I think it was one of Jewett's recent videos - I could be wrong - that talked about protein and enhanced vs. natural.
One of the key reasons bodybuilders need so much protein is to maintain a positive nitrogen balance.
However, when on AAS, this anabolic state is largely enforced through their direct effects on muscle protein synthesis and suppression of protein breakdown.
That said, getting enough protein remains necessary to supply the amino acid substrates required for tissue accretion, even if the threshold for achieving positive nitrogen balance is reduced.
So in theory we need less protein than when using gear, not more. In theory.
I think once you are in positive nitrogen balance and have enough aminos in the blood total calories becomes the growth limiter. Once enough building blocks are available the body will evaluate total energy requirements of growing larger, and it won't allow it if there aren't enough calories. In other words, if total calories are insufficient relative to growth demands, the capacity for further hypertrophy is constrained. Conversely, when energy intake is adequate or in surplus, the energetic cost of synthesizing and maintaining additional tissue is more likely to be met. In some case extra protein may be filling the role of extra energy more than anything else, once needs are met.
I agree 100% with this, and these are my conclusions after years of experience. I even talk about it in the YouTube video I posted here.
For years I was a real high-protein guy. I was eating around 450–500g of protein per day, counting only “pure” sources. So in reality it was more like 500–600g per day, and sometimes even more. Maybe 700g on some days. I’m not joking.
Yes, I got results, but the side effects were even worse, and it actually stopped my progress. My digestion was terrible, I was bloated all the time, so training was not how it should be. Doing legs or back with a bloated stomach was a nightmare. I couldn’t train with full intensity. My sleep was also bad. I had sleep apnea, so recovery was not good.
On top of that, I was putting a huge load on my kidneys and liver because of urea and because my body had to process massive amounts of amino acids and calories every day. Only after years I understood it.
I also used to think that since steroids and hormones increase protein synthesis, we can eat more protein and use more. But that’s not really true. In many cases it’s the opposite: we can eat less protein, because we use it more efficiently.
So for us, 50g of protein in a meal is not the same as 50g for a natural guy, because our nitrogen balance is high all the time. And once you already have enough protein, eating more does nothing except stress the body: more load on digestion, kidneys, liver, more bloating, worse sleep. And that can actually hurt growth and health.
And if your health is getting worse, you will not grow optimally. At some point, what drives growth is calories (especially carbs) and training quality, not extreme protein.
Today I prefer to eat a bit less protein rather than too much. Most people do the opposite, but this is what works for me and my clients.