I'm confused as to where the tren comes in? I get that both don't work via the AR but why does that them work well together? Also what happens when too many compounds are used that use the AR? Does a lot of the AS go unused? Thanks for
It's a good question. Please keep in mind, my answers are based upon my reading thus far, so it's incomplete in its understanding:
To what I've read, trenbolone has a very strong affinity to bind tightly to the A.R. (Androgen Receptors). Much more than testosterone and when present with other A.R. binding agents, tren may actually bind first due to its strength. Depending on the amount of tren used, most of the other androgen agents may be may be locked out, and free to circulate within the blood. There's a post here on this forum "Laws of Trenbolone" that makes a strong case for high tren/low test cycles to lessen or completely avoid negative tren sides by reducing test to only 150-200 per week. The writer gives a colorful explanation:
" After this experience, Testosterone is simply a weak and inefficient steroid next to Trenbolone. In my mind, when you couple such a powerful drug like Trenbolone at a moderate to high dosage, with a high dosage of Testosterone, you leave LOTS and LOTS of unbound hormone flowing around mindlessly in your body. Since Trenbolone attaches to the receptor site first, and there is high dosages of Testosterone in the mix as well, its as if Testosterone is roaming the streets looting stores, stealing cars, breaking windows (high blood pressure, insomnia, night sweats). "
...thus it's best to keep any other androgens minimal to let tren do it's work.
Anadrol binds poorly to the A.R., as one website notates a clinical study's finding "Relative Binding Affinity = too low to be determined". Thus, it
might be good to use with tren, as it won't compete at the site, as well it's anabolic affects are mediated through a different (unknown?) path. Anadrol has an Androgen/Anabolic rating of 45/320, making it highly anabolic, as it's DHT derived and it's not a progestin. Like winstrol, it has been found to lower SHBG, and as steroid.com notates from another study "...Oxymetholone has been used in studies to alter the female reproductive/menstrual cycle; in those cases, it has lowered plasma progesterone levels"
All of this is academic in nature, as I've never ran both together. As with any other medication, all actions within the body (positive or negative) will be from the user's own body chemistry and its ability to handle these compounds and given dose factors.
Sent from my iPhone using Tapatalk