Short esters, particularly nandrolone and tren, are heavy stress on the kidneys.
Drugs like anavar kept metabolized primarily by the kidneys. Winstrol also has heavy stress on kidneys.
Creatine, high protein diets, stimulants... All heavily impact kidneys.
Adrenal glands top your kidneys.
None of this is "imaginary", and yes when your adrenals get shot, you feel tired and like shit.
How i WISH what you said were true so i can recklessly use these things without a worry, but I assure you when i bang out short esters, var, creatine and intense lifting on a high protein diet, it's not coincidence i start feeling worn out and shitty.