dbol affects on free & total testosterone?

[WeirdAl]

Anyone know what if any affects dbol has on free and total testosterone readings? EQ also, for that matter...

 

[xcelbeyond]

I don't really know but I would assume they would raise it noticeably.

xcel

 

[MikeS]

It will effect it in 2 ways. By its Receptor Binding Affinity to the SBGH, which control the ratio of free vs bound test. And second by the reduction of amount of circulating test, free or bound, caused by HPTA shutdown. I looked up some AS for their specific
SBGH affinity, and dbol or EQ werent mentioned. Meaning they do not especially differ from your typical AS, as those that had a high binding affinity were spelled out (Proviron/DHT...).

 

[einstein1905]

Androgens decrease SHBG levels, whereas estrogens raise SHBG levels. However, some androgens aromatize to estrogens. It turns out that as you increase the androgen levels, aromatase activity is a limiting factor and does not cause a proportionate rise in estrogens, and therefore SHBG levels, so you'll have a higher % of bioavailable test because of two factors: 1) higher androgen:estrogen ratio and 2) lower SHBG:androgen (AAS) ratio.

Also, on a tangent, tren has a particularly low affinity for SHBG.

Here's a good relevant study:

"Peak concentrations of total T increased by 5-fold, but free and non-SHBG-bound T levels were increased by 10-fold after 16 weeks."

Clin Endocrinol Metab 1996 Mar;81(3):896-901

Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study. II. Pharmacokinetics and pharmacodynamics of once weekly administration of testosterone enanthate.

Anderson RA, Wu FC.

 

[WeirdAl]

does this mean any exogenous "supplementation" will raise your free test levels?

 

[WeirdAl]

and if one were supplementing, and about to get a free test level checked, any way to lower that? Give blood? Something else? Just curious, I know there are several people here on hrt

 

[einstein1905]

Exogenous "supplementation" of androgens will lower SHBG, so raise free test. Donating blood won't lower the % of free test, it will only lower the value of the number (ng/dL), but your bound test levels will drop accordingly too, keeping the free test % constant. Cheating HRT tests is tough. If you use prop, you can time things right so as to lower total test to a reasonable level at test time, which will also allow free test to drop some in the process. Most on HRT only get tested every 2-3 months, so you can time things with prop so as not to be really inconvenienced, if remaining on HRT is important.