Bodybuilders got it right again

[nothuman]

Nebivolol has pretty much been known as a bodybuilding ancillary drug for nearly a decade despite it being rarely prescribed by cardiologists unless the patient really insists. It is popular obviously because of its ability to lower blood pressure and heart rate, but also because it doesn’t have the same side effects of other beta blockers, like insulin resistance or reduced aerobic capacity. Here is a new study in a top-tier journal showing improved outcomes compared to other beta blockers, which was unsurprising to me given it’s nitric oxide boosting effects, but we haven’t had good data comparing them until now.

https://www.ahajournals.org/doi/10.1161/JAHA.125.044910

Bodybuilders were once again ahead of the curb on this one.

 

[KyleSmith1985]

CONCLUSIONS​

In this large, real‐world cohort of patients with hypertension without heart failure, nebivolol use was associated with greater reductions in BP and heart rate, as well as a lower risk of all‐cause mortality and major cardiovascular events, compared with carvedilol and other commonly prescribed beta blockers. These findings suggest a potential role for nebivolol in managing hypertension in patients without heart failure, particularly within Taiwanese populations. However, as this was a retrospective cohort study, residual confounding cannot be excluded, and confirmation in a prospective randomized trial is warranted.
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When I asked my Doc for Neb he prescribed me Clonidine. Thank god for India Pharma. on GH and Reta I am taking 15mg/day of Nebiv

 

[Sectør]

I’ve enjoyed the combination of telmisartan and Nebivolol for blood pressure (and heart rate control)

40mg telmisartan ed + 5mg Nebivolol has worked perfectly for me. Might be a better option than going for higher dose Nebivolol as a standalone?

 

[nothuman]

I’ve enjoyed the combination of telmisartan and Nebivolol for blood pressure (and heart rate control)

40mg telmisartan ed + 5mg Nebivolol has worked perfectly for me. Might be a better option than going for higher dose Nebivolol as a standalone?

Combination therapy is almost always better for this. Both have mutually exclusive benefits.