Anyone have any more insight on this stuff?

CDJack · Sep 6, 2012

This stuff could really save us all from possible heart failure later in life...

TAKEN FROM ANOTHER BOARD:

The heart medication you never even heard of

The best kept secret in the industry is this, there are medications that will protect the heart from the effects of steroids, now this is not something to use long term but lets cover the medication first, then the studies linking testosterone use to heart problems. I know that seems backwards but humor me.

Trimetazidine
(theheart.org: trusted cardiology news and opinions)

Trimetazidine is a fatty acid oxidation inhibitor, what this means is that it forces the heart to use glucose for energy, reducing lipid peroxidation. It works by blocking an enzyme called ‘3-KAT’, this enzyme is involved in fat oxidation and Trimetazidine will reduce fat oxidation by about 10% (roughly). It also improves coronary flow reserve which also improves exercise performance. Not only does this medication reduce the oxidative stress that is placed on the heart but it gets better it also raises your HDL levels. Seriously, and yet it is not approved for use in the US, can’t make this stuff up folks. It also more than likely has other cardio protective effects that have yet to be discovered by their method of action AND has been shown to be fairly well tolerated with few side effects and no known contraindications.

You can learn more about this wonderful drug here:
Trimetazidine, a Metabolic Modulator, Has Cardiac and Extracardiac Benefits in Idiopathic Dilated Cardiomyopathy
Trimetazidine: a meta-analysis of randomised controlled trials in heart failure -- Gao et al. 97 (4): 278 -- Heart

Dosing for this would be let’s say 20mg twice a day (in the mornings and evenings), this will insure you will see the benefits from the drug and have few (if any) side effects from it. I can bet that most of you will have no problems with running that dose and your heart and lipids will thank you.

Thor · Sep 6, 2012

Good info..

is it available yet ? script needed?

Ruhlfreak55 · Sep 6, 2012

this is intriguing...

CDJack · Sep 6, 2012

Thor said:
is it available yet ? script needed?

"But despite "impressive" effects, trimetazidine would have to tackle unique challenges before making headway in the heart-failure market. As Tang points out in his editorial, trimetazidine as a heart-failure drug faces a uniquely arduous approval process in the US, partly because it is already marketed elsewhere for a separate, long-standing indication. While it is not available in the US at all, trimetazidine is approved and sold for the treatment of stable angina in Europe and Asia and is even available generically in certain countries, despite ongoing debate over its role in angina management, Tang notes. Heart-failure studies have been more consistent and support its beneficial effects on LVEF, but no large, randomized, clinical trial has demonstrated an impact on hard end points—a prerequisite for FDA approval."

There are several places to get it online. Just wondering if anyone else has tried it or is looking into it. These studies seem to be 2-3 years old, so I wonder if anything has developed.

CDJack · Sep 6, 2012

Further to our previous observation of post-mortem cardiac lesions after sudden death in several athletes with a history of anabolic steroid abuse, this study was intended to reproduce these lesions in rabbits administered testosterone oenanthate, a prototypic anabolic steroid abused by athletes, and to provide evidence for the protective effects of trimetazidine and dexrazoxane that are used as antianginal and cardioprotective drugs, respectively. Groups of six rabbits each were administered saline, testosterone, or a combination of testosterone and either trimetazidine or dexrazoxane for 3 months. Histologic cardiac lesions including necrosis, misshapen cell nuclei, interstitial and endocardial fibrosis, lymphocytic infiltrates, and vascular dystrophies were observed in testosterone-treated rabbits. In contrast, no significant lesions were observed in the animals treated with testosterone combined with either trimetazidine or dexrazoxane. This is the first study providing evidence for testosterone cardiotoxicity following sub-chronic exposure in laboratory animals. In addition, these results suggest the protective role of trimetazidine and dexrazoxane.

Kaladryn · Sep 6, 2012

I did some research on this stuff, surprising lack of info. Seems like this drug could have suffered from the standard "off patent so drug companies shut it down" kind of thing... Interesting, I'm going to read more.