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For those of you out there interested in using melanotan I have recently found some interesting information involving research done on afamelanotide (melanotan 1). Melanotan 1 is a prescription medication used to treat rare skin disorders but recently they have been conducting studies to assess its capabilities in DNA repair and as a treatment following stroke. Below you will find a lot of information involving a ton of different effects attributed to this peptide. Many of them very beneficial for bodybuilders: lowering of blood pressure, protection against atherosclerosis, fights inflammation, strengthens the blood brain barrier, and improves cognitive function.
Melanotan 1 and DNA repair:
In the image below we see the process that damages DNA on the left and the DNA repair on the right.
Another study commenting on a-MSH analogues and melanoma: (link to study https://onlinelibrary.wiley.com/doi/full/10.1111/bjd.13598)
"Recent review articles on molecular signalling pathways in melanoma development no longer indicate that the αMSH/melanocortin-1 receptor (MC1R) intracellular signalling pathway has melanoma-inducing or promoting activities. In contrast, low activity MC1R variants are associated with increased risk of sporadic melanoma which indicates that decreased and not increased MC1R signalling is associated with melanoma development. Moreover, melanocyte stem cells and therefore most likely also melanoma stem cells, the latter being crucial for melanoma promotion, do not express MC1R and therefore do not react to αMSH analogues."
Some interesting articles from Clinuvel, the company behind afamelanotide:
www.clinuvel.com
www.clinuvel.com
www.clinuvel.com
Melanotan 1 for Arterial Ischemic Stroke:
www.clinuvel.com
Afamelanotide, a melanocortin drug, is shown to provide anti-oxidative, anti-oncotic and vaso-active effects. Stroke was selected as the first clinical target for PRÉNUMBRA® Instant, enabling physicians to personalize treatment in acute care. CLINUVEL’s recent stroke study (CUV801) showed afamelanotide to be well tolerated in a standard dose, with the majority of patients experiencing a strong functional recovery.
Melanotan 1 vs. Melanotan 2:
If you use Melanotan 2 don't take offense to anything I'm about to say, this is just my personal opinion from the information I have gathered. Many people use Melanotan 2 over Melanotan 1 thinking it is the successor and a better product. The reality is Melanotan 2 has much, much less research and effects the body in a much more widespread way. This isn't to say it is not safe, I personally don't know just like everyone else because the research just isn't there. Many like it for its effects on libido but don't realize behind the scenes it is doing much more, it crosses the blood brain barrier which is a little bit sketchy considering we don't know exactly what it is doing. It also can effect the eyes, even changing the color of your eyes. Again, who knows what else it could be doing inside of your body. For reasons like this I choose Melanotan-1 all day, tons of research and it has a more targeted effect. That being said the tan takes longer to set in and you may not be able to get quite as dark as on Melanotan 2.
Another massive benefit of Melanotan 1 is that people often don't have nearly as many side effects compared to Melanotan 2, nausea is still common but not nearly as bad in comparison.
More information continued in the next comment: Hit the post character limit.
Melanotan 1 and DNA repair:
In the image below we see the process that damages DNA on the left and the DNA repair on the right.
Another study commenting on a-MSH analogues and melanoma: (link to study https://onlinelibrary.wiley.com/doi/full/10.1111/bjd.13598)
"Recent review articles on molecular signalling pathways in melanoma development no longer indicate that the αMSH/melanocortin-1 receptor (MC1R) intracellular signalling pathway has melanoma-inducing or promoting activities. In contrast, low activity MC1R variants are associated with increased risk of sporadic melanoma which indicates that decreased and not increased MC1R signalling is associated with melanoma development. Moreover, melanocyte stem cells and therefore most likely also melanoma stem cells, the latter being crucial for melanoma promotion, do not express MC1R and therefore do not react to αMSH analogues."
Some interesting articles from Clinuvel, the company behind afamelanotide:
DNA Repair - CLINUVEL
www.clinuvel.com
SCIENTIFIC COMMUNIQUÉ IX - CLINUVEL
Beyond Pigment, the Melanocortin 1 Receptor (MC1R) in DNA Repair March 2021 Abstract SCIENTIFIC COMMUNIQUÉ VIII explores how our skin cells instigate DNA damage responses (DDRs) following the induction of DNA damage by ultraviolet (UV) and high energy visible (HEV) light. We are exposed to...
www.clinuvel.com
SCIENTIFIC COMMUNIQUÉ VIII - CLINUVEL
DNA Repair Mechanisms December 2020 Introduction DNA is the repository of genetic information, often referred to as the biological blueprint for all living cells. Collectively the human genome is composed of 30,000 genes, with each gene carrying the information needed to produce, or synthesise...
www.clinuvel.com
Melanotan 1 for Arterial Ischemic Stroke:
PRÉNUMBRA® for stroke - CLINUVEL
Melbourne, Australia, 28 July 2022 ASX: XETRA-DAX: Level 1 ADR: CUV UR9 CLVLY Watch CLINUVEL’s Head of Clinical Operations, Dr Pilar Bilbao, discuss the Company’s stroke program and the upcoming CUV803 study here. EXECUTIVE SUMMARY PRÉNUMBRA® Instant to be evaluated in arterial ischaemic stroke...
www.clinuvel.com
Afamelanotide, a melanocortin drug, is shown to provide anti-oxidative, anti-oncotic and vaso-active effects. Stroke was selected as the first clinical target for PRÉNUMBRA® Instant, enabling physicians to personalize treatment in acute care. CLINUVEL’s recent stroke study (CUV801) showed afamelanotide to be well tolerated in a standard dose, with the majority of patients experiencing a strong functional recovery.
Afamelanotide in Stroke:
Scientific progress has demonstrated melanocortins, including afamelanotide, provide a positive effect on the central nervous system (CNS). Afamelanotide is known to offer neuroprotection and act as a potent anti-oxidative hormone. The drug possesses further therapeutic benefits, activating vessels, reducing fluid formation, protecting critical nerve and brain tissue, and restoring the blood brain barrier (BBB: a critical defence mechanism protecting the brain). The drug therapy is thought to improve blood flow and increase the delivery of oxygen and nutrients to deprived brain tissue.Melanotan 1 vs. Melanotan 2:
If you use Melanotan 2 don't take offense to anything I'm about to say, this is just my personal opinion from the information I have gathered. Many people use Melanotan 2 over Melanotan 1 thinking it is the successor and a better product. The reality is Melanotan 2 has much, much less research and effects the body in a much more widespread way. This isn't to say it is not safe, I personally don't know just like everyone else because the research just isn't there. Many like it for its effects on libido but don't realize behind the scenes it is doing much more, it crosses the blood brain barrier which is a little bit sketchy considering we don't know exactly what it is doing. It also can effect the eyes, even changing the color of your eyes. Again, who knows what else it could be doing inside of your body. For reasons like this I choose Melanotan-1 all day, tons of research and it has a more targeted effect. That being said the tan takes longer to set in and you may not be able to get quite as dark as on Melanotan 2.
Another massive benefit of Melanotan 1 is that people often don't have nearly as many side effects compared to Melanotan 2, nausea is still common but not nearly as bad in comparison.
More information continued in the next comment: Hit the post character limit.
