GH causes hyperglycemia. I pulled this off a quick search to back up the GH/hyperglycemia comment. In American GH product inserts it is common to see the reference to hyperglycemia and dibaetes warnings below in bold and underlined.
"In their article on drug-induced hyperglycemia, Drs Luna and Feinglos1 did not discuss growth hormone (GH), which is known to induce hyperglycemia.2-3 The approved indications for GH have expanded substantially in the United States in the last several years. For growth-enhancing purposes, GH indications now include short stature associated with small gestational age and Prader Willi and Turner syndromes.4 In addition, GH has also been approved for the treatment of cachexia associated with acquired immunodeficiency syndrome (AIDS).4 For all of these conditions, and particularly AIDS-associated cachexia, dosages are in excess of those previously indicated for replacement therapy in children with GH deficiency. Higher dosages of GH are also approved for the treatment of GH deficiency in adolescents, and GH has also been approved as replacement therapy for adults with GH deficiency.4 The recommended doses for adults, however, are substantially smaller than for children.
Despite the small GH dosages used to treat GH deficiency in adults, such patients are likely to experience hyperglycemia more commonly than children treated for GH deficiency because adults are more likely to be overweight, which increases insulin resistance. Similar alterations in glucose homeostasis are also found more frequently in children with small gestational age and Prader Willi and Turner syndromes, which are associated with some degree of insulin resistance.5 Moreover, the pharmacological dosages of GH that are used to treat AIDS-associated cachexia have led to a recent change in the label, which states that "cases of new onset glucose intolerance, diabetes mellitus and exacerbation of preexisting diabetes mellitus" as well as "the development of diabetes ketoacidosis and coma" have been reported with the use of GH. In some of these patients the glucose intolerance persisted despite GH discontinuation.4
Finally, there are several off-label uses of GH. These include cosmetic or rejuvenating purposes, chiefly in the elderly; muscle-enhancement in athletes; and the improvement of lipodystrophy in patients with AIDS. Hence, all these populations may also experience GH-induced hyperglycemia, particularly those patients who have AIDS-related lipodystrophy and are receiving protease inhibitors. The benefit of GH use for all these purposes is questionable, and the long-term risks remain unknown.5
Saul Molazowski, MD,PhD,MBA
National Institute of Diabetes and Digestive and Kidney Diseases
Bethesda, Md
1. Luna B, Feinglos MA. Drug-induced hyperglycemia. JAMA. 2001;286:1945-1948. FREE FULL TEXT
2. Williams RH, Foster DW, Kronenberg HM, Larsen PR. Williams Textbook of Endocrinology. 9th ed. St Louis, Mo: WB Saunders Co; 1998.
3. Chan JC, Cockram CS, Critchley JA. Drug induced disorders of glucose metabolism: mechanisms and management. Drug Saf. 1996;15:135-157. ISI | PUBMED
4. Medical Economics Co. Physician's Desk Reference. Montvale, NJ: Medical Economics Co; 2001.
5. Critical evaluation of the safety of recombinant human growth hormone administration: statement from the Growth Hormone Research Society. J Clin Endocrinol Metab. 2001;86:1868-1870. FREE FULL TEXT
This was the entire article.
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GH also affects T3 conversion from T4 as well as AAS affect the thyroid also.
BB'ers are so diverse with their doses and cycling patterns and choices it's hard to find data on this although Avant labs (nandi-RIP) wrote a good article on AAS and the thyroid.
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some additional stuff from a random source:
Steroid use decreases the glucose tolerance, while there is an increase in insulin resistance. These changes mimic Type II diabetes. These changes seem to be reversible after abstention from the drugs.
AS use may affect thyroid function. Administration of AS has been found to decrease thyroid stimulation hormone (TSH), and the products of the thyroid gland. In addition, thyroid binding globulin (TBG). These changes reversed within weeks after discontinuation of AS use.
I won't advise people one what to do but used to check my blood glucose and Thyroid profiles when on those things, and still do when off.
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