can i get some info and feedback on TARGEX-1?

[bigbaldbulldog]

i would liek some info and feedback on this topical gel

how much to use
how often
how long

Thanxs

 

[Rex Feral]

YHPM.

Rex.

 

[bigbaldbulldog]

got your PM and info thanks buddy..

 

[haze324]

Whats up brother...you gonna give it a whirl and let us know how it goes for ya??

Sounds interesting and the prods this guy has have great prices.

 

[chaos1]

comes in a pump top bottle. 3 pumps AM, and 3 before bed.

here is a little info.

Targex 1 is Glycyrrhetinic acid in a topical oil based gel.

Here's a study on Glycyrrhetinic acid from pub med:

Steroids. 2005 Jul;70(8):538-42. Epub 2005 Apr 12.

Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application.

Armanini D, Nacamulli D, Francini-Pesenti F, Battagin G, Ragazzi E, Fiore C.
Department of Medical and Surgical Sciences-Endocrinology, University of Padua, Via Ospedale 105, 35100 Padua, Italy.

Cortisol is involved in the distribution and deposition of fat, and its action is regulated by the activity of 11beta-hydroxysteroid dehydrogenase. Glycyrrhetinic acid, the active principle of licorice root, blocks 11beta-hydroxysteroid dehydrogenase type 1, thus reducing the availability of cortisol at the level of adipocytes. We evaluated the effect of topical application of a cream containing glycyrrhetinic acid in the thickness of fat at the level of the thigh. Eighteen healthy women (age range 20-33 years) with normal BMI were randomly allocated to treatment, at the level of the dominant thigh, with a cream containing 2.5% glycyrrhetinic acid (n=9) or with a placebo cream containing the excipients alone (n=9). Before and after 1 month of treatment both the circumference and the thickness of the superficial fat layer of the thighs (by ultrasound analysis) were measured. The circumference and the thickness of the superficial fat layer were significantly reduced in comparison to the controlateral untreated thigh and to control subjects treated with the placebo cream. No changes were observed in blood pressure, plasma renin activity, plasma aldosterone or cortisol. The effect of glycyrrhetinic acid on the thickness of subcutaneous fat was likely related to a block of 11beta-hydroxysteroid dehydrogenase type 1 at the level of fat cells; therefore, glycyrrhetinic acid could be effectively used in the reduction of unwanted local fat accumulation.

Publication Types:

* Clinical Trial
* Randomized Controlled Trial


PMID: 15894038 [PubMed - indexed for MEDLINE]

The interesting thing about that study is that "No changes were observed in blood pressure, plasma renin activity, plasma aldosterone or cortisol." meaning it didn't result in systemic fat loss, but true sport reduction in subcutaneous fat. Pretty sweet stuff, and the product was getting rave reviews.

 

[Ashop]

anyone used this with success?

 

[chaos1]

anyone used this with success?

cbl used to sell it on outlaw. there is some very good feedback there.

 

[n4dmoney]

I'm giving it a run now. I will keep you guys posted....