A year later - Anyone still taking metformin?

[prodaf]

Im pretty sure it was in the ER version of Metformin, I just looked it up again through the FDA and all I could find was the ER Metformin info

Yes i saw some studies for ER.

 

[lookslikesausage]

Valisure

www.valisure.com

Some people also believe though that some of the medical community were overreacting. Not every brand had higher amounts of NDMA (NOT MDMA) though. Valisure did a study and put out many brands and the amount of NMDA in their product.

 

[aphextwin]

For those of you still using metformin are you still using extended release version or the instant release?!

Both but using the extended release form now.

 

[heavyhitter]

I'm curious about this too. I have a lot of the extended release variety that I'm considering adding to my regimen.

The er tends to give people less stomach issues

 

[beastmode121]

It make more sense to use the ER version if you’re bulking heavy on carbs.

 

[Apestrong]

I just drink scotch..puts me to
Sleep nicely

 

[heavyhitter]

I just drink scotch..puts me to
Sleep nicely

Pretty sure you’re talking about melatonin, not metformin

 

[Type-IIx]

Those "experts" really need to figure that whole PPAR thing out, all of them. You can add some metformin to it if you need to. It looks like there are enough cancer scares to go around.

I know I sometimes have a tendency to speak obliquely, but what are you saying? Met has arguably nothing to do with PPAR (perhaps some minor mechanism via PPARα/lipid metabolism). But PPAR is well-elucidated and Metformin has virtually nothing to do with it.

 

[b_cornelius]

I know I sometimes have a tendency to speak obliquely, but what are you saying? Met has arguably nothing to do with PPAR (perhaps some minor mechanism via PPARα/lipid metabolism). But PPAR is well-elucidated and Metformin has virtually nothing to do with it.

So you are saying that a chief nuclear factor regulating the processes of energy nutrients has nothing to do with a medical indication concerning this very idea? The very fact that people treat every pathway as interchangeable, only concerning themselves with superficial indications? The fact that berberine is the first thing that people bring up?

Otherwise Met and PPAR do cross paths, and you're right, Met isn't anything compared to PPAR except a good mitochondrial regulator. Also, elucidation is not necessarily hundreds of studies showing conflicting and contradictory results. All while experts in the sports sciences are not grasping it, at least in public, while pharma is intensionally stalling PPAR.

 

[buck]

Never stopped taking it.

 

[Type-IIx]

So you are saying that a chief nuclear factor regulating the processes of energy nutrients has nothing to do with a medical indication concerning this very idea? The very fact that people treat every pathway as interchangeable, only concerning themselves with superficial indications? The fact that berberine is the first thing that people bring up?

Otherwise Met and PPAR do cross paths, and you're right, Met isn't anything compared to PPAR except a good mitochondrial regulator. Also, elucidation is not necessarily hundreds of studies showing conflicting and contradictory results. All while experts in the sports sciences are not grasping it, at least in public, while pharma is intensionally stalling PPAR.

Met lowers blood glucose primarily by inhibiting mitochondrial complex I, no real published data on a PPAR mechanism.

PPAR are a group of nuclear receptors (i.e., fatty acids affect gene transcription via the PPAR receptors). PPARα affects lipid metabolism, δ glucose metabolism and muscle oxidative capacity, 𝛾 formation of new fat cells, FA uptake and storage and therefore insulin sensitivity. Broadly, activation of these receptors yields an antiartheriogenic/antiinflammatory state.

Fibrates are a class of compound that broadly activates PPAR, glitazones/thiazolidinediones activate PPAR𝛾 ⇒ ameliorated insulin sensitivity.

The only thing a delta agonist could provide that fibrates/glitazones don't already is increased "cholesterol efflux" to protect the arteries. Something not a single person putting this carcinogen in their body understands. Hopefully most of what's on the grey market is just fenofibrate or a generic statin.

 

[Reno911]

Has anyone had stomach issues with the XR version and "worked" through them? I've heard of you can handle the first 2-3 weeks your gut biome will adjust.

 

[warlock]

500mg in the AM and 500mg in the PM. Too many health benefits to ignore.

 

[warlock]

1,5grams a day(500am/1000pm), love it! I used berberine for a few months and for me wasn’t the same….

Why so much? Do you have blood glucose issues?

 

[j2048b]

ive got a script for both the er and regular release, i tried both and they made me hella dizzy...not sure why? maybe it lowered something way to low? dunno or i ate the carbs at the wrong times? dunno? but ive got it, hear all sorts of stuff about how great it is, but honestly not sure how to incorporate it with food and timing honestly....need some guidance as im not sure why it would cause dizziness....\

do u have to cut carbs or load or what? my doc put me on it because my insulin likes to naturally creep up and my blood sugar likes to dip, and vice versa...

 

[b-boy]

Has anyone had stomach issues with the XR version and "worked" through them? I've heard of you can handle the first 2-3 weeks your gut biome will adjust.

Yes I went thru periods of diarrhea when I first started metformin, in a couple weeks time it passed and never had it again while on metformin, I was taking the ER version.

 

[whacked]

Anyone get insomnia from Metformin?

“As already discussed, metformin can result in sleep disturbance, and this might affect normal dream patterns. Nightmares are reported in patients receiving metformin. Moreover, metformin as an insulin sensitizer can affect sleep via altering glucose metabolism. Metformin improves the neural glucose resorption and it can affect the nervous system health, and therefore affecting sleep quality”.

 

[tjitsu]

Why so much? Do you have blood glucose issues?

Not really, but it keeps my glucose at around 90 with GH.

 

[b_cornelius]

Met lowers blood glucose primarily by inhibiting mitochondrial complex I, no real published data on a PPAR mechanism.

PPAR are a group of nuclear receptors (i.e., fatty acids affect gene transcription via the PPAR receptors). PPARα affects lipid metabolism, δ glucose metabolism and muscle oxidative capacity, 𝛾 formation of new fat cells, FA uptake and storage and therefore insulin sensitivity. Broadly, activation of these receptors yields an antiartheriogenic/antiinflammatory state.

Fibrates are a class of compound that broadly activates PPAR, glitazones/thiazolidinediones activate PPAR𝛾 ⇒ ameliorated insulin sensitivity.

The only thing a delta agonist could provide that fibrates/glitazones don't already is increased "cholesterol efflux" to protect the arteries. Something not a single person putting this carcinogen in their body understands. Hopefully most of what's on the grey market is just fenofibrate or a generic statin.

There's a lot more to it than that. Your logic would have to contain more if,then statements.

Also, an association with cancer by no means implies carcinogenic. An ability to return progenator cells to a stem cell-like ability to reproduce is powerful. As with most of our gear here, if something else causes the cancer, it may quickly progress. Mostly, it's novel fusion ability can lead to tumor-like activity.

GW costs less than $7 a gram to produce, so there are not a lot of fakes. What the hell.

I'm pretty sure that I understand. There's a lot more to it than what you said, but some professionals could simplify it in a way that his/her clients could begin to use all of the subtypes fluidly with their diet and training.

But back to metformin.

 

[Apestrong]

Pretty sure you’re talking about melatonin, not metformin

No, metformin is running around giving everyone frantic foamy diarrhea..while that’s happening I can do a less severe version of that to myself with scotch and sleep peacefully