up to 35% in weekly periods beyond what you normally do when using it, and it keeps your joints lubricated just like HGH, welcome relief in the gym, and the mega pumps it gives you are great.

smont said:
Super valuable post!, Thank you for sharing that!!!, From what I seen. The benifits of mk are mostly geared towards building muscle or gaining weight, increased recovery. Not the fat burning, My igf-1 elevations we're also similar.
Thank you kindly smont. I'm glad you also see similar igf-1 elevations.

Reformednerd said:
What are your thoughts on 12.5mg vs 25mg?
Love your screen-name, LOL. Yes, 12.5mg is still highly effective, just checkout this attached study or see pic below: https://en.wikipedia.org/wiki/Ibutamoren (study #9, page 4252)

P.S. I do twice a year bloodwork with my doctor, completely normal bloodwork, liver values fine and best of all NORMAL BLOOD SUGAR, MK677 does not affect your blood sugar like high doses of HGH can.

attached 1: "Stimulation of the Growth Hormone (GH)-Insulin-Like Growth Factor I Axis by daily MK677" by 16 authors.
attached 2: "Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677 on young men"

pic 1: great books
pic 2: GH and IGF-1 increase with mk677 compared to placebo
pic 12.JPG
GH and IGF-1 increase with mk677 compared to placebo.JPG
 

Attachments

  • Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK...pdf
    950.6 KB · Views: 6
P.S. I inject my testosterone cypionate oil with an insulin syringe daily (20mg daily) into my shoulder, just like shaving or brushing teeth, part of the routine, my bloodwork is completely normal, stuff saved my life, literally, feel like a million bucks on it, sleep is great too. My doctor is also a bodybuilder, so that helps. He does all he can to improve your quality of life.

I use a 29 gauge, 1ml, 1/2" insulin syringe to draw the testosterone cypionate oil from the vial, it takes a little longer for the oil to fill, as this is an insulin syringe, but it injects very fast...I will never go back to butt injections, etc. This is painless and easy.
 
I appreciate greatly what you're trying to do, @tregar - but as the old adage says, extraordinary claims require extraordinary evidence.

A few weaknesses in your methods that must be highlighted:

1. adaptation & washout periods: to compare GH response (the increase to serum IGF-I), a constant dose must be applied for 6 weeks given the time-course & half-life of liver somatotrophs secreting IGF-I, after a sufficient washout period (due to decrement in GH response; e.g., this table from [1] shows that by month 6 there is a ~12% decrement and by month 9, ~43%). This decrement in GH response arises due to factors including binding protein dynamics (i.e., GHBPs & IGFBPs) and receptor (and downstream element) desensitization (e.g., phosphorylation of elements within the GHR/JAK/STAT5 pathway)

Decrement-in-serum-IGF-I-rhGH-treatment-Table.ProM.png
2. No indication of potential changes to androgen (e.g., testosterone) administration during your trial: testosterone potently stimulates IGF-I (by in situ aromatization, increases serum GH and IGF-I via augmented GH secretory burst mass); trenbolone the opposite

To really even begin to test the assertion that 4 IU rhGH is equivalent in GH response to 25 mg MK0677, you'd have to align the protocol design more closely with this suggestion:

12 weeks washout from secretagogues & rhGH
constant TRT dose (Testosterone)
6 weeks rhGH 4 IU daily: measure serum IGF-I
12 weeks washout from secretagogues & rhGH
6 weeks MK0677 25 mg daily: measure serum IGF-I

If you really wanted to be comprehensive, you could then employ a cross-over design, sequentially swapping the rhGH for the MK0677:

16 weeks washout from secretagogues & rhGH (still constant TRT dose)
Repeat for MK0677 first & rhGH second

P.S. I own Smith & Thorner: it's a great resource, though biased by post-Rudman exuberance for anti-aging applications.

I will share with you my impression of MK-0677 (Ibutamoren): I generally do view its side effect profile as unfavorable (↑cortisol & prolactin; musculoskeletal pain [myalgia, arthralgia] & edema; ↑insulin resistance; ↑appetite), but note that it is a highly effective sleep- & appetite- promoting agent. I would point you to the clinical trial results showing rather unimpressive FFM increases (and no Δ in strength, abdominal nor visceral fat mass), having to be halted due to congestive heart failure prevalence in treatment group, etc. [2].
_____
References:
[1] Johannsson G, Mårin P, Lönn L, Ottosson M, Stenlöf K, Björntorp P, Sjöström L, Bengtsson BA. Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab. 1997 Mar;82(3):727-34. doi: 10.1210/jcem.82.3.3809.
[2] Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sex Med Rev. 2018 Jan;6(1):45-53. doi: 10.1016/j.sxmr.2017.02.004.
 
I would have to disagree with you Type IIx on the cortisol, all studies show there is no cortisol release with MK677, zero. I do not experience any cortisol like side effects either, no waking up early, stress, etc.
Why are my claims so extraordinary? my blood work shows I am reaching the HGH of a gifted 18 year old, and I'm 52 years old. Real world life use of it results in effects I love, does not get any better than that, thanks for your comments! I will continue to use it for the rest of my life, love it!

pic 13.JPG
 
I would have to disagree with you Type IIx on the cortisol, all studies show there is no cortisol release with MK677, zero. I do not experience any cortisol like side effects either, no waking up early, stress, etc.
Why are my claims so extraordinary? my blood work shows I am reaching the HGH of a gifted 18 year old, and I'm 52 years old. Real world life use of it results in effects I love, does not get any better than that, thanks for your comments! I will continue to use it for the rest of my life, love it!

View attachment 159723
See [2] cites 48 & 56 for the increase to cortisol by MK-0677. I consider the claim extraordinary because MK-0677 is regarded as a secretagogue that possesses mostly the negative side effects of GH treatment without a substantial (not to be confused with significant) concomitant rise in serum IGF-I versus rhGH. I feel as though you just read my post, made a snap judgment, and didn't really care to read it.
 
Type-IIx, according to study attached (page 2781) cortisol is virtually identical to placebo, notice 219 vs 216. I can cite 2 other studies that state the same.

ReformedNerd said:
If cycled for 6 months do you need 6 months off or how much time off is required?
If you run MK677 for 6 months, then be sure to take off 5 months, then you can use it again, that's the way I've used it for years. If you use it for 8 months, then be sure to take off 5 months as well, then you can start it again, that way always remains 100% effective when you go back on it. Find something else to use on the 5 months off, like peptides or HGH.

On the 5 to 6 months off MK677, I use a blend of 5mg mod grf 1-29 (cjc-1295 no DAC) + 5mg ipamorelin (100 mcg of each) x 3 times a day, 1st thing in morning, pre-workout or pre-cardio on non workout days, and pre-bed.

This is my bloodwork after using the blend for 2 weeks, as you can see it took me to the IGF-1 range of better than most 18 year olds. I had the blood drawn at the local lab core approximately 1 hour after my first injection into skin pinch of my abdomen, I inject right under the skin subcutaneously x 3 times a day. Luckily, there was not much of a line of people in the morning, only 2 people in front of me. I go super early.

5mg mod grf 1-29 + 5mg ipamorelin
5000mcg (5mg) per vial
add 2ml bac water in vial
4iu (2 small tics, as each tic = 2iu) on a standard 100iu (1ml) insulin pin gives 100mcg of each
4iu (4 small tics, as each tic = 1iu) on a 3/10 syrige insulin pin gives 100mcg of each
pic 14.JPG
pic 15.JPG pic 16.JPG
 

Attachments

  • Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK...pdf
    950.6 KB · Views: 1
Type-IIx, according to study attached (page 2781) cortisol is virtually identical to placebo, notice 219 vs 216. I can cite 2 other studies that state the same.

ReformedNerd said:

If you run MK677 for 6 months, then be sure to take off 5 months, then you can use it again, that's the way I've used it for years. If you use it for 8 months, then be sure to take off 5 months as well, then you can start it again, that way always remains 100% effective when you go back on it. Find something else to use on the 5 months off, like peptides or HGH.

On the 5 to 6 months off MK677, I use a blend of 5mg mod grf 1-29 (cjc-1295 no DAC) + 5mg ipamorelin (100 mcg of each) x 3 times a day, 1st thing in morning, pre-workout or pre-cardio on non workout days, and pre-bed.

This is my bloodwork after using the blend for 2 weeks, as you can see it took me to the IGF-1 range of better than most 18 year olds. I had the blood drawn at the local lab core approximately 1 hour after my first injection into skin pinch of my abdomen, I inject right under the skin subcutaneously x 3 times a day. Luckily, there was not much of a line of people in the morning, only 2 people in front of me. I go super early.

5mg mod grf 1-29 + 5mg ipamorelin
5000mcg (5mg) per vial
add 2ml bac water in vial
4iu (2 small tics, as each tic = 2iu) on a standard 100iu (1ml) insulin pin gives 100mcg of each
4iu (4 small tics, as each tic = 1iu) on a 3/10 syrige insulin pin gives 100mcg of each
View attachment 159725
View attachment 159726View attachment 159727
It's excellent that you've had good successes with the secretagogues in line with your objectives: they clearly hold value. I am glad that you are finding benefits!

I will agree that perhaps the effects on cortisol by MK0677 are insubstantial and if anything, unclear (e.g., there seems to be an increased 24-h accretion of cortisol & perhaps a dose-dependent increase to mean plasma total cortisol); but the significance of this is subject to disagreement. That's fine.

The only claim that I take exception to is that of the topic/subject of this thread: as performed, it cannot be stated that 4 IU rhGH is equivalent to 25 mg MK0677 in the increase to serum IGF-I.
 
So all you did bloodwork for was igf-1 levels? Thats not enough. You gotta keep an eye on insulin resistance and sensitivity, blood glucose levels, cortisol, prolactine, and so on and so forth. It's good to see igf-1 levels over 5 years but what about every other aspect (good and bad) that comes with taking mk-677?
 
So all you did bloodwork for was igf-1 levels? Thats not enough. You gotta keep an eye on insulin resistance and sensitivity, blood glucose levels, cortisol, prolactine, and so on and so forth. It's good to see igf-1 levels over 5 years but what about every other aspect (good and bad) that comes with taking mk-677?
Heh, I don't disagree if we're to really gain a comprehensive understanding for the net effects of MK0677.

Still, I wouldn't want to dismiss the significance of these results when most guys merely report "sick pumps; fullness; great sleep/recovery; GTG" and that's viewed as sufficient evidence of benefits. It's prohibitively expensive to self-monitor all of these parameters (and IGF-I is the primary outcome we should be concerned with).
 
Sept 2018 labs (measured during 7month of taking mk677 daily) reveal labs to be completely normal for insulin sensitivity, and this was without taking +R-ALA or berberine. I have since added +R-ALA supplement the previous year & this year however (one before at least 2 of 3 meals). +R-ALA is also great post-workout, studies show the ability of +R-ALA to enhance insulin action on glucose metabolism in skeletal muscle, esp in those with some form of developed insulin resistance. As mentioned before, I'm on a year round keto diet, and have been for many years, and also fast from 3pm to 7am next morning, eat in an 8 hour window and run or do cardio during the fast (after 3pm).
zzzzz normal blood glucose.JPG
 
So you are doing keto and fast for more than 12 hours, yet you have an hba1c of 5,1 and fasting glucose is also still high if you were giving that blood in the morning after fasting for half a day and night.

Seriously, this might work for you bc you do a lot of fasting and also keto year around, but I promise you everyone eating in a normal way with carbs will see his insulin levels, sensitivity, his resistance spike. And that comes with problems.
 
So you are doing keto and fast for more than 12 hours, yet you have an hba1c of 5,1 and fasting glucose is also still high if you were giving that blood in the morning after fasting for half a day and night.

Seriously, this might work for you bc you do a lot of fasting and also keto year around, but I promise you everyone eating in a normal way with carbs will see his insulin levels, sensitivity, his resistance spike. And that comes with problems.
He has a point @tregar - if a guy who is > 15% b.f. and/or on a moderate (or high) CHO diet were to use MK0677, it sure seems rational for him to expect some hyperglycemic effects if not progression towards prediabetes - considering you are keto (!) - judging by these results.
 
So you are doing keto and fast for more than 12 hours, yet you have an hba1c of 5,1 and fasting glucose is also still high if you were giving that blood in the morning after fasting for half a day and night.

Seriously, this might work for you bc you do a lot of fasting and also keto year around, but I promise you everyone eating in a normal way with carbs will see his insulin levels, sensitivity, his resistance spike. And that comes with problems.
Promises promises...Provide some evidence rather than denigrate this stack of positive evidence he has provided. Otherwise you are just a bullshiter.
 
Promises promises...Provide some evidence rather than denigrate this stack of positive evidence he has provided. Otherwise you are just a bullshiter.
Have you ever seen someone having such a high fasting glucose (around 90) while doing keto and also after fasting for more than 15 hours? No you have not, neither did I. His method works for him and that's great, but it will not work for other's. Mk-677 def screws up quite a few things and he managed to balance them out in a somehow more or less healthy way, but that is about it.
 
Have you ever seen someone having such a high fasting glucose (around 90) while doing keto and also after fasting for more than 15 hours? No you have not, neither did I. His method works for him and that's great, but it will not work for other's. Mk-677 def screws up quite a few things and he managed to balance them out in a somehow more or less healthy way, but that is about it.
Well yes I have. I worked in clinical labs from 1988 to 1993. That is normal range. Gluconeogenesis will produce glucose from glucogenic amino acids and blood glucose will be in normal range. 90 is in the normal range. Now, I would not use MK677 for 5 years 6 monthws at a clip like OP has either but it seems to work pretty well for him. But hey, we are all risk takers or else we would not be on a PED board putting some very gray area shit in our bodies. OP at least has done the diligence to track blood better than probably 95% of people doing this stuff. His information is gold really.
 
Looking at everything once more, it would appear that the manner in which tregar is using MK0677 demonstrates no effect (perhaps at this 25 mg dose in a healthy, active subject it is not a significant effect) to induce insulin resistance (n=1). Normal is normal, after all.

I looked into long-term adaptations to ketogenic dieting, and it's actually the opposite of what I believed with respect to blood glucose concentrations (I believed that keto must lower blood glucose in response to the brain's increased use of ketones). Basically, pickapeck is correct that in ketosis, gluconeogenesis provides for normal blood glucose concentrations. Ketosis occurs by increased β oxidation, such that the liver is unable to use all available FAs as energy substrates (already this hints to us that there is a likely trend towards insulin resistance in ketosis - there is mechanistic evidence of long-term adaptations to keto-style diets reducing GLUT-4 & IRS protein content in muscle as well). Indeed, ketones basically serve as an alternate brain energy source; ketones are not insulin sensitizing, rather they tend to spare protein (fend off proteolysis) & are an inefficient energy source, such that theoretically you might see some minor fat loss per kcal vs. non-keto.

All tregar has done is provided good evidence of MK0677 benefits (and normal blood glucose despite theoretical reduced insulin sensitivity by keto-style diets). While I merely disputed the equivalency between 4 IU rhGH vs. 25 mg MK0677 (with respect to the increase to serum IGF-I), I saw that he corrected that in a subsequent post which was more than enough for me.
 
MK677 increases time in stage IV and REM sleep, greatly enhanced sleep, see 1st study "Effects of a 7 day treatment on young men...."

According to attached study #2 (too large to post), you should take it in the morning for the greatest GH release, see pics.
pic 17.JPG
 

Attachments

  • pic 17.JPG
    pic 17.JPG
    43.4 KB · Views: 1
  • Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK...pdf
    950.6 KB · Views: 0

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