Cutting question - should I use DNP?

[Mufasa123]

I don't know if slin and dnp are that comparable? Sure, both 1 fuckup and your dead. But id assume even if someone doesn't od on dnp, it's far from harmless considering how it makes people feel and the sides. Id actually be interested to see if anyone has gotten blood work pre and during a dnp run. I remember there was also something years ago called usnic acid or something?

I've had bloods done on and post DNP. Multiple occasions. Others here have as well. No elevation or issues on CBC, CMP, I think insulin sensativty/glucose improved marginally. Nothing negative - not just "in range" but in range and in relation to my own norms. A few small improvements were likely noise or just not significant but nothing was elevated, got worse, or skewed negative.

DNP basicslly does one thing and only one thing which is kind of ideal. Do too much of that thing and it starts at related side effects and moves to real temp issues if the body can't regulate itself against an overwhelmingly reckless dosage. Longer half life so it builds and doesn't come out quickly - no way to stop it so you have to ride it out. This is where people get into trouble.

Lots of studies in the 1930s and covered maybe 100k humans in the US at the time. Tiny fraction (like 7 from memory and all women, got cataracts on long runs), you can get some nerve issues (very rare but stop immediately), and a few people died but that's an issue of humans being dumb, taking way too much and self control. OD is not common even in a community like BBing which tends to get risky or excessive types - you have to be really careless. But, it's gotten a few. Boggles my mind how people did this to themselves but welcome to humans.

Most guys here that use or have used it, favor a low dose for longer. This is how it was used in the 30s by doctors. Very low incidence of sides. All the major sides/felt like death/laid in bed for days with fans on me/etc reported are people running short super high dose inferno cycles that were popular 10+ years ago - dumb and yet even those nimrods survived (I did mention BBing community can skew excessive right).

 

[bigbumpkin2003]

I would think Boston was multiple issues caused his death. If he ran half of what he said he was even that would be excessive by most standards.

The DNP it’s like everything else… your life your choice. For sure be educated before making a decision. Me personally, I am older and my life is limited at this point. I have waaayy too many amazing things going on in my life to gamble with it in any way. I personally won’t do anything to jeopardize my health now that I have a great woman by my side. I am looking to add years to my life in any way possible… not take them away.


Do what you will but please do it in the safest manner possible if so chose

 

[qbkilla]

I would think Boston was multiple issues caused his death. If he ran half of what he said he was even that would be excessive by most standards.

The DNP it’s like everything else… your life your choice. For sure be educated before making a decision. Me personally, I am older and my life is limited at this point. I have waaayy too many amazing things going on in my life to gamble with it in any way. I personally won’t do anything to jeopardize my health now that I have a great woman by my side. I am looking to add years to my life in any way possible… not take them away.


Do what you will but please do it in the safest manner possible if so chose

I still cant believe how many people thought that kid was a positive influence ... "he's so honest and open abouthis dosages...its refreshing." A positive influence doesn't commit suicide by gear/drug abuse..its kids like him why aas use is stigmatized and illegal. And the fact he was scamming and snitching when he wasn't crying for attention.

 

[specter]

I've had bloods done on and post DNP. Multiple occasions. Others here have as well. No elevation or issues on CBC, CMP, I think insulin sensativty/glucose improved marginally. Nothing negative - not just "in range" but in range and in relation to my own norms. A few small improvements were likely noise or just not significant but nothing was elevated, got worse, or skewed negative.

DNP basicslly does one thing and only one thing which is kind of ideal. Do too much of that thing and it starts at related side effects and moves to real temp issues if the body can't regulate itself against an overwhelmingly reckless dosage. Longer half life so it builds and doesn't come out quickly - no way to stop it so you have to ride it out. This is where people get into trouble.

Lots of studies in the 1930s and covered maybe 100k humans in the US at the time. Tiny fraction (like 7 from memory and all women, got cataracts on long runs), you can get some nerve issues (very rare but stop immediately), and a few people died but that's an issue of humans being dumb, taking way too much and self control. OD is not common even in a community like BBing which tends to get risky or excessive types - you have to be really careless. But, it's gotten a few. Boggles my mind how people did this to themselves but welcome to humans.

Most guys here that use or have used it, favor a low dose for longer. This is how it was used in the 30s by doctors. Very low incidence of sides. All the major sides/felt like death/laid in bed for days with fans on me/etc reported are people running short super high dose inferno cycles that were popular 10+ years ago - dumb and yet even those nimrods survived (I did mention BBing community can skew excessive right).

You do dont think those studies could be flawed or biased ? personally i wouldnt hang my hat to hard on studies done pre the aged the medical community acknowledge that anabolic steroids build muscle..

 

[Mufasa123]

You do dont think those studies could be flawed or biased ? personally i wouldnt hang my hat to hard on studies done pre the aged the medical community acknowledge that anabolic steroids build muscle..

They seem pretty good and really big samples with lots of real world people (100k plus and multiple countries/continents) being prescribed too over years (so in field, on humans, and active which is where you tend to find things that slip through fda testing). Plus it's more reporting on findings and no real ax to grind or skew to try to prove. Kind of as good a case as it gets and no one has taken issue with them back then or more recently.

Issue is handing a super emotional addictive (to food) personality a 30 day supply, they start binging out on food and just up the dose to counter it hitting the 1-2gram level, at first OK and then building into danger zone. Bodybuilders seem to combine with diuretics to combat DNP bloat which is hugely problematic as the water retention DNP causes is the body regulating temp from increased metabolism so this directly interferes with main coping method.

On the AAS it's more a public knowledge vs real industry action. I remember back in the 90s when PDR was still saying they don't build muscle or enhance performance unless someone was deficient. That was all political. We were using testosterone on muscle wasting back in the 40s and seeing what it would do. It was being used in Olympics in the 50s by us and the Russians, and Ciba plus others were trying to enhance the "goods" or anabolic effects vs sides quickly. Dianabol was the first released in 1958 and Zeigler (the creator at Ciba) was at York Barbell immediately so intent/purpose/use was evident. Evidence clearly is real medical community, drug companies/government and serious docs in field, were on it fast. Official "word" and general public and practitioner knowledge was just suppressed but real medical community very obviously knew and believed strongly enough that we've seen the large investment in developing plethora of derivative drugs we still have today.

 

[Tomgrass]

Eca , yohimbine , frag , hgh , otc fatburners etc and you decided fuck it i will go for dnp…. This is literally you are asking : i am gonna start my first cycle - do you think gram of tren is enough?

 

[Sectør]

Has anyone had their hs-CRP (inflammation markers) taken while on DNP?

Seen it commonly referenced that DNP can increase hs-CRP 2-5x baseline with the stress it puts on the body.

On another forum there was a guy that tiltrated up to 600mg/day for 8 days then posted bloodwork with an hs-CRP of 111 (max of the reference range was was 5)—so 22x the maximum reference range. Obviously there was probably other factors that contributed to his values, but it has me curious how much inflammation others have seen/noted with it

 

[Mufasa123]

Has anyone had their hs-CRP (inflammation markers) taken while on DNP?

Seen it commonly referenced that DNP can increase hs-CRP 2-5x baseline with the stress it puts on the body.

On another forum there was a guy that tiltrated up to 600mg/day for 8 days then posted bloodwork with an hs-CRP of 111 (max of the reference range was was 5)—so 22x the maximum reference range. Obviously there was probably other factors that contributed to his values, but it has me curious how much inflammation others have seen/noted with it

I have not and haven't spoken to or seen anyone that has. I can offer this which is a bit odd but makes me think just pure metabolic stress it is likely increasing and if paired with other things... at least additive. That said 600mg is a big dose. When it was used medically doses were 100-200 range for most all. 600 ED is major sides for nearly everyone and debilitating to life for a lot of us. I max at 250/500 alternating. I've run 500ed as an experiment and won't bother again.

You've probably read enough of my posts to know that I'm prone to inflammation and specifically carb/diet driven (blood pressure increases, muscle knots, familial tremors in hands increase significantly). Point being, I'm very familiar with symptoms in my body.

On all my DNP runs it may increase but I notice at most a slight increase in symptoms - maybe just my imagination too. That said, last run I started right on the back of a 4 week tren ace stint at 350mg. Tren is itself inflammatory to me and others I'd think. Symptoms of inflammation and just general sides showed up fast and were greatly elevated vs comparable dosing before - then again so were results on this run (note all my DNP has been same batch). Tren was stopping so definitely DNP as catalyst but much worse than other runs (better results too). Thinking tren was gradually coming out and there's an almost synergistic effect - good and bad. This was only one run but different than all others and definitely pointed to inflammation in body (much greater than tren or DNP by themselves).

Wish I had 4-5 blood tests for you but that experience made me conclude yes to inflammation and to be careful what I'm running it with. DNP is fucking with body at a cellular level, that's a lot of strain as indicated logically by massive increase in resting BMR and it making you tired/lethargic at higher doses/bmrs.

 

[specter]

They seem pretty good and really big samples with lots of real world people (100k plus and multiple countries/continents) being prescribed too over years (so in field, on humans, and active which is where you tend to find things that slip through fda testing). Plus it's more reporting on findings and no real ax to grind or skew to try to prove. Kind of as good a case as it gets and no one has taken issue with them back then or more recently.

Issue is handing a super emotional addictive (to food) personality a 30 day supply, they start binging out on food and just up the dose to counter it hitting the 1-2gram level, at first OK and then building into danger zone. Bodybuilders seem to combine with diuretics to combat DNP bloat which is hugely problematic as the water retention DNP causes is the body regulating temp from increased metabolism so this directly interferes with main coping method.

On the AAS it's more a public knowledge vs real industry action. I remember back in the 90s when PDR was still saying they don't build muscle or enhance performance unless someone was deficient. That was all political. We were using testosterone on muscle wasting back in the 40s and seeing what it would do. It was being used in Olympics in the 50s by us and the Russians, and Ciba plus others were trying to enhance the "goods" or anabolic effects vs sides quickly. Dianabol was the first released in 1958 and Zeigler (the creator at Ciba) was at York Barbell immediately so intent/purpose/use was evident. Evidence clearly is real medical community, drug companies/government and serious docs in field, were on it fast. Official "word" and general public and practitioner knowledge was just suppressed but real medical community very obviously knew and believed strongly enough that we've seen the large investment in developing plethora of derivative drugs we still have today.

Can you link me these studies ?
I know the history of aas, it was more to give a point that sometimes things get fucked even though we have proof or otherwise. Hitting 2grams of DNP is pure madness !

 

[Mufasa123]

Apparently terminal starts at 1gram (very low end of spectrum and needs tk be sustained for days - won't be terminal for more than a small minority). Most are close to 2 grams sustained or above. Most of the people who use dnp on this site use 100-250 where even sides are low. I max at 250/500 alternating. Debilitating sides for most are 500-750 Ed. Just sucks. Knowing the mechanism and risk, seeing how you feel on doses in this range- someone needs to be a total moron to get to terminal doses. Strong diuretic use concurrently with high dose dnp is also dumb as hell as this short circuits the body's main temperature regulating mechanism.

There is a big older thread here with both links and quoted pieces which actually matter. I forget the users name (he didn't start it) but like the 1 of 2 repositories that are easily navigable. The other I think is on meso maybe sticked or not but in the diet drug sub forum. I searched and the one here didn't come up quickly which is odd. Conciliator was the main person posting. Probably search him with dnp 2007-2012 era.

ML Tainter from memory was the major US researcher in 1930s that turned out a ton. He has one specifically on toxicity/poisoning but most is use/effect/treatment. I'd start with him and anyone he quoted or who quoted him. Tons of other studies on it but he did the big ones from memory. A lot is hard to get access too if you don't have subscriptions/academic access. Shit is old.

https://jamanetwork.com/journals/jama/article-abstract/245872

https://www.semanticscholar.org/paper/USE-OF-DINITROPHENOL-IN-OBESITY-AND-RELATED-A-Tainter-Stockton/87e36f7b11c54454ee4f7a2d1a253d85994ba7ff

I just out this in ChatGPT so likely good to check out too but I'd find those threads. The main contributors to them are super knowledgeable and reference/cite/link studies for you. Thats where I started and expanded from.

"Can you please find me names and possibly links where available on the major pre 1950s research into human use of 2,4-dinitrophenol in treating obesity in humans. One of the main researchers' last names was Tainter if that helps."