Here is how I started on prami. I went to my doctor and told her I had RLS and wanted to try prami for it. She put me on .125mg/day before bed to start. After two weeks I upped the dose to .25mg/day and after two more weeks I went to .5mg/week.
Even at .125mg/day, the effect is strong at first, I would not start higher than this. Once you get used to the dose, the sides are pretty much nonexistent.
.5mg/day did a great job of controlling sides from 350mg/week of tren hex, I actually have pretty much zero sides from the long acting tren with the prami included.
After about a year on prami, I tapered off in the exact same way, and had no issue getting off it.
It was posts by Macro that got me interested in prami, and I looked closely at the different options...