cardarine, nac,tudca

[Bobik]

Damm you right I forgot udca is better than tudca

yes, i am taking UDCA pharmacy and my liver values are fine ... 250-500mg / day

 

[deadliftsquates]

I wouldn't necessarily say that. In fact, TUDCA appears to be superior. See below (pay attention to the red bolded text).

The Science of Parkinson's
Plain English information about the research being conducted on Parkinson's​

• ABOUT
• ALPHA SYNUCLEIN
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• WHAT IS PARKINSON’S?

UDCA 2.0 = TUDCA?
APRIL 16, 2018

Ursodeoxycholic acid (UDCA) has been proposed as a drug that could be repurposed for Parkinson’s. As a medication, it is called ‘Ursodiol‘ and it is used to treat gallstones. But there are absorption issues with UDCA: The passage of UDCA through the wall of the small intestine is slow and incomplete (Source). There may be a solution, however, called Tauroursodeoxycholic acid (TUDCA). Think of it as UDCA-2.0. It is more easily absorbed by the gut. And there is also good evidence to suggest that it has the same beneficial neuroprotective properties as UDCA. In today’s post we will discuss what exactly UDCA and TUDCA are, review the Parkinson’s research for both, and discuss why one of these drugs should be tested in the clinic for PD.

Following oral administration, the majority of ursodiol is absorbed by passive diffusion (a slow and inefficient process) and its absorption is incomplete – some of the drug journeys all the way along the gastrointestinal tract and is excreted. For the portion that is absorbed, ursodiol undergoes liver extraction to the extent of about 50% in the absence of liver disease.

Given this absorption issue, some researchers have turned their attention to an alternative version of UDCA, called TUDCA.

What is TUDCA?

TUDCA stands for Tauroursodeoxycholic acid.



Tauroursodeoxycholic acid. Source: Wikipedia

TUDCA is the taurine conjugate form of UDCA – this means that TUDCA is created when a molecule of the organic compound taurine is added to the UDCA structure (see image below).



The difference between UDCA (top) and TUDCA (bottom). Source: Anabolicminds

TUDCA is naturally produced, but in very small amounts.

Importantly, after oral administration, the TUDCA is absorbed by the gut via both active processes and passive diffusion. TUDCA appears to raise bile levels of UDCA more effectively than UDCA itself (Source & source). This is most likely due to the taurine molecules enhancing bioavailability – the process of binding a taurine molecule to UDCA is a ‘rate-limiting step’ (it slows down the absorption process), which could be avoided by simply starting with TUDCA.

I didn't read this but Mike isn't wrong very often. lol All I know is my shit was fucked up and the little support cycle (above) I ran worked amazing. My dr was even surprised. I prefer to buy pharma UDCA than tudca from a supplement company.

 

[deadliftsquates]

yes, i am taking UDCA pharmacy and my liver values are fine ... 250-500mg / day

This seems low if I remember correctly I thought the caps were 300 mg and I would take 3 a day.

 

[Bobik]

This seems low if I remember correctly I thought the caps were 300 mg and I would take 3 a day.

I no longer use oral AS and this dose is enough for my good liver values. I monitor my blood regularly .... my capsules are 250mg from EU pharmacy.

 

[deadliftsquates]

Bo, I wasn't doubting you. I think it's great that you are getting results with the low dose.