Pharmacokinetic Data for Testosterone Propionate vs. Testosterone Suspension
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Testosterone propionate
View attachment 160464
[13]
Observations:
- 25 mg i.m. only minimally suppressive of endogenous T
- rapid dissolution of (de-esterified) radiolabeled T from the propionate ester
View attachment 160463
[13]
- mostly in agreement (Subject 1 particularly) with Nieschlag & Behre:View attachment 160462
(t1/2: 0.8 day [19.2 hr] & MRT: 1.5 days [36 hr])
Testosterone suspension
Biphasic delivery profile:
View attachment 160460[15]
0.15 mg/kg aqueous testosterone suspension (75 mg/mL) in horses; mean weight 534.1 kg (i.e., mean dose 80 mg):
[15]
View attachment 160459
[15]
From Kerr, Chapter Twelve:
TNE bloodwork: [withheld; off-site reference]
__________
References:
[13] Shinohara, Y., Fujioka, M., & Baba, S. (1988). Pharmacokinetic studies of testosterone propionate using gas chromatography/mass spectrometry/selected Ion monitoring. Biological Mass Spectrometry, 16(1-12), 241–244. doi:10.1002/bms.1200160144
[14] SEVRINGHAUS, E. L., & SIKKEMA, S. (1946). THERAPY WITH AQUEOUS SUSPENSIONS OF TESTOSTERONE. The Journal of Clinical Endocrinology & Metabolism, 6(6), 415–419. doi:10.1210/jcem-6-6-415
[15] MOELLER, B. C., SAMS, R. A., GUINJAB-CAGMAT, J., SZABO, N. J., COLAHAN, P., & STANLEY, S. D. (2011). An interlaboratory study of the pharmacokinetics of testosterone following intramuscular administration to Thoroughbred horses. Journal of Veterinary Pharmacology and Therapeutics, 34(6), 588–593. doi:10.1111/j.1365-2885.2011.01277.x