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AI's ..and the body's tolerance.

Big Vin

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Does the body develop a tolerance for AI's? Could one theoretically run exemestane perpetually? I run exemestane and anastrozole consecutively on a blast/cruise protocol.
My thinking is that the body may get used to one or the other if run too long. Maybe it won't be quite as effective. Anyone have any insight here?
 
Does the body develop a tolerance for AI's? Could one theoretically run exemestane perpetually? I run exemestane and anastrozole consecutively on a blast/cruise protocol.
My thinking is that the body may get used to one or the other if run too long. Maybe it won't be quite as effective. Anyone have any insight here?

No tolerance.
Look at your e2 numbers over time do they get worse using the same doses of aas and ai? All the supposition in the world is moot when you merely look at your bloodwork numbers. They are truly all that matters
 
The numbers have been good, but this has been using the above mentioned protocol. (Adex, then Aromasin) I would love to use Aromasin exclusively. Thinking of giving it a go and checking out the numbers over time.
 
Most people using an AI long term actually do show a slow increase in E2 levels over time. I wouldn't assume this is from the AI however, I think taking test, even replacement doses, stimulates the body to try and metabolize testosterone faster, thus more aromatization. Taking an AI also slightly increases conversion to DHT and taking a 5AR slightly increases conversion to E2, slow down one pathway, increases the other...
 
I use script aromasin every other day, keeps e2 levels level with 200mg test a week
 
I hope you don't build up a tolerance. That would be bad for all of us TRTers.
 
no tolerance

this topic has been discussed before, use the search engine and ull find evidence that supports that there is no tolerance

id do the search for you, but im kinda lazy tonight, however for memory i remember reading a study on breast cancer patients using letrozole for 1 year and no reported tolerance was noted, and estrogen level remained suppressed for the entire duration consistently

thats the most i remember
 
Thanks for your response and congrats on "featured member" bro!
 

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