Consolidated Liver Enzyme Post | High ALT and AST

[CodeGorilla]

So I went on a 1.5 year mountain dew + slushy bender and developed fatty liver. (I didn't drink pop when I was a kid and I was never really warned off sugar -- even though I did "use it" as a way of dealing with depression). I have rarely drunk alcohol in my life. I came to the realization that my blood sugar and liver enzymes were out of whack at the beginning of 2025 (after a cat scan and bloodwork); I do not have hepatitis and will be doing a fibroscan shortly. Simply by getting rid of all the sugary drinks, I cleared up my blood sugar issue and I had hoped that that would get rid of my fatty liver. It did not. So I did my first cut in my life and went from 340 to 305 lbs (starting in July). My mid section looks a lot better and I don't think i lost much muscle.

However, I got blood work done today and my ALT and AST are further out of range. This is to be expected as I ended a tren/winny/clen/test prop cycle a few weeks ago and am cruising on 15 mg/day test prop. I am not sure if I made a mistake today by going on a long fasting walk right before the test but I haven't done heavy lifting in a few days. Everything else is in range except for "Immature Granulocyte Absolute Count (0.07 "high" with healthy threshold of 0.04 (used as a marker for inflammation)) and my HDL is low (37 with normal range >=40). I did not get GGT done but will have my doctor check that in the future; I am willing to assume at this point that the liver response is mostly toxicity from my cycle and not from heavy training.



A few questions:
1) How long will it take for my liver enzymes to go back to normal after a tren cycle? I think I am 2 weeks off tren at this point. I've read through various posts that the liver corrects itself fairly quickly (at least in comparison to lipids).
2) What body fat percentage am I going to need to get done to to kill the fatty liver?
3) I've been trying to put these liver enzyme numbers in context. I've accepted the risk of AAS use and I am ok with the idea of (slight exageration) "killing myself slowly." (Dying at 65 of a heart attack is ok by me but not at 47. I am 45 now) So I wonder if any of the fact finding I've done in existing posts on this forum are true:
A. "ALT and AST are elevated even 5 days after heavy exercise. So I would take an even longer break before bloodwork. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291230/" https://www.professionalmuscle.com/...s-continue-to-be-high-long-term.140255/page-2
B.

 

[Brocksamson2.0]

Invest in some Synthergine

 

[CodeGorilla]

I lost all my research by closing the forum window. I'll try to reproduce:

B. Bro came off coriticosteroids and his liver enzymes levels dropped after a month. ALT from 70 to 52 and AST from 19 to 23. https://www.professionalmuscle.com/...ently-elevated-alt.118016/page-3#post-2039715
C. "On day 1 postexercise, six subjects showed AST above the upper reference limit, whereas none of the subjects showed increased ALT. On day 2 post exercise, five subjects showed an increased ALT. All 14 subjects had AST above the upper reference limit 3, 4 and 5 days post exercise... The maximum increase in ALT was 4.1 µkat l−1." https://pmc.ncbi.nlm.nih.gov/articles/PMC2291230/ A google search indicates 4.1 µkat l−1 is 246 U/L (is that right)?
D. "My liver panel numbers are ALT 179, AST 112, ALP 78, total bilirubin 78, albumin 45, and total protein 77. My understanding is that ALT and AST are elevated, and the rest is good. Does the high ALT indicate cirrhosis?... Doctor: The high ALT and AST do not indicate that you do have cirrhosis, but yes, it cannot be ruled out based on these tests." https://www.icliniq.com/qa/liver-ci...e-to-excessive-drinking-before-getting-tested

I have TUDCA and glutathione on hand. I guess I could look at Synthergine."

 

[Duke309]

I had some non-alcoholic fatty liver indications on an MRI a couple years ago and my AST/ALT are always ~20 points high out of range since I don't take off training when I get blood work. Take 7 days off from the gym if you want a true indication of AST/ALT, however that doesn't really tell you anything. Having a low normal GGT will give you an indication of your liver health. The fibroscan will let you know if you have any scarring or cirrhosis.

I'd recommend using glutathione (I used roughly 200mg 3x per week) and retatrutide (I used at least 250 mcg per day) while dropping weight to reduce/eliminate the fatty liver. The glp1s, especially reta have been fantastic at reducing fatty liver.

 

[CodeGorilla]

The GLP's do something more than just block hunger? Increase in metabolism somehow too?

 

[CodeGorilla]

I lost all my research by closing the forum window. I'll try to reproduce:

B. Bro came off coriticosteroids and his liver enzymes levels dropped after a month. ALT from 70 to 52 and AST from 19 to 23. https://www.professionalmuscle.com/...ently-elevated-alt.118016/page-3#post-2039715
C. "On day 1 postexercise, six subjects showed AST above the upper reference limit, whereas none of the subjects showed increased ALT. On day 2 post exercise, five subjects showed an increased ALT. All 14 subjects had AST above the upper reference limit 3, 4 and 5 days post exercise... The maximum increase in ALT was 4.1 µkat l−1." https://pmc.ncbi.nlm.nih.gov/articles/PMC2291230/ A google search indicates 4.1 µkat l−1 is 246 U/L (is that right)?

 

[CodeGorilla]

Wow... "Retatrutide is an experimental drug that has shown significant promise in reducing liver fat in patients with nonalcoholic fatty liver disease (NAFLD). In clinical trials, over 85% of participants treated with retatrutide experienced resolution of fatty liver disease, indicating its potential as a treatment option for this condition."

Doctors are only partially useful. You have to have a place like this to come to figure it all out.

 

[Simon90]

I had alt in the 1000s. To this day they don't know what caused it, all other values normal, ultrasound and mri normal, biopsy normal. Still wonder what the cause was to this day.

 

[Siggy]

I had alt in the 1000s. To this day they don't know what caused it, all other values normal, ultrasound and mri normal, biopsy normal. Still wonder what the cause was to this day.

Scary. You werent on any gear or orals?

 

[Simon90]

Scary. You werent on any gear or orals?

I was off at the time, not eating as much, hiking and climbing alot. Thought I was the fittest I'd ever been, went into a and e unrelated and they flagged the alt from the bloods they'd pulled or I'd have never known

 

[hogan87]

you are still over 300#, obese. You don`t need tren, clen, winstrol! Geez F`ing A. TRT and train, eat right, be hungry once in a while. If you are doing those right, at your body fat, fat should come pouring off of you. Get that body fat to 15 % before touching that stuff and by then your liver enzymes should be better.

 

[CodeGorilla]

a beast. not obese.

I actually did waste my first clen cycle on my current fatty state. I didn't even have my calories low enough for it to make sense when I first started. My first cut cycle.

 

[nicocujo]

I was off at the time, not eating as much, hiking and climbing alot. Thought I was the fittest I'd ever been, went into a and e unrelated and they flagged the alt from the bloods they'd pulled or I'd have never known

Sounds like you pushed your body into Rhabdo. It'll raise the ALT quite a bit.

 

[gib68sg]

a beast. not obese.

I actually did waste my first clen cycle on my current fatty state. I didn't even have my calories low enough for it to make sense when I first started. My first cut cycle.

Well, how tall are you? What’s your body fat looking like? If you want real help from people, the only way to get real answers is by giving all of the information available.

 

[hogan87]

a beast. not obese.

I actually did waste my first clen cycle on my current fatty state. I didn't even have my calories low enough for it to make sense when I first started. My first cut cycle.

coming off a 1.5 year mountain dew + slushy bender, 340# ... I`ll stand by my obese until proven otherwise.

Forget about me, be real with yourself. I`m not trying to put you down, but help you understand that from where you are, basics are the most important, and all that is needed, not more drugs.

 

[pimpman]

a beast. not obese.

I actually did waste my first clen cycle on my current fatty state. I didn't even have my calories low enough for it to make sense when I first started. My first cut cycle.

Dude you went from 340 from drinking slushy and Mountain Dew to 305 and you are saying you’re a beast not obese? Please post some pics and let’s us deside. You realize that’s just 35lb lost ? And you think you are a beast? Do you mean a bodybuilding beast or over weight beast? And I’m not joking. If your health markers are that bad it ain’t from bodybuilding beast. If you have no pics to post then you are trolling. Prove me wrong and I will openly apologize to you

 

[qbkilla]

you are still over 300#, obese. You don`t need tren, clen, winstrol! Geez F`ing A. TRT and train, eat right, be hungry once in a while. If you are doing those right, at your body fat, fat should come pouring off of you. Get that body fat to 15 % before touching that stuff and by then your liver enzymes should be better.

This imo is what you need to hear although you'd probably be prefer to jump on a supplement or drug. Get to 12 percent, lose weight, get lean, diet and cardio are the best thing you could do for your liver. The basics...the foundation...not the cherry on top.

 

[neutrino]

Have a bowl of popcorn on standby. Waiting for pics

Dude you went from 340 from drinking slushy and Mountain Dew to 305 and you are saying you’re a beast not obese? Please post some pics and let’s us deside. You realize that’s just 35lb lost ? And you think you are a beast? Do you mean a bodybuilding beast or over weight beast? And I’m not joking. If your health markers are that bad it ain’t from bodybuilding beast. If you have no pics to post then you are trolling. Prove me wrong and I will openly apologize to yo

 

[b-boy]

Stop feeding the trolls

 

[Damaged1]

Just get it over with and post pics..you may get a few negative posts because of the way you came on strong here but the vast majority of the dudes i have chatted with on these forums will give you constructive criticism, honest opinions, and will generally give strong advice and plans on how to achieve your goals. Start honest and people here will go above and beyond to help you. This is an amazing community here.