8-hour time-restricted eating linked to a 91% higher risk of cardiovascular death.

[buck]

I am 5"5" these days. Was obviously a short baby and weighed almost 9 pounds. So i was a fat baby. Spent most of my 20's unemployed as i had no talents other then breathing and being able to move my hands. Took charge of my life lost the fat, stepped on stages. Got some education. Retired in my 50's with a very low 6 figure lifestyle. Society and noise were not my issues. I was. And only i can change me. We are all a compilations of our choices. I don't blame others for me choosing to asking my x wife for a date or to marry me. It is all on me.

 

[qbkilla]

You diminish concepts you dont understand a lot. Some people think about food more often than others. That is what people are referring to when they say food noise. Not everyone has the same amount discipline that's not something that should be surprising to hear.

Why not just call a spade a spade? A lack of self control doesn't need to be called "food noise" so people's feelings don't get hurt. Imo thats what's wrong with society, we make up these stupid politically correct words and make excuses for everyone.

 

[PissedPajamas]

You diminish concepts you dont understand a lot. Some people think about food more often than others. That is what people are referring to when they say food noise. Not everyone has the same amount discipline that's not something that should be surprising to hear.

Putting something in your mouth that you shouldn’t when you’re trying to lose weight is just a shitty use of free will. Literally just don’t do it

 

[southernmucle214]

Why not just call a spade a spade? A lack of self control doesn't need to be called "food noise" so people's feelings don't get hurt. Imo thats what's wrong with society, we make up these stupid politically correct words and make excuses for everyone.

It has nothing to do with hutt feelings or being politically correct. It's just a way to simplify the explanation that some people have a much higher appetite than others and think about food more than others. It's not a foreign concept.

 

[southernmucle214]

Putting something in your mouth that you shouldn’t when you’re trying to lose weight is just a shitty use of free will. Literally just don’t do it

That would be ideal, yes. But most people are not robots and there's a human component to it. Just like everyone has done something they were not supposed to and knew it as they were doing it.

 

[qbkilla]

It has nothing to do with hutt feelings or being politically correct. It's just a way to simplify the explanation that some people have a much higher appetite than others and think about food more than others. It's not a foreign concept.

It has 100% to do with feelings. Any person who wants to lose weight has a formula to do it...its simple. Calling people's desire to indulge in junk food "food noise" doesn't change anything. Everyone on earth has the ability to eat as much or as little as they choose.

"Money noise " doesn't make people rob banks. "Sex noise" doesn't make people rape. "Beer noise" doesn't make people alcoholics.

 

[massephase]

Putting something in your mouth that you shouldn’t when you’re trying to lose weight is just a shitty use of free will. Literally just don’t do it

I think it depends on motivation. If you really WANT to do something, I.e. there is a strong motivation to do it (lose weight) then you will not need much willpower. Willpower is a very limited resource. If you don’t want to do something enough and make yourself do it anyway, it will not be successful for long.
This is my response to people saying xyz is easy — it’s easy for them because they have strong motivation because they enjoy it, or for some other psychological reason.

People keep telling me they are amazed at my „discipline“ for training so much and eating according to plan but, aside from the times in a deep deficit or maybe for cardio here and there, I’m just doing what I enjoy doing. I am actually very undisciplined/ lazy with everything I don’t enjoy.

 

[specter]

Putting something in your mouth that you shouldn’t when you’re trying to lose weight is just a shitty use of free will. Literally just don’t do it

So its that easy ? then why arent all gear heads walkin around lookin like Arnold, when things involving the mind and the body is "that easy" ? could it be that there is more to it then "just dont do it" ?

 

[Dog-Slime]

The causation vs correlation example:

They say melatonin increases heart attack risk.

Why would a strong anti-oxidant naturally produced by the body be bad? ITS NOT!

Why do people take melatonin? - To improve sleep

Does poor sleep increase heart attack risk? YES

What causes melatonin users to have an increased risk of heart attacks? The lack of quality sleep!

 

[Fleezy]

i had a boss who was about as wide as he was tall


he would fast throughout the day, but somehow didn't manage to lose a single pound... over the course of several months.


something tells me he was gorging himself before bed each night - sending his blood pressure through the roof, sleep apnea, etc..


so yeah.. he's on reta now, and doing much better.

 

[Stewie]

The causation vs correlation example:

They say melatonin increases heart attack risk.

Why would a strong anti-oxidant naturally produced by the body be bad? ITS NOT!

Why do people take melatonin? - To improve sleep

Does poor sleep increase heart attack risk? YES

What causes melatonin users to have an increased risk of heart attacks? The lack of quality sleep!

Very much so, and then some. Beyond the fulfillment of acting as a potent antioxidant, it also modulates actions of molecular chaperones (different heat shock proteins) that helps a particularly organelle, the endoplasmic reticulum with proper protein folding. Misfolded proteins clumping together is detrimental to cell survival. Essentially in this situation, it's facilitating as a proteostasis regulator.

 

[specter]

Very much so, and then some. Beyond the fulfillment of acting as a potent antioxidant, it also modulates actions of molecular chaperones (different heat shock proteins) that helps a particularly organelle, the endoplasmic reticulum with proper protein folding. Misfolded proteins clumping together is detrimental to cell survival. Essentially in this situation, it's facilitating as a proteostasis regulator.

Kinda like Praeons diseases ? (dont murder me on the spelling)

 

[Stewie]

Kinda like Praeons diseases ? (dont murder me on the spelling)

Yes. A few years ago I had a co-worker die from sporadic creutzfeldt-jakob disease, which is a form of prions. He passed within a few months of his diagnosis.

 

[specter]

Yes. A few years ago I had a co-worker die from sporadic creutzfeldt-jakob disease, which is a form of prions. He passed within a few months of his diagnosis.

Fuckin hell, my uncle is currently experiencing what we think is somekind of prion disease, his brain is showing signs of "turbo" dementia, he is only 57 and in the last 2-3 years his brain has gone to all mosh, but he was living in another country so we didnt know it, we just got him home a month ago and he is in a bad way, last monday he was hit with 4 blood clots.

 

[Stewie]

Fuckin hell, my uncle is currently experiencing what we think is somekind of prion disease, his brain is showing signs of "turbo" dementia, he is only 57 and in the last 2-3 years his brain has gone to all mosh, but he was living in another country so we didnt know it, we just got him home a month ago and he is in a bad way, last monday he was hit with 4 blood clots.

I'm sorry to here that. Jeff my coworker was 61 at the time of his diagnosis. Beginning stages are just like your uncle – rapid dementia.

My thoughts are with you and your family!

 

[buck]

The causation vs correlation example:

They say melatonin increases heart attack risk.

Why would a strong anti-oxidant naturally produced by the body be bad? ITS NOT!

Why do people take melatonin? - To improve sleep

Does poor sleep increase heart attack risk? YES

What causes melatonin users to have an increased risk of heart attacks? The lack of quality sleep!

As it seems many/most people that take melatonin are often taking 5-20+x what the body produces at it's peak when people are young. That could be part of the cause, if it is actually causng heart issues.
I have never known of a hormone that when taken at high doses long term that tended to be good for life expectancy.
I first started taking melatonin some in the early 90's. But have used it regularly for 20 years. As the years go by i use lower and lower doses. Many people try to use it as a sleeping pill and i find it does not work that way. Seems it is like most supplements it only has a benefit up to a certain point and at that point more is not better.

 

[Stewie]

I'm sorry to here that. Jeff my coworker was 61 at the time of his diagnosis. Beginning stages are just like your uncle – rapid dementia.

My thoughts are with you and your family!

Eff'n dumbass— typo- hear.

 

[Stewie]

Lets put this in perspective before jumping to factually incorrect conclusions.

Highest Dose population: The maximum dose administered was 200 mg daily. The range used in this particular study was 40 mg to 200 mg, with a mean dose of 72.7 mg.

Duration ranged from 1 year to more than 10 years:

1 to 3 years: 33 patients.
4 to 6 years: 17 patients.
6 to 10 years: 17 patients.
More than 10 years: 11 patients.

Rethinking Melatonin Dosing: Safety and Efficacy at Higher-than-Usual Levels in Aged Patients with Sleep Disturbances and Comorbidities​

2025 Sep 25;15(10):1040. doi

Results obtained in this observational, analytical, and mixed design study support the conclusion that melatonin in high doses and for a relatively long period of time is associated with improvement in hypertension, ischemic heart disease and diabetes mellitus in aged individuals, although casualty cannot be inferred. Melatonin diminishes progressively with aging and is especially reduced in numerous chronic, age-related non-communicable diseases [13,14]. In humans, beyond its role in regulating circadian rhythms, melatonin demonstrates multifaceted protective functions in cardiovascular disease, involving antioxidant activity, modulation of inflammation, and epigenetic control [12].

This study demonstrates that long-term administration of high-dose melatonin (40–200 mg/day) in older adults with sleep disorders is well tolerated and suggests that it is associated with improvements in arterial hypertension, ischemic heart disease, and diabetes mellitus, alongside favorable modulation of alkaline phosphatase levels without other laboratory alterations. Long-term clinical studies evaluating the safety of high-dose melatonin in elderly patients remain scarce. While our study provides long-term data supporting the safety of high-dose melatonin in elderly patients, further studies are needed to fully establish its long-term risks. The observed improvement in the studied conditions should be interpreted as correlations rather than proof of a protective effect, although they are consistent with the cytoprotective potential of supraphysiological melatonin dosing for improving cardiovascular and metabolic health in the elderly. Future prospective, long-term, randomized trials are warranted to confirm safety and efficacy as well as to define optimal dosing strategies.

Rethinking Melatonin Dosing: Safety and Efficacy at Higher-than-Usual Levels in Aged Patients with Sleep Disturbances and Comorbidities - PMC

Background. Although melatonin is widely used in Sleep Medicine for its chronobiological action, its potent antioxidant and mitochondrial regulatory effects, as well as its immunomodulatory and anti-inflammatory functions, make it of interest as a ...

pmc.ncbi.nlm.nih.gov

 

[Siggy]

Fuckin hell, my uncle is currently experiencing what we think is somekind of prion disease, his brain is showing signs of "turbo" dementia, he is only 57 and in the last 2-3 years his brain has gone to all mosh, but he was living in another country so we didnt know it, we just got him home a month ago and he is in a bad way, last monday he was hit with 4 blood clots.

Thats so shitty.

 

[specter]

Thats so shitty.

Its fuckin scary, my uncle was always a "high speed guy" always workin big projects, helpin several big european companies expand and improve, now there is just nobody home, he just keeps repeating the same stuff, he cant even tell the date, he called my dad on 3 marts and thought it was Feb 25 and he needed help to go to the hospital because of an appointment they already had attended. Dude is just not there anymore.