Purpose: Osteoarthritis is the single most common cause of disability in older adults with an estimated 10% to 15% prevalence in individuals above 60 years. The contemporary medications include nonsteroidal anti-inflammatory drugs acetaminophen, cyclooxygenase-2 ...
www.ncbi.nlm.nih.gov
I also added Longvida because it has the ability to cross the blood brain barrier.
With respect to that reference. A few things i noticed on that study
There "control" group was ibuprofen dosed at 400mg once daily in the AM
The "study" group was the SLCP.
The issue i have with it is i can probably find dozens of studies showing placebo effect in pain control for OA and other types of patients. They needed to have a true placebo group not ibuprofen as the control preferrably with a cross over.
Ibuprofen has a half life of like 2 hours... so essentially for 16 hours a day its not working and thats what they compared to.
If you look at the inflammatory markers for SLCP ( IL, LTB and TNF) they all went down for ibuprofen and *increased* not stat sig, for SLCP. Its not stat sig but it is across the board consistent on that study ( maybe underpowered ?).
Its good they looked at CTX2 but you have to look at the inclusion criteria.... for ctx2 you arent generally gonna get a urine spike unless it goes inflammatory OA phase. In there inclusion criteria they used some vague language by saying " LIKE knee pain,crepitus, osteophytes etc" By using the term LIKE that doesnt mean they needed to have all that criteria nor does it actually mean that have significant OA.... i like to see studies that actually SHOW the OA not just oh ur 50 and have some knee pain.
If you also look at the study more people dropped out of the study group then the control..but again not stat sig but these non stat sig findings keep adding up which makes me think it was underpowered.
So in summary this is what i was kinda referring to in another thread ( or maybe it was this one lol) when i said a lot of these studies have a too many holes in them. Maybe there are better done studies but truthfully this isnt one.
Also since there are so many skeptics on this board... this study was funded by Pharmanza Herbals and done in india with some of the authors representing that herbal company..