alfresco
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The problem with higher reps is that on some exercises they are way more taxing and programming becomes an issue. Even at a much lower volume it can run you into the ground. The quad component of a leg workout might look like this:
Squats
Leg presses
Hack squats
Two work sets to failure; 6-8 and 10-12 for example. I think most people have probably done something similar at some point and that can be tough, but manageable. Now take the same workout and try to do it as 12-16 and 16-20. That will 100% destroy you if you take those sets to true failure. Much more than the lower rep ranges.
Injuries can occur in any rep range, but it's the training to failure that increases this risk. It's only in bodybuilding where programs revolve and are based around failure. In the other parts of the lifting community (powerlifting, strongman, olympic) it's either not used or used rarely. And while I know their goal isn't muscular development there are some thick people from those sports. The whole intensity (failure) above all else in training is largely a western mindset. Eastern Bloc countries like Russia, Iceland, Germany etc laugh at the way we train in North America.
I'd be curious to hear @Ben Pollack comment on this as he comes from powerlifting where low reps, volume, and not training to failure are part of the programming and how as people get older how they can keep training without necessarily doing only 15+ reps on everything.