Progesterone converts to dihydroprogesterone which then converts to allopregenolone. That hormone cascade is important as they allostericly modulate gaba-a receptors acting like a natural benzodiazapine. Some other actions of include, improved mood, improved sex drive, neuroprotection, increased BDNF, increased synthesis of myelin in the nervous system, and antidepressant effects anti anxiety effects. From personal experience, I did not know what I was missing until I tried transdermal progesterone, it is truly life changing fo me. Dhea is beneficial for me as well, I nearly stopped getting sick entirely after adding dhea as well as a slight mood improvement. I get wired and bloated from pregenolone so I dropped it.