Bloodwork thoughts?

[rookx750]

I'm guessing you did a little run of long acting tren recently? What is bodyfat %? It is very unusual for 200mg of test to bring e2 that high, that normally takes closer to 500mg to get close to 100 e2 without an AI, you may need the "sensitive" test to make it accurate...

K so over the years you probably have see tons of bloods, and I know everyone is different but it would be safe to say you see a 1 to 5 raitio of E to T?

Hypothetically what are your thoughts on running mast or prov with test as far as actually bringing down estrogen level through different pathways? On paper it should not drop estrogen at all but have you seen it?

I understand that it cosmetics effects kinds mimic an AI but I have heard BUT never read, where it does have effects on the conversation ( things like it will help prevent gyno...exc)but not necessarily bring the number down on paper


What’s your thoughts? Would a dht like mast or prov have more side effects than an AI or viceversa. Talking about trt dosages of all(lol I know those compnds aren’t officially trt but just saying)

 

[Kaladryn]

K so over the years you probably have see tons of bloods, and I know everyone is different but it would be safe to say you see a 1 to 5 raitio of E to T?

Hypothetically what are your thoughts on running mast or prov with test as far as actually bringing down estrogen level through different pathways? On paper it should not drop estrogen at all but have you seen it?

I understand that it cosmetics effects kinds mimic an AI but I have heard BUT never read, where it does have effects on the conversation ( things like it will help prevent gyno...exc)but not necessarily bring the number down on paper


What’s your thoughts? Would a dht like mast or prov have more side effects than an AI or viceversa. Talking about trt dosages of all(lol I know those compnds aren’t officially trt but just saying)

All the non-AIs that have "some" anti-estrogenic effect have such a tiny amount compared to real AIs it is ridiculous. And usually "freeing up SHBG bound test" is said as a positive, when we have learned in the last few decades that SHBG has a membrane receptor and isn't a storage only mechanism as once thought.

 

[Stewie]

All the non-AIs that have "some" anti-estrogenic effect have such a tiny amount compared to real AIs it is ridiculous. And usually "freeing up SHBG bound test" is said as a positive, when we have learned in the last few decades that SHBG has a membrane receptor and isn't a storage only mechanism as once thought.

Megalin and cubilin help intercellular integrity of sex hormones locally in SHBG. Essentially debunking thee free hormone hypothesis.

Thee 'free hormone hypothesis' has been of belief that bound hormones to SHBG are inactive. Tho, there's the belief that megalin interacts with SHBG allowing internalization of ligands to initiate conformation to it's target receptor.

What to believe, what to believe?

Given that, free hormones are considered bioavailable, loosely bound to carrier proteins. So the hypothesis is that the lower one's SHBG is, the more active estradiol is.

Then we have those that respond better to andogens is under belief is related to individualized CAG repeats lenght, shorter being the king $hit.

 

[Kaladryn]

SHBG is obviously much more complex than once thought, considering how extensive it's functions are and also possibly unknown, it seems unwise to assume raising or lowering it would be beneficial at this point. It is probably performing some function when it is high or low and that function may not be counterproductive to bodybuilding, there is no reason to assume it is...