When it comes to evaluating liver toxicity with orals, rather than looking at it from a "number of compounds" standpoint, you should look at it from a "total toxic load" standpoint.
In other words, the number of compounds you run doesn't necessary determine how hard a cycle is on your liver. It is the total amount of liver stress that matters. For example, it would be easier on the liver to run 25 mg of Anadrol, 30 mg of Anavar, and 10 mg of halotestin than it would 100 mg of Dianabol alone, even though the first option includes 3 orals and the latter just one. Now, I am not recommending that anyone run this particular cycle, but just using it as an example to get my point across.
Obviously, we don't have a medically accepted toxicity scale for oral AAS, but anyone who has been around a while will probably have a pretty good idea of how the various orals compare against each other on a per mg basis, as well as how their own body responds to them.
With that said, there are several awesome oral combinations that can be safely used (from a liver health standpoint), but you always need to remain cognizant of your total toxic load. As the dose of one oral rises, the dose of another must go down so that total toxic load does not exceed your target range. As long as you stay within a safe range, it really doesn't matter what orals you combine.
When it comes to pre-contest use, guys have been stacking orals forever...because the benefits are obvious, but off-season oral use has been a bit more ambiguous, with some guys using only one oral and others combining two or more. In my experience, if someone is using orals in the off-season in order to break past a plateau, I see little need to stack more than two at a time.
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