Anybody else get indigestion from Cardarine??

[Gunsmith]

This is my third time taking Cardarine and after the second day I have the worst indigestion all day and night (dosed every 12hr) each time I used a different brand but each time I always get indigestion from it.
I don't know exactly what could be the reason for Cardarine causing it but about 24 hr after the last dose it subsides then after it's started again it comes right back within a couple hrs of the first dose.
Anyone else notice this or what about the Cardarine could be the cause???

 

[Fa Seeshus]

Was it a liquid suspension, a pill or straight powder? Also did you take with food. Are you on orals or tren? Lot of variables

 

[Ace0]

I get indigestion only if I have had a relatively high amount of GH with it that day. It’s totally weird side effect with no evidence but something I’ve anecdotally noticed.

 

[Fa Seeshus]

Just looked up some more stuff about cardarine. The main pathway it works through is by activating PPAR-delta which is normally triggered through exercise and sun exposure. PPAR-Delta receptors are the highest in your digestive tract... Therefore taking an oral agonist could definitely result in this indigestion.

Role of peroxisome-proliferator-activated receptor beta/delta (PPARbeta/delta) in gastrointestinal tract function and disease - PubMed

PPARbeta/delta (peroxisome-proliferator-activated receptor beta/delta) is one of three PPARs in the nuclear hormone receptor superfamily that are collectively involved in the control of lipid homoeostasis among other functions. PPARbeta/delta not only acts as a ligand-activated transcription...

pubmed.ncbi.nlm.nih.gov

Come to think of it I used to take Cardarine on an empty stomach before yoga class and I ended up with a ton of digestive issues... Just never made the connection until now. Now I eat and take all my pills a few minutes after and haven't been having those issues.

 

[samson516]

Been taking Cardarine for about 6 weeks now with no digestive issues. I always take mine with food though...mainly with my post workout protein shake or with breakfast.