You will likely feel better, maintain more stable hormone levels, and reduce potential side effects by splitting up the dosages (twice per week, every other day, or three times per week) and refraining from once weekly administration.
What is your intended duration for these compounds?
What is your purpose of including Metformin? This can be a very good addition for most. Be sure to look into some of the common micro-nutrient (think B-vitamins), CoQ10, and electrolyte deficiencies that can result when used; very easy to manage, however, just a note to always look into all aspects of anything you are including, despite the benefits.
Intended strength of Nolvadex and Anastrozole? Any history of high aromatization or current or prior gynecomastia?
Whenever using orals, actually this applies to everything, but you better have a damn good reason. So keep that in mind. How do you plan on dosing the 40 mg (all at once, every 4-6 hours, etc?) Any TUDCA, Liv-52?