- Joined
- Jan 4, 2008
- Messages
- 76
Been ressearching Formastane and came across this info on some "real clinical reasearch" that was done on it.
4-Hydroxyandrostenedione has also been given orally. Even though there is a marked first-pass effect with conversion in the liver to a glucuronidated derivative, oral doses of 250 mg reduce plasma estradiol by 53% and doses up to 1,000 mg produce no further suppression. The response rate after 3 months of therapy was 33%, and the only serious side effect from the oral dosage was leukopenia in a single patient.38
Formastane is supposed to reduce E2 fairly quickly after you administer it, within a few days and top out at about 50% E2 reduction. My question is whats in bold about the 33% after 3 months.
Does than mean after 3 months usage, instead of blocking 50% E2 it will only be blocking 33% so after about 4 months use ur body wont respond to it very much so you would need to switch to another AI, is that what that means??
4-Hydroxyandrostenedione has also been given orally. Even though there is a marked first-pass effect with conversion in the liver to a glucuronidated derivative, oral doses of 250 mg reduce plasma estradiol by 53% and doses up to 1,000 mg produce no further suppression. The response rate after 3 months of therapy was 33%, and the only serious side effect from the oral dosage was leukopenia in a single patient.38
Formastane is supposed to reduce E2 fairly quickly after you administer it, within a few days and top out at about 50% E2 reduction. My question is whats in bold about the 33% after 3 months.
Does than mean after 3 months usage, instead of blocking 50% E2 it will only be blocking 33% so after about 4 months use ur body wont respond to it very much so you would need to switch to another AI, is that what that means??