- Joined
- Aug 30, 2011
- Messages
- 20
Years back got a mild case of shingles at age 27! (My overall heath and fitness was very good at the time). Dr gave me a Rx and luckily it cleared up quickly. I did some searching on the on the web and found a link between Arginine and suppressed immune function leading to shingles.
I was wondering if anyone else has had similar effects seeing that I want to try supplementing with NO in the future. From what I understand it's does dependent and supplementing with Lysine counteracts the negative effects.
here's some quick info I found:
http://www.ncbi.nlm.nih.gov/pubmed/12234710
Expression of inducible nitric oxide synthase in skin lesions of acute herpes zoster.
Abstract
Histopathologically, the skin lesions of acute herpes zoster (AHZ) are characterized by epidermal necrotic vesicles with inflammation. Nitric oxide (NO) is generated from L-arginine by nitric oxide synthase (NOS), and immune inflammation involves the activation of NOS in both effector cells and target cells. NO can cause apoptosis and necrosis of target cells such as keratinocytes. We proposed that a large burst of NO in AHZ may cause the epidermal necrosis. Skin biopsies were taken from 13 patients with AHZ. The expression of inducible-type NOS (iNOS) was examined by immunoperoxidase staining and reverse transcription-polymerase chain reaction (RT-PCR). In the skin specimen of AHZ, moderate-to-strong staining for iNOS was observed in inflammatory cells and necrotic keratinocytes, while weak staining was observed in non-necrotic peripheral keratinocytes. RT-PCR using skin specimen of AHZ corroborated the immunoperoxidase findings, yielding bright bands for iNOS. Normal control skin showed minimal or negative expression both by immunoperoxidase stains and RT-PCR. Increased expression of iNOS is consistent with the hypothesis that high level of NO induced by iNOS may be associated with the epidermal necrosis with inflammation seen in the skin lesions of AHZ.
and
http://www.livestrong.com/article/282526-arginine-and-shingles/
"Risks
The major risk of avoiding high arginine foods during a shingles outbreak is that it will have no effect. There is no direct evidence linking arginine consumption to the risk of developing shingles, nor is there any direct evidence that arginine consumption influences the duration or severity of symptoms, once the disease occurs. The evidence linking arginine to herpes simplex is direct, but weak. In the 2007 edition of "Integrative Medicine," University of Wisconsin professor David Rakel, M.D. says that clinical studies have shown mixed results.
Benefits
Limiting arginine consumption during a shingles outbreak could modestly improve the duration or severity of symptoms. For example, in the case of herpes simplex, a 1987 study published in the journal "Dermatologica" and led by Indiana University professor of infectious diseases Richard Griffith found that 74 percent of people who took lysine, an amino acid that counteracts the effects of arginine, rated it as "effective" or "very effective" at controlling symptoms."
and
http://shinglesdiseaseguide.com/
"The amino acid lysine inhibits herpes activity and can help shorten an attack. You only need to take lysine supplements during the course an outbreak. In addition, avoid arginine-rich foods such as chocolate, peanuts, seeds, and cereal grains. Arginine is another amino acid, but its effect on the virus is the opposite of lysine’s: It promotes herpes growth."
I was wondering if anyone else has had similar effects seeing that I want to try supplementing with NO in the future. From what I understand it's does dependent and supplementing with Lysine counteracts the negative effects.
here's some quick info I found:
http://www.ncbi.nlm.nih.gov/pubmed/12234710
Expression of inducible nitric oxide synthase in skin lesions of acute herpes zoster.
Abstract
Histopathologically, the skin lesions of acute herpes zoster (AHZ) are characterized by epidermal necrotic vesicles with inflammation. Nitric oxide (NO) is generated from L-arginine by nitric oxide synthase (NOS), and immune inflammation involves the activation of NOS in both effector cells and target cells. NO can cause apoptosis and necrosis of target cells such as keratinocytes. We proposed that a large burst of NO in AHZ may cause the epidermal necrosis. Skin biopsies were taken from 13 patients with AHZ. The expression of inducible-type NOS (iNOS) was examined by immunoperoxidase staining and reverse transcription-polymerase chain reaction (RT-PCR). In the skin specimen of AHZ, moderate-to-strong staining for iNOS was observed in inflammatory cells and necrotic keratinocytes, while weak staining was observed in non-necrotic peripheral keratinocytes. RT-PCR using skin specimen of AHZ corroborated the immunoperoxidase findings, yielding bright bands for iNOS. Normal control skin showed minimal or negative expression both by immunoperoxidase stains and RT-PCR. Increased expression of iNOS is consistent with the hypothesis that high level of NO induced by iNOS may be associated with the epidermal necrosis with inflammation seen in the skin lesions of AHZ.
and
http://www.livestrong.com/article/282526-arginine-and-shingles/
"Risks
The major risk of avoiding high arginine foods during a shingles outbreak is that it will have no effect. There is no direct evidence linking arginine consumption to the risk of developing shingles, nor is there any direct evidence that arginine consumption influences the duration or severity of symptoms, once the disease occurs. The evidence linking arginine to herpes simplex is direct, but weak. In the 2007 edition of "Integrative Medicine," University of Wisconsin professor David Rakel, M.D. says that clinical studies have shown mixed results.
Benefits
Limiting arginine consumption during a shingles outbreak could modestly improve the duration or severity of symptoms. For example, in the case of herpes simplex, a 1987 study published in the journal "Dermatologica" and led by Indiana University professor of infectious diseases Richard Griffith found that 74 percent of people who took lysine, an amino acid that counteracts the effects of arginine, rated it as "effective" or "very effective" at controlling symptoms."
and
http://shinglesdiseaseguide.com/
"The amino acid lysine inhibits herpes activity and can help shorten an attack. You only need to take lysine supplements during the course an outbreak. In addition, avoid arginine-rich foods such as chocolate, peanuts, seeds, and cereal grains. Arginine is another amino acid, but its effect on the virus is the opposite of lysine’s: It promotes herpes growth."