Supplements formulated with berberine and silymarin may improve blood lipid levels and fasting blood sugar levels, says a meta-analysis of five randomized, double‐blind, placebo‐controlled clinical trials (RCTs).
Personally, I am not sold on Dihydroberberine yet but I suppose it could have merit.
I have used it with good results. GI motility is what I noticed + gastric dump efficiency. After studying folk medicine I notice a few cultures recommend it for digestion.
here is a copy and paste from selfhacked for some lab examples, this article says berberine is found in goldenseal roots wtf? goldenseal is a potent immune system compound often stacked with echinacea
Goldenseal (Hydrastis canadensis), native to North America, is an herb that has been traditionally used to fight infections. Much of modern research has focused on berberine, a bitter compound found in Goldenseal roots with many medicinal qualities .
Berberine is a natural, safe anti-diarrheal. In a clinical trial with 196 people with irritable bowel syndrome (IBS), berberine significantly reduced diarrhea frequency and stomach pain, improving the quality of life .
In another clinical trial with 165 people, berberine stopped diarrhea due to E. coli in 42% of the cases after just 1 day of use .
In human and rat studies, berberine from goldenseal significantly speeds up digestion, reducing the time it takes for food to travel through the small intestine [27, 28].
In rats, berberine reduced gut inflammation (possibly by reducing lipid peroxidation and NF-κB levels). In diabetic rats, it helped restore the gut barrier and improved nutrient absorption [29, 30, 31, 32, 33, 34].
Berberine might be helpful for clearing toxins that reach the blood in people with leaky gut, such as LPS. In mice with high LPS (endotoxemia), it helped prevent leaky gut. In a gut tissue study, it blocked about 70% of the toxins produced by gut bacteria (Vibrio cholerae and E. coli) [35, 36].
I've been using the Nutricost brand for a while. So far so good. I do like Nutricost's products other products as well. A friend of mine works in the supplement manufacturing business and has said that their products are solid.