A new look at dieting "gene activation"

[Biggerp73]

Yes, high insulin levels can blunt the effects of growth hormone (GH). Insulin and GH have complex, often opposing interactions in metabolic regulation. Elevated insulin levels, such as in hyperinsulinemia or insulin resistance, can interfere with GH signaling and its downstream effects, particularly on fat metabolism and insulin-like growth factor-1 (IGF-1) production. Here’s a concise breakdown:GH Signaling Inhibition: High insulin can suppress GH receptor expression and impair GH-induced JAK2-STAT5 signaling in the liver, reducing IGF-1 production, which mediates many of GH’s anabolic effects.Lipolysis Suppression: GH promotes fat breakdown (lipolysis), but insulin is a potent inhibitor of lipolysis. High insulin levels can override GH’s fat-mobilizing effects, limiting its ability to reduce fat mass.Metabolic Crosstalk: Chronic hyperinsulinemia, as seen in conditions like obesity or type 2 diabetes, can disrupt GH’s role in protein synthesis and glucose metabolism, further blunting its efficacy.

Natural fluctuations in hormones are not significant enough to produce noticeable differences

Stop thinking in terms of mechanisms

The empirical data is conclusive

 

[SSFITNESS]

I can’t even begin to count the number of threads and posts here regarding t4 and GH usage. It’s definitely worth a search.

Ill have to check it out it just seemed like a less aggressive path, like taking mk677 instead of actual hgh.

 

[SSFITNESS]

Natural fluctuations in hormones are not significant enough to produce noticeable differences

Stop thinking in terms of mechanisms

The empirical data is conclusive

Natural fluctuations? Your body is either in an anabolic state or catabolic there's no in between. If your body is producing higher amounts of test, hgh, higher conversions of igf1, your nutrient partioning is at peak levels and your CNS is operating with the "fight" part of fight or flight then your in an anabolic state. In that state as long as the body is given exactly what it needs all the gear your taking will be far more effective. When your in a calorie rich environment for an extended period the body striving for homeostasis will start to introduce feedback loops that slow and even stop muscle gain. These feedback loops begin as your bodyfat levels rise. Your body will raise the metabolism to try to get rid of excess calories, when that fails it start to store bodyfat. As bf levels raise the bf cells produce estrogen which then blunts the body's natural testosterone production. When estrogen levels rise and testosterone levels decrease cortisol rises in the body which most definitely means your body is in a catabolic state. I think a perfect example of guys building unbelievable physiques on low cal diets is men's physique. These guys are starving to make weight and coming in looking better than the open class guys

 

[kadafi2]

It's good that the body is either in an anabolic or catabolic state. And that there's nothing in between. But this "in between" is precisely the homeostasis you write about a moment later. If the body in a state of catabolism "eats itself" and breaks down on its own, and in a state of anabolism "stores" proteins, then where is the state where it does neither one nor the other? Of course, I don't mean providing essential amino acids for survival, but "storing" them in the new muscle tissue being built.

A body that is in "fighting mode" all the time won't last long. It has to rest and regenerate. A mode like: fight - successful hunt - eat - sleep - and fight all over again the next day would probably be tiring for the body and mind. After all, once, after a successful hunt, they had supplies for a while. In the course of evolution, I think certain mechanisms have also changed.

What is also inconsistent is writing about natural hormone releases, cortisol, etc., and at the same time writing about taking exogenous GH and trenbolone. I don't know what to think about it, I think you can sum up the whole topic in one sentence: the lower the bf, the better the muscle building. Because as much as I like various interesting facts about the human body, here it has become a bit too much chaos.

 

[Stewie]

Under normal physiological reactions in the human body, anabolism and catabolism occurs simultaneously in skeletal muscle. Even in the presence of anabolic stimuli, there will still be catabolic reactions.

Some of the responses in this thread are erroneous on several different aspects of physiology and biology.

 

[qbkilla]

Under normal physiological reactions in the human body, anabolism and catabolism occurs simultaneously in skeletal muscle. Even in the presence of anabolic stimuli, there will still be catabolic reactions.

Some of the responses in this thread are erroneous on several different aspects of physiology and biology.

This is interesting. Curious your thoughts on people who say training frequency is important because we benefit from constantly spiking protein synthesis when we train a muscle group. How does this "spiking " of mps differ from when we spike protein synthesis by consuming dietary protein?

 

[Stewie]

This is interesting. Curious your thoughts on people who say training frequency is important because we benefit from constantly spiking protein synthesis when we train a muscle group. How does this "spiking " of mps differ from when we spike protein synthesis by consuming dietary protein?

The simplified differences. Mechanical stimulation activates distinct gene responses (via mechanotransduction pathways) that protein ingestion does not fully stimulate. The convergence of the two would create synergistic effects. That's as simple as it gets.

 

[Stewie]

"Second, despite the fact that most of the pathways regulating muscle mass, such as Insulin/IGF1 or TGFβ/Activin/BMP, impinge both on protein synthesis and degradation, changes in protein turnover leading to muscle hypertrophy or atrophy do not always proceed according to the simplistic view that muscle growth is consequent to increased protein synthesis and decreased protein degradation, while muscle atrophy results from decreased protein synthesis and increased protein degradation. In fact, exercise does promote the synthesis of new proteins but simultaneously activates autophagy–lysosome and ubiquitin–proteasome-degradative systems4. Conversely, during protein breakdown, the amino acids released by lysosome and proteasome directly stimulate mTOR5 and therefore, protein synthesis might increase during muscle atrophy."

https://www.nature.com/articles/s41467-020-20123-1

 

[Biggerp73]

Natural fluctuations? Your body is either in an anabolic state or catabolic there's no in between. If your body is producing higher amounts of test, hgh, higher conversions of igf1, your nutrient partioning is at peak levels and your CNS is operating with the "fight" part of fight or flight then your in an anabolic state. In that state as long as the body is given exactly what it needs all the gear your taking will be far more effective. When your in a calorie rich environment for an extended period the body striving for homeostasis will start to introduce feedback loops that slow and even stop muscle gain. These feedback loops begin as your bodyfat levels rise. Your body will raise the metabolism to try to get rid of excess calories, when that fails it start to store bodyfat. As bf levels raise the bf cells produce estrogen which then blunts the body's natural testosterone production. When estrogen levels rise and testosterone levels decrease cortisol rises in the body which most definitely means your body is in a catabolic state. I think a perfect example of guys building unbelievable physiques on low cal diets is men's physique. These guys are starving to make weight and coming in looking better than the open class guys

No, that’s because they aren’t abusing GH and Insulin year round in combination